Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CASP3_HUMAN
Description:caspase 3, apoptosis-related cysteine peptidase [Source:HGNC Symbol;Acc:1504]
Location:chr4 q35.1
Node attribute:PPI(target); cleavage(source); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S150GDRCRsLTGKPPeptidase_C14PhosphoSitePlus
S150GDRCRsLTGKPp38a(MAPK14RegPhos
S26IHGSEsMDSGIHPRD; RegPhos
S24KIIHGsESMDSPhosphoSitePlus
S150GDRCRsLTGKPMAPK14phosphoELM
Y41SYKMDyPEMGLPhosphoSitePlus
T67TSRSGtDVDAAPeptidase_C14PhosphoSitePlus
S12SVDSKsIKNLEPhosphoSitePlus
S10ENSVDsKSIKNPhosphoSitePlus
S65GMTSRsGTDVDPeptidase_C14PhosphoSitePlus
T270IVSMLtKELYFHPRD
S7ENTENsVDSKSPhosphoSitePlus
T4__MENtENSVDPhosphoSitePlus

Dephosphorylation site
CASP3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000311032G129*COSMICSkin Cancer21984974
ENSP00000428929G129*COSMICSkin Cancer21984974

Differential expressed protein
CASP3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CASP3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK14_HUMANCASP3_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANCASP3_HUMANkinase -> substrateRegPhos
CASP3_HUMANAKT1_HUMANcleavageNetPath
CASP3_HUMANIKKB_HUMANotherNetPath
CASP3_HUMANANDR_HUMANotherNetPath
CASP3_HUMANDCC_HUMANotherKEGG
CASP3_HUMANSTK3_HUMANotherKEGG
TNR1A_HUMANCASP3_HUMANotherKEGG
CASP8_HUMANCASP3_HUMANotherKEGG
CASP3_HUMANM3K1_HUMANotherKEGG
IL1R1_HUMANCASP3_HUMANotherKEGG
CASP9_HUMANCASP3_HUMANotherKEGG
CASP3_HUMANPKN1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05146Amoebiasis
hsa05152Tuberculosis
hsa05010Alzheimer's disease
hsa04115p53 signaling pathway
hsa05134Legionellosis
hsa04210Apoptosis
hsa05145Toxoplasmosis
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04726Serotonergic synapse
hsa04650Natural killer cell mediated cytotoxicity
hsa05203Viral carcinogenesis
hsa05210Colorectal cancer
hsa04010MAPK signaling pathway
hsa05168Herpes simplex infection
hsa05200Pathways in cancer
hsa05012Parkinson's disease
hsa05016Huntington's disease
hsa05416Viral myocarditis
hsa05133Pertussis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008625extrinsic apoptotic signaling pathway via death doIEAbiological_process
GO:0043066negative regulation of apoptotic processIGIbiological_process
GO:0001836release of cytochrome c from mitochondriaIEAbiological_process
GO:0046007negative regulation of activated T cell proliferatIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0030216keratinocyte differentiationIEAbiological_process
GO:0030264nuclear fragmentation involved in apoptotic nucleaIMPbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0007605sensory perception of soundIEAbiological_process
GO:0035329hippo signaling cascadeTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0045736negative regulation of cyclin-dependent protein kiIEAbiological_process
GO:0043029T cell homeostasisIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0005829cytosolIDAcellular_component
GO:0042981regulation of apoptotic processTASbiological_process
GO:0051402neuron apoptotic processIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0045786negative regulation of cell cycleIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0001782B cell homeostasisIEAbiological_process
GO:0004190aspartic-type endopeptidase activityIEAmolecular_function
GO:0045165cell fate commitmentIEAbiological_process
GO:0008233peptidase activityIDAmolecular_function
GO:0008631intrinsic apoptotic signaling pathway in response IEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0008635activation of cysteine-type endopeptidase activityTASbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:0008233peptidase activityIEAmolecular_function
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0006508proteolysisIEAbiological_process
GO:0030889negative regulation of B cell proliferationIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0005739mitochondrionIDAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0034612response to tumor necrosis factorTASbiological_process
GO:0004197cysteine-type endopeptidase activityIEAmolecular_function
GO:0071310cellular response to organic substanceIEAbiological_process
GO:0009611response to woundingIEAbiological_process
GO:0008234cysteine-type peptidase activityIEAmolecular_function
GO:0016485protein processingIEAbiological_process
GO:0004861cyclin-dependent protein kinase inhibitor activityIEAmolecular_function
GO:0006309apoptotic DNA fragmentationIEAbiological_process
GO:0009411response to UVIEAbiological_process
GO:0097190apoptotic signaling pathwayTASbiological_process


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