Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DAXX_HUMAN
Description:death-domain associated protein [Source:HGNC Symbol;Acc:2681]
Location:chrHSCHR6_MHC_MCF p2
Node attribute:PPI(source); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y379EVISKyAMLQDDaxxPhosphoSitePlus
S515PGKQIsRSSGEDaxxPhosphoSitePlus
S498DKSPMsSLQISHPRD
S690RVDSPsHGLVTHPRD; phosphoELM
S682APVADsSTRVDHPRD
S213KELDLsELDDPHPRD; phosphoELM
T249DCSSLtGRVIEDaxxPhosphoSitePlus
S737EIIVLsDHPRD; phosphoELM
S176AENTAsQSPRTDaxxPhosphoSitePlus
S707SPARLsQTPHSDaxxPhosphoSitePlus
S712SQTPHsQPPRPDaxxPhosphoSitePlus
S697GLVTSsLCIPSHPRD
T665GKKICtLPSPPHPRD
S702SLCIPsPARLSDaxxPhosphoSitePlus
S424PSGMAsQGCPSHPRD
S176AENTAsQSPRTHPRD; phosphoELM
T169LSLDPtNAENTHPRD; phosphoELM
Y124RPAKLyVYINEDaxxPhosphoSitePlus
S415EASLDsGEGPSDaxxPhosphoSitePlus
S498DKSPMsSLQISDaxxPhosphoSitePlus
S739IVLSDHPRD; phosphoELM
S690RVDSPsHGLVTDaxxPhosphoSitePlus
S739IVLSDsD____DaxxPhosphoSitePlus
S420SGEGPsGMASQDaxxPhosphoSitePlus
S688STRVDsPSHGLDaxxPhosphoSitePlus
S654VERQRsVHEKNDaxxPhosphoSitePlus
S495KDGDKsPMSSLDaxxPhosphoSitePlus; SysPTM
T709ARLSQtPHSQPDaxxPhosphoSitePlus
S97QQRAHsLFLASHPRD
S671LPSPPsPLASLHPRD; phosphoELM; SysPTM
Y379EVISKyAMLQDHPRD
T174TNAENtASQSPHPRD; phosphoELM
S495KDGDKsPMSSLHPRD; phosphoELM; SysPTM
Y334HLDLIyNFGCHDaxxPhosphoSitePlus
Y344HLTDDyRPGVDDaxxPhosphoSitePlus
T408SHSADtPEASLDaxxPhosphoSitePlus
S184PRTRGsRRQIQDaxxPhosphoSitePlus
S246ELKDCsSLTGRDaxxPhosphoSitePlus
T695SHGLVtSSLCIDaxxPhosphoSitePlus
Y648PLGNSyVERQRHPRD; phosphoELM; SysPTM
S499KSPMSsLQISNHPRD
S675PSPLAsLAPVAHPRD
S688STRVDsPSHGLHPRD; phosphoELM
S178NTASQsPRTRGHPRD; phosphoELM
Y126AKLYVyINELCDaxxPhosphoSitePlus
S671LPSPPsPLASLDaxxPhosphoSitePlus; SysPTM
S515PGKQIsRSSGEHPRD
S412DTPEAsLDSGEDaxxPhosphoSitePlus
S178NTASQsPRTRGDaxxPhosphoSitePlus
S675PSPLAsLAPVADaxxPhosphoSitePlus
Y648PLGNSyVERQRDaxxPhosphoSitePlus; SysPTM
S702SLCIPsPARLSHPRD; phosphoELM
T709ARLSQtPHSQPHPRD; phosphoELM
S712SQTPHsQPPRPHPRD; phosphoELM
T665GKKICtLPSPPDaxxPhosphoSitePlus
S668ICTLPsPPSPLDaxxPhosphoSitePlus
S424PSGMAsQGCPSDaxxPhosphoSitePlus
S737EIIVLsDSD__DaxxPhosphoSitePlus
S213KELDLsELDDPDaxxPhosphoSitePlus
S668ICTLPsPPSPLHPRD; phosphoELM

Dephosphorylation site
DAXX_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000266000S534*COSMICOvarian Cancer21720365
ENSP00000363668A297PCOSMICPancreatic Cancer21252315
ENSP00000363668E448*COSMICPancreatic Cancer21252315
ENSP00000266000S588FCOSMICSkin Cancer21984974
ENSP00000266000R306*COSMICPancreatic Cancer21252315
ENSP00000363668S534*COSMICOvarian Cancer21720365
ENSP00000266000R203QCOSMICProstate Cancer20668451
ENSP00000363668K56*COSMICPancreatic Cancer21252315
ENSP00000266000A297PCOSMICPancreatic Cancer21252315
ENSP00000266000L130RCOSMICPancreatic Cancer21252315
ENSP00000363668E465*COSMICPancreatic Cancer21252315
ENSP00000266000S712*COSMICHead and Neck Cancer21798893
ENSP00000363668R306*COSMICPancreatic Cancer21252315
ENSP00000363668S712*COSMICHead and Neck Cancer21798893
ENSP00000363668P537TCOSMICHead and Neck Cancer21798893
ENSP00000363668R203QCOSMICProstate Cancer20668451
ENSP00000363668S588FCOSMICSkin Cancer21984974
ENSP00000266000N153SCOSMICPancreatic Cancer
ENSP00000363668N153SCOSMICPancreatic Cancer
ENSP00000363668L130RCOSMICPancreatic Cancer21252315
ENSP00000266000E465*COSMICPancreatic Cancer21252315
ENSP00000266000Q92ECOSMICHead and Neck Cancer21984974
ENSP00000266000Q551*COSMICMelanoma
ENSP00000266000R48TCOSMICOvarian Cancer21720365
ENSP00000363668Q551*COSMICMelanoma
ENSP00000266000K56*COSMICPancreatic Cancer21252315
ENSP00000266000P537TCOSMICHead and Neck Cancer21798893
ENSP00000266000E448*COSMICPancreatic Cancer21252315
ENSP00000266000T151NBIOMARTBreast Cancer21930507, 21930502
ENSP00000363668Q92ECOSMICHead and Neck Cancer21984974
ENSP00000363668T151NBIOMARTBreast Cancer21930507, 21930502
ENSP00000363668R48TCOSMICOvarian Cancer21720365

Differential expressed protein
DAXX_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DAXX_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K7_HUMANDAXX_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANDAXX_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANDAXX_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANDAXX_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANDAXX_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANDAXX_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANDAXX_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANDAXX_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANDAXX_HUMANkinase -> substrateRobert H Newman (2013)
TGFR1_HUMANDAXX_HUMANotherKEGG
DAXX_HUMANM3K5_HUMANotherKEGG
TNR1A_HUMANDAXX_HUMANotherKEGG
TNR6_HUMANDAXX_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05168Herpes simplex infection
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019048virus-host interactionIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0006917induction of apoptosisISSbiological_process
GO:0031072heat shock protein bindingTASmolecular_function
GO:0002039p53 bindingIPImolecular_function
GO:0031396regulation of protein ubiquitinationIDAbiological_process
GO:0005057receptor signaling protein activityTASmolecular_function
GO:0006915apoptotic processTASbiological_process
GO:0050681androgen receptor bindingIPImolecular_function
GO:0019899enzyme bindingIPImolecular_function
GO:0007257activation of JUN kinase activityTASbiological_process
GO:0016605PML bodyIEAcellular_component
GO:0000775chromosome, centromeric regionIEAcellular_component
GO:0047485protein N-terminus bindingIPImolecular_function
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0000281cytokinesis after mitosisIEAbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0005829cytosolISScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000792heterochromatinIEAcellular_component
GO:0030521androgen receptor signaling pathwayIDAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0008134transcription factor bindingIDAmolecular_function
GO:0008625extrinsic apoptotic signaling pathway via death doTASbiological_process
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0005730nucleolusIEAcellular_component