Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IF4H_HUMAN
Description:eukaryotic translation initiation factor 4H [Source:HGNC Symbol;Acc:12741]
Location:chrHG1257_PATCH q11.
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T201DFREPtEEERAPhosphoSitePlus
S230VANPNsAIFGGPhosphoSitePlus
Y101KEALTyDGALLHPRD; phosphoELM
Y45PPYTAyVGNLPRRM_1PhosphoSitePlus
S110LLGDRsLRVDIHPRD
S32GHGSRsQKELPPhosphoSitePlus
Y42PTEPPyTAYVGPhosphoSitePlus
T217QLKPRtVATPLPhosphoSitePlus
S13DDRAYsSFGGGHPRD; SysPTM
S173PPLRGsNMDFRHPRD
T220PRTVAtPLNQVPhosphoSitePlus
Y7ADFDTyDDRAYPhosphoSitePlus
Y86FKGFCyVEFDERRM_1PhosphoSitePlus
Y45PPYTAyVGNLPHPRD; phosphoELM
S14DRAYSsFGGGRPhosphoSitePlus; HPRD; SysPTM
Y12YDDRAySSFGGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S24RGSRGsAGGHGPhosphoSitePlus; HPRD
Y101KEALTyDGALLRRM_1PhosphoSitePlus
S110LLGDRsLRVDIRRM_1PhosphoSitePlus
S193PPLRGsNMDFRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S21GGGRGsRGSAGPhosphoSitePlus; HPRD
T43TEPPYtAYVGNPhosphoSitePlus

Dephosphorylation site
IF4H_HUMAN do not have dephosphorylation site.

Mutation site
IF4H_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000265753Lung CancerTreatment (none vs transfected with pc3.1-hPNAS5)cell lineDown19795389
ENSP00000265753Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.320804217
ENSP00000265753Uterine CancerTreatment(none vs. 5-Fluorouracil treatment)cell lineUp15585135

Hyperphosphorylation site
IF4H_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PKN1_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
STK24_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
GRK5_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
STK16_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
IF4H_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0003723RNA bindingTASmolecular_function
GO:0006446regulation of translational initiationTASbiological_process
GO:0008135translation factor activity, nucleic acid bindingTASmolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0003743translation initiation factor activityIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0000166nucleotide bindingIEAmolecular_function
GO:0006412translationTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0006413translational initiationTASbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0048589developmental growthIEAbiological_process
GO:0016281eukaryotic translation initiation factor 4F compleTAScellular_component
GO:0019953sexual reproductionIEAbiological_process


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