| UniProt/SwissProt ID: | WIPI3_HUMAN |
| Description: | WD repeat domain 45B [Source:HGNC Symbol;Acc:25072] |
| Location: | chr17 q25.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T100 | EIEFStEVKAV | PhosphoSitePlus | |
| Y65 | LFRCNyLALVG | PhosphoSitePlus | |
| Dephosphorylation site |
| WIPI3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000376139 | T161M | COSMIC | Central Nervous System Neoplasms | 21817013 | ENSP00000376139 | Q229E | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| WIPI3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| WIPI3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PKN1_HUMAN | WIPI3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MARK2_HUMAN | WIPI3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | WIPI3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PXK_HUMAN | WIPI3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| WIPI3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000045 | autophagic vacuole assembly | IBA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0032266 | phosphatidylinositol-3-phosphate binding | IBA | molecular_function |
| GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding | IBA | molecular_function |
| GO:0005737 | cytoplasm | IBA | cellular_component |