| UniProt/SwissProt ID: | PGAM1_HUMAN |
| Description: | phosphoglycerate mutase 1 (brain) [Source:HGNC Symbol;Acc:8888] |
| Location: | chr10 q24.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S31 | YDADLsPAGHE | HPRD | |
| S118 | KIWRRsYDVPP | His_Phos_1 | PhosphoSitePlus |
| Y119 | IWRRSyDVPPP | His_Phos_1 | PhosphoSitePlus |
| Y50 | LRDAGyEFDIC | His_Phos_1 | PhosphoSitePlus |
| S118 | KIWRRsYDVPP | PAK1 | phosphoELM; RegPhos |
| S31 | YDADLsPAGHE | His_Phos_1 | PhosphoSitePlus |
| S118 | KIWRRsYDVPP | HPRD; RegPhos | |
| Y26 | RFSGWyDADLS | His_Phos_1 | PhosphoSitePlus |
| Y26 | RFSGWyDADLS | HPRD; phosphoELM; RegPhos | |
| Y119 | IWRRSyDVPPP | HPRD | |
| S14 | IRHGEsAWNLE | HPRD; RegPhos; SysPTM | |
| S14 | IRHGEsAWNLE | His_Phos_1 | PhosphoSitePlus; SysPTM |
| Y133 | PDHPFySNISK | His_Phos_1 | PhosphoSitePlus |
| T146 | RYADLtEDQLP | HPRD | |
| S189 | AAHGNsLRGIV | His_Phos_1 | PhosphoSitePlus |
| S23 | LENRFsGWYDA | PAK1 | phosphoELM; RegPhos |
| Y133 | PDHPFySNISK | HPRD | |
| S23 | LENRFsGWYDA | His_Phos_1 | PhosphoSitePlus |
| T96 | HYGGLtGLNKA | His_Phos_1 | PhosphoSitePlus |
| S134 | DHPFYsNISKD | His_Phos_1 | PhosphoSitePlus |
| T238 | LGDEEtVRKAM | PhosphoSitePlus | |
| Y92 | LNERHyGGLTG | HPRD | |
| Y92 | LNERHyGGLTG | His_Phos_1 | PhosphoSitePlus |
| Dephosphorylation site |
| PGAM1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| PGAM1_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000359991 | Gastric Cancer | Metastasis | cell line | Down | 0.44 | 17022644 | ENSP00000359991 | colorectal cancer | Normal vs. Cancer | tissue | Up | 2.6 | 19098285 | ENSP00000359991 | Uterine Cancer | Normal vs. Cancer | tissue | Down | 17902640 | ENSP00000359991 | colorectal cancer | Metastasis | cell line | Up | 17503081 | ENSP00000359991 | Leukemia | Normal vs. Cancer | cell line | Up | 2 | 17022645 | ENSP00000359991 | Leukemia | Normal vs. Cancer | cell line | Up | 12 | 17022645 | ENSP00000359991 | Lung Cancer | Treatment (none vs. FK228 treatment) | cell line | Down | 18549279 | ENSP00000359991 | Oral Cancer | Normal vs. Cancer | tissue | Up | 2.5 | 19297561 | ENSP00000359991 | Breast Cancer | Normal vs. Cancer | tissue | Up | >10 | 15767701 | ENSP00000359991 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.31 | 16596714 | ENSP00000359991 | Melanoma | Treatment (none vs. metastasis suppressor 1 (BRMS1) overEXPressed) | cell line | Down | 0.72 | 17854218 | ENSP00000359991 | Melanoma | Treatment (none vs. metastasis suppressor 1 (BRMS1) silenced) | cell line | Up | 1.9 | 17854218 | ENSP00000359991 | hepatitis B virus | Normal vs. Cancer | cell line | Up | 16 | 19187611 | ENSP00000359991 | Neoplasms by Histologic Type | Cancer vs. Cancer | cell line | Up | 15750928 | ENSP00000359991 | Lung Cancer | Normal vs. Cancer | tissue | Up | 16342241 | ENSP00000359991 | Gastric Cancer | Treatment (none vs. Vincristine-resistant) | cell line | Up | 16525997 | ENSP00000359991 | Gastric Cancer | Metastasis | cell line | Down | 0.44 | 17022644 | ENSP00000359991 | Breast Cancer | Normal vs. Cancer | tissue | Up | 5.7 | 20005186 | ENSP00000359991 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.83 | 20052998 | ENSP00000359991 | Breast Cancer | Normal vs. Cancer | cell line | Up | 4.8 | 20052998 | ENSP00000359991 | Breast Cancer | Metastasis | cell line | Up | 5.9 | 20052998 | ENSP00000359991 | Breast Cancer | Normal vs. Cancer | tissue | Up | 1.7 | 20087651 | ENSP00000359991 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.3 | 20543960 | ENSP00000359991 | Breast Cancer | Normal vs. Cancer | tissue | Down | 20560667 | ENSP00000359991 | acute myeloid leukemia | Treatment (none vs. NSC606985 treatment) | cell line | Up | 4.6 | 17655343 | ENSP00000359991 | acute myeloid leukemia | Treatment (none vs. NSC606985 treatment) | cell line | Up | 2.3 | 17655343 | ENSP00000359991 | acute myeloid leukemia | Treatment (none vs. NSC606985 treatment) | cell line | Up | 17655343 | ENSP00000359991 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 3 hour) | cell line | Down | 0.3 | 15169874 | ENSP00000359991 | Renal Cancer | Normal vs. Cancer | tissue | Up | 1.7-4.2 | 12923786 | ENSP00000359991 | Uterine Cancer | Treatment (none vs. Suberonylanilide hydroxamic acid (SAHA) treatment) | cell line | Down | 0.2 | 19179759 | ENSP00000359991 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 4.1 | 19199705 |
| Hyperphosphorylation site |
| PGAM1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | PGAM1_HUMAN | kinase -> substrate | RegPhos |
| PKN1_HUMAN | PGAM1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00010 | Glycolysis / Gluconeogenesis |
| hsa01100 | Metabolic pathways |
| hsa00260 | Glycine, serine and threonine metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005829 | cytosol | IDA | cellular_component |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0045730 | respiratory burst | IDA | biological_process |
| GO:0016868 | intramolecular transferase activity, phosphotransf | IEA | molecular_function |
| GO:0005975 | carbohydrate metabolic process | TAS | biological_process |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0006110 | regulation of glycolysis | IDA | biological_process |
| GO:0004083 | bisphosphoglycerate 2-phosphatase activity | IEA | molecular_function |
| GO:0006096 | glycolysis | TAS | biological_process |
| GO:0004082 | bisphosphoglycerate mutase activity | IEA | molecular_function |
| GO:0004619 | phosphoglycerate mutase activity | IMP | molecular_function |
| GO:0006006 | glucose metabolic process | TAS | biological_process |
| GO:0043456 | regulation of pentose-phosphate shunt | IDA | biological_process |
| GO:0006094 | gluconeogenesis | TAS | biological_process |