Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PGAM1_HUMAN
Description:phosphoglycerate mutase 1 (brain) [Source:HGNC Symbol;Acc:8888]
Location:chr10 q24.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S31YDADLsPAGHEHPRD
S118KIWRRsYDVPPHis_Phos_1PhosphoSitePlus
Y119IWRRSyDVPPPHis_Phos_1PhosphoSitePlus
Y50LRDAGyEFDICHis_Phos_1PhosphoSitePlus
S118KIWRRsYDVPPPAK1phosphoELM; RegPhos
S31YDADLsPAGHEHis_Phos_1PhosphoSitePlus
S118KIWRRsYDVPPHPRD; RegPhos
Y26RFSGWyDADLSHis_Phos_1PhosphoSitePlus
Y26RFSGWyDADLSHPRD; phosphoELM; RegPhos
Y119IWRRSyDVPPPHPRD
S14IRHGEsAWNLEHPRD; RegPhos; SysPTM
S14IRHGEsAWNLEHis_Phos_1PhosphoSitePlus; SysPTM
Y133PDHPFySNISKHis_Phos_1PhosphoSitePlus
T146RYADLtEDQLPHPRD
S189AAHGNsLRGIVHis_Phos_1PhosphoSitePlus
S23LENRFsGWYDAPAK1phosphoELM; RegPhos
Y133PDHPFySNISKHPRD
S23LENRFsGWYDAHis_Phos_1PhosphoSitePlus
T96HYGGLtGLNKAHis_Phos_1PhosphoSitePlus
S134DHPFYsNISKDHis_Phos_1PhosphoSitePlus
T238LGDEEtVRKAMPhosphoSitePlus
Y92LNERHyGGLTGHPRD
Y92LNERHyGGLTGHis_Phos_1PhosphoSitePlus

Dephosphorylation site
PGAM1_HUMAN do not have dephosphorylation site.

Mutation site
PGAM1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000359991Gastric CancerMetastasiscell lineDown0.4417022644
ENSP00000359991colorectal cancerNormal vs. CancertissueUp2.619098285
ENSP00000359991Uterine CancerNormal vs. CancertissueDown17902640
ENSP00000359991colorectal cancerMetastasiscell lineUp17503081
ENSP00000359991LeukemiaNormal vs. Cancercell lineUp217022645
ENSP00000359991LeukemiaNormal vs. Cancercell lineUp1217022645
ENSP00000359991Lung CancerTreatment (none vs. FK228 treatment)cell lineDown18549279
ENSP00000359991Oral CancerNormal vs. CancertissueUp2.519297561
ENSP00000359991Breast CancerNormal vs. CancertissueUp>1015767701
ENSP00000359991Breast CancerNormal vs. Cancercell lineDown0.3116596714
ENSP00000359991MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) overEXPressed)cell lineDown0.7217854218
ENSP00000359991MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) silenced)cell lineUp1.917854218
ENSP00000359991hepatitis B virusNormal vs. Cancercell lineUp1619187611
ENSP00000359991Neoplasms by Histologic TypeCancer vs. Cancercell lineUp15750928
ENSP00000359991Lung CancerNormal vs. CancertissueUp16342241
ENSP00000359991Gastric CancerTreatment (none vs. Vincristine-resistant)cell lineUp16525997
ENSP00000359991Gastric CancerMetastasiscell lineDown0.4417022644
ENSP00000359991Breast CancerNormal vs. CancertissueUp5.720005186
ENSP00000359991Breast CancerNormal vs. Cancercell lineDown0.8320052998
ENSP00000359991Breast CancerNormal vs. Cancercell lineUp4.820052998
ENSP00000359991Breast CancerMetastasiscell lineUp5.920052998
ENSP00000359991Breast CancerNormal vs. CancertissueUp1.720087651
ENSP00000359991Breast CancerNormal vs. Cancercell lineUp1.320543960
ENSP00000359991Breast CancerNormal vs. CancertissueDown20560667
ENSP00000359991acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp4.617655343
ENSP00000359991acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp2.317655343
ENSP00000359991acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000359991Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.315169874
ENSP00000359991Renal CancerNormal vs. CancertissueUp1.7-4.212923786
ENSP00000359991Uterine CancerTreatment (none vs. Suberonylanilide hydroxamic acid (SAHA) treatment)cell lineDown0.219179759
ENSP00000359991Pancreatic CancerNormal vs. CancertissueUp4.119199705

Hyperphosphorylation site
PGAM1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANPGAM1_HUMANkinase -> substrateRegPhos
PKN1_HUMANPGAM1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00010Glycolysis / Gluconeogenesis
hsa01100Metabolic pathways
hsa00260Glycine, serine and threonine metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolIDAcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0045730respiratory burstIDAbiological_process
GO:0016868intramolecular transferase activity, phosphotransfIEAmolecular_function
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0006110regulation of glycolysisIDAbiological_process
GO:0004083bisphosphoglycerate 2-phosphatase activityIEAmolecular_function
GO:0006096glycolysisTASbiological_process
GO:0004082bisphosphoglycerate mutase activityIEAmolecular_function
GO:0004619phosphoglycerate mutase activityIMPmolecular_function
GO:0006006glucose metabolic processTASbiological_process
GO:0043456regulation of pentose-phosphate shuntIDAbiological_process
GO:0006094gluconeogenesisTASbiological_process


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