Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ABI2_HUMAN
Description:abl-interactor 2 [Source:HGNC Symbol;Acc:24011]
Location:chr2 q33.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S244RTYSSsGSSGGPhosphoSitePlus
S221APSQQsPVRTAHPRD
S218RNMAPsQQSPVHPRD
Y213VVPNDyVPSPTPhosphoSitePlus
T463AIYDYtKDKEDSH3_1PhosphoSitePlus
S183TQKPPsPPMSGPhosphoSitePlus
S224RNMAPsQQSPVPhosphoSitePlus; phosphoELM
T178RTTPPtQKPPSPhosphoSitePlus
S227APSQQsPVRTAPhosphoSitePlus; phosphoELM; SysPTM
S216NDYVPsPTRNMPhosphoSitePlus; phosphoELM
Y241QRNRTySSSGSPhosphoSitePlus
T200HSPYRtLEPVRPhosphoSitePlus
T294PASRHtPPTIGHPRD
Y460KVVAIyDYTKDSH3_1PhosphoSitePlus
S301PTIGGsLPYRRHPRD
T218YVPSPtRNMAPPhosphoSitePlus
Y284HPVQFySMNRPHPRD
Y23ALFDSyTNLERPhoUPhosphoSitePlus
S233PVRTAsVNQRNPhosphoSitePlus
S196TLGRHsPYRTLPhosphoSitePlus
Y32ERVADyCENNYPhoUPhosphoSitePlus
Y371GGSLPyRRPPSPhosphoSitePlus
T361PASRHtPPTIGPhosphoSitePlus
S253GGSHPsSRSSSPhosphoSitePlus
S242RNRTYsSSGSSPhosphoSitePlus
S210NDYVPsPTRNMHPRD
S368PTIGGsLPYRRPhosphoSitePlus
T297RHTPPtIGGSLHPRD
T240NQRNRtYSSSGPhosphoSitePlus
Y198GRHSPyRTLEPPhosphoSitePlus

Dephosphorylation site
ABI2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261016E394QBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
ABI2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ABI2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NEK9_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
STYK1_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
SLTM_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ABI2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006928cellular component movementIDAbiological_process
GO:0005913cell-cell adherens junctionIEAcellular_component
GO:0016358dendrite developmentIEAbiological_process
GO:0008093cytoskeletal adaptor activityTASmolecular_function
GO:0008154actin polymerization or depolymerizationNASbiological_process
GO:0030175filopodiumIDAcellular_component
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0070064proline-rich region bindingIPImolecular_function
GO:0017124SH3 domain bindingIPImolecular_function
GO:0005856cytoskeletonIEAcellular_component
GO:0007010cytoskeleton organizationTASbiological_process
GO:0019900kinase bindingNASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0003677DNA bindingTASmolecular_function
GO:0016477cell migrationTASbiological_process
GO:0043010camera-type eye developmentIEAbiological_process
GO:0016477cell migrationIEAbiological_process
GO:0005829cytosolIDAcellular_component
GO:0030425dendriteIEAcellular_component
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0007611learning or memoryIEAbiological_process
GO:0030027lamellipodiumIDAcellular_component


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