Phosphorylation

You are querying signaling transduction network mediated by PF2R_HUMAN in Intestines Cancer.

Signaling Transduction Network:

NO.	Source	Target	Relation Attribute	Resource
1	PGH2_HUMAN	PF2R_HUMAN	ligand -> receptor	HPMR
2	PF2R_HUMAN	GNAQ_HUMAN	GPCR -> Gprotein	gpDB
3	PF2R_HUMAN	GNA11_HUMAN	GPCR -> Gprotein	gpDB
4	GNAQ_HUMAN	BTK_HUMAN	Gprotein -> effector	gpDB
5	GNAQ_HUMAN	KPCD1_HUMAN	Gprotein -> effector	gpDB
6	GNAQ_HUMAN	ARBK1_HUMAN	Gprotein -> effector	gpDB
7	GNAQ_HUMAN	PK3CA_HUMAN	Gprotein -> effector	gpDB
8	GNA11_HUMAN	ARBK1_HUMAN	Gprotein -> effector	gpDB
9	BTK_HUMAN	FGR_HUMAN	kinase -> substrate	Robert H Newman (2013)
10	BTK_HUMAN	MK08_HUMAN	kinase -> substrate	Robert H Newman (2013)
11	KPCD1_HUMAN	KSYK_HUMAN	kinase -> substrate	NetPath
12	BTK_HUMAN	MK01_HUMAN	kinase -> substrate	Robert H Newman (2013)
13	BTK_HUMAN	KPCA_HUMAN	kinase -> substrate	Robert H Newman (2013)
14	ARBK1_HUMAN	P53_HUMAN	kinase -> substrate	Robert H Newman (2013)
15	BTK_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
16	BTK_HUMAN	STA5B_HUMAN	kinase -> substrate	Robert H Newman (2013)
17	PK3CA_HUMAN	KS6B1_HUMAN	kinase -> substrate	HPRD
18	BTK_HUMAN	HNRPK_HUMAN	kinase -> substrate	Robert H Newman (2013)
19	BTK_HUMAN	GTF2I_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
20	BTK_HUMAN	KKCC1_HUMAN	kinase -> substrate	Robert H Newman (2013)
21	BTK_HUMAN	STA5A_HUMAN	kinase -> substrate	HPRD; RegPhos
22	BTK_HUMAN	SMAD3_HUMAN	kinase -> substrate	Robert H Newman (2013)
23	BTK_HUMAN	CDK9_HUMAN	kinase -> substrate	Robert H Newman (2013)
24	BTK_HUMAN	ITK_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
25	FGR_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
26	MK08_HUMAN	JUN_HUMAN	kinase -> substrate; other	NetPath; Robert H Newman (2013); KEGG
27	KSYK_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
28	MK08_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
29	FGR_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
30	MK01_HUMAN	THB_HUMAN	kinase -> substrate	Robert H Newman (2013)
31	KPCA_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
32	KPCA_HUMAN	FOS_HUMAN	kinase -> substrate	HPRD
33	MK01_HUMAN	MYB_HUMAN	kinase -> substrate	HPRD
34	P53_HUMAN	BBC3_HUMAN	TF -> target gene	TRANSFAC
35	KPCA_HUMAN	PTN7_HUMAN	kinase -> substrate	HPRD
36	KS6A2_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
37	KS6A2_HUMAN	NR4A1_HUMAN	kinase -> substrate	RegPhos
38	MK01_HUMAN	SP1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
39	KPCA_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
40	KSYK_HUMAN	MK03_HUMAN	kinase -> substrate	NetPath
41	KS6A2_HUMAN	KS6A1_HUMAN	kinase -> substrate	RegPhos
42	MK08_HUMAN	MITF_HUMAN	kinase -> substrate	Robert H Newman (2013)
43	MK01_HUMAN	PKN1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
44	KPCA_HUMAN	EP300_HUMAN	kinase -> substrate	Robert H Newman (2013)
45	KPCA_HUMAN	STK11_HUMAN	kinase -> substrate	HPRD
46	MK01_HUMAN	FOS_HUMAN	kinase -> substrate; other	KEGG
47	KS6A2_HUMAN	SRF_HUMAN	kinase -> substrate	RegPhos
48	MK08_HUMAN	ATF2_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
49	MK08_HUMAN	MYC_HUMAN	kinase -> substrate	RegPhos
50	KS6A2_HUMAN	CEBPB_HUMAN	kinase -> substrate	RegPhos
51	KS6A2_HUMAN	TF65_HUMAN	kinase -> substrate	Robert H Newman (2013)
52	KS6B1_HUMAN	HSF1_HUMAN	kinase -> substrate	Robert H Newman (2013)
53	MK01_HUMAN	TF65_HUMAN	kinase -> substrate	Robert H Newman (2013)
54	MK01_HUMAN	SOS1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
55	FGR_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
56	MK08_HUMAN	PAX2_HUMAN	kinase -> substrate	NetPath
57	MK08_HUMAN	DYR1B_HUMAN	kinase -> substrate	Robert H Newman (2013)
58	MK01_HUMAN	MP2K1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
59	HNRPK_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
60	MK08_HUMAN	ELK1_HUMAN	kinase -> substrate	KEGG; Robert H Newman (2013)
61	MK01_HUMAN	GSK3B_HUMAN	kinase -> substrate	Robert H Newman (2013)
62	MK08_HUMAN	NFAC4_HUMAN	kinase -> substrate	KEGG
63	KS6A2_HUMAN	CREB1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
64	KPCA_HUMAN	ATF1_HUMAN	kinase -> substrate	HPRD
65	MK01_HUMAN	KS6A1_HUMAN	kinase -> substrate	HPRD
66	MK01_HUMAN	NR4A1_HUMAN	kinase -> substrate	HPRD
67	KPCA_HUMAN	GSK3A_HUMAN	kinase -> substrate	HPRD
68	MK01_HUMAN	BCL6_HUMAN	kinase -> substrate	NetPath
69	FGR_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
70	KKCC1_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
71	MK01_HUMAN	CEBPA_HUMAN	kinase -> substrate	Robert H Newman (2013)
72	MK08_HUMAN	ELK3_HUMAN	kinase -> substrate	HPRD; RegPhos
73	FGR_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
74	MK01_HUMAN	TFE2_HUMAN	kinase -> substrate	HPRD; NetPath
75	MK01_HUMAN	PRGR_HUMAN	kinase -> substrate	Robert H Newman (2013)
76	KPCA_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
77	MK08_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
78	KPCA_HUMAN	CREM_HUMAN	kinase -> substrate	HPRD
79	MK01_HUMAN	STF1_HUMAN	kinase -> substrate	HPRD
80	MK01_HUMAN	MYC_HUMAN	kinase -> substrate	KEGG; Robert H Newman (2013)
81	FGR_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
82	KS6B1_HUMAN	MTOR_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
83	MK01_HUMAN	JUN_HUMAN	kinase -> substrate	KEGG
84	KSYK_HUMAN	KS6A1_HUMAN	kinase -> substrate	NetPath
85	P53_HUMAN	ATF3_HUMAN	TF -> target gene	TRANSFAC
86	KPCA_HUMAN	GSK3B_HUMAN	kinase -> substrate	KEGG; HPRD
87	STA5A_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
88	MK01_HUMAN	ELK1_HUMAN	kinase -> substrate	NetPath
89	MK01_HUMAN	PTN7_HUMAN	kinase -> substrate	HPRD
90	MK08_HUMAN	NFAC2_HUMAN	kinase -> substrate	KEGG
91	P53_HUMAN	P73_HUMAN	TF -> target gene	KEGG; TRANSFAC
92	MK01_HUMAN	GCR_HUMAN	kinase -> substrate	HPRD
93	KS6A2_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
94	KPCA_HUMAN	GLI1_HUMAN	kinase -> substrate	KEGG
95	MK08_HUMAN	GCR_HUMAN	kinase -> substrate	HPRD; RegPhos
96	KS6B1_HUMAN	STK11_HUMAN	kinase -> substrate	HPRD
97	MK01_HUMAN	ELK4_HUMAN	kinase -> substrate	KEGG
98	KS6A2_HUMAN	CSEN_HUMAN	kinase -> substrate	Robert H Newman (2013)
99	GTF2I_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
100	KPCA_HUMAN	AHR_HUMAN	kinase -> substrate	Robert H Newman (2013)
101	MK08_HUMAN	PPARA_HUMAN	kinase -> substrate	Robert H Newman (2013)
102	SMAD3_HUMAN	JUN_HUMAN	TF -> target gene	TRANSFAC
103	KS6B1_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
104	MK01_HUMAN	PPARA_HUMAN	kinase -> substrate	HPRD
105	MK08_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
106	FGR_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
107	MK01_HUMAN	MITF_HUMAN	kinase -> substrate	NetPath
108	MK01_HUMAN	SRBP2_HUMAN	kinase -> substrate	Robert H Newman (2013)
109	KPCA_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
110	MK01_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
111	KS6A2_HUMAN	GABPA_HUMAN	kinase -> substrate	Robert H Newman (2013)
112	MK01_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
113	KPCA_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
114	MK01_HUMAN	RXRA_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
115	KPCA_HUMAN	ATF4_HUMAN	kinase -> substrate	KEGG
116	KPCA_HUMAN	KLF1_HUMAN	kinase -> substrate	HPRD
117	P53_HUMAN	P63_HUMAN	TF -> target gene	TRANSFAC
118	KPCA_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD
119	CDK9_HUMAN	CHK2_HUMAN	kinase -> substrate	Robert H Newman (2013)
120	KS6B1_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
121	MK08_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
122	KS6A2_HUMAN	FOS_HUMAN	kinase -> substrate	RegPhos
123	ITK_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
124	KPCA_HUMAN	MYOD1_HUMAN	kinase -> substrate	HPRD
125	MK08_HUMAN	HSF1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
126	MK08_HUMAN	JUND_HUMAN	kinase -> substrate	KEGG
127	MK01_HUMAN	CEBPB_HUMAN	kinase -> substrate	HPRD
128	MK01_HUMAN	SRBP1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
129	KPCA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD
130	MK01_HUMAN	SMAD4_HUMAN	kinase -> substrate	HPRD
131	MK01_HUMAN	STK16_HUMAN	kinase -> substrate	Robert H Newman (2013)
132	MK08_HUMAN	FOS_HUMAN	kinase -> substrate	KEGG
133	RXRA_HUMAN	RARB_HUMAN	TF -> target gene	TRANSFAC
134	SRF_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
135	CSK21_HUMAN	HIF1A_HUMAN	kinase -> substrate	HPRD
136	PTN7_HUMAN	MK14_HUMAN	phosphatase -> substrate	KEGG
137	SP1_HUMAN	PHX2A_HUMAN	TF -> target gene	TRANSFAC
138	SP1_HUMAN	REL_HUMAN	TF -> target gene	TRANSFAC
139	MK03_HUMAN	MAZ_HUMAN	kinase -> substrate	Robert H Newman (2013)
140	SP1_HUMAN	HNF4A_HUMAN	TF -> target gene	TRANSFAC
141	KS6A1_HUMAN	ESR2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
142	PKN1_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
143	CSK21_HUMAN	MYF6_HUMAN	kinase -> substrate	Robert H Newman (2013)
144	STK11_HUMAN	SIK2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
145	SRF_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
146	MYC_HUMAN	CDK4_HUMAN	TF -> target gene	TRANSFAC
147	CSK21_HUMAN	MEF2A_HUMAN	kinase -> substrate	Robert H Newman (2013)
148	DYR1B_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
149	MP2K1_HUMAN	KS6A4_HUMAN	kinase -> substrate	RegPhos
150	ELK1_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
151	GSK3B_HUMAN	CDX2_HUMAN	kinase -> substrate	RegPhos
152	CSK21_HUMAN	HMGA1_HUMAN	kinase -> substrate	HPRD
153	ATF1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
154	CREB1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
155	NR4A1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
156	CSK21_HUMAN	MYF5_HUMAN	kinase -> substrate	HPRD
157	GSK3A_HUMAN	TF7L2_HUMAN	kinase -> substrate	Robert H Newman (2013)
158	SP1_HUMAN	CDK2_HUMAN	TF -> target gene	TRANSFAC
159	STK11_HUMAN	TFE3_HUMAN	kinase -> substrate	Robert H Newman (2013)
160	PRGR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
161	SP1_HUMAN	SP3_HUMAN	TF -> target gene	TRANSFAC
162	CREB1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
163	FOXO4_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
164	MTOR_HUMAN	HIF1A_HUMAN	kinase -> substrate	KEGG
165	SP1_HUMAN	MAZ_HUMAN	TF -> target gene	TRANSFAC
166	STK11_HUMAN	SIK3_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
167	NFAC2_HUMAN	EGR3_HUMAN	TF -> target gene	TRANSFAC
168	SP1_HUMAN	RARA_HUMAN	TF -> target gene	TRANSFAC
169	STK11_HUMAN	SIK1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
170	ZAP70_HUMAN	MK14_HUMAN	kinase -> substrate	KEGG; RegPhos; Robert H Newman (2013)
171	CSK21_HUMAN	APEX1_HUMAN	kinase -> substrate	HPRD
172	CSK21_HUMAN	MAZ_HUMAN	kinase -> substrate	HPRD
173	SP1_HUMAN	AP2C_HUMAN	TF -> target gene	TRANSFAC
174	SP1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
175	CSK21_HUMAN	TF7L2_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
176	CHK2_HUMAN	E2F1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
177	SP1_HUMAN	TGFR2_HUMAN	TF -> target gene	TRANSFAC
178	DYR1B_HUMAN	HNF1A_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
179	CSK21_HUMAN	NKX25_HUMAN	kinase -> substrate	HPRD
180	GCR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
181	STK16_HUMAN	IRF5_HUMAN	kinase -> substrate	Robert H Newman (2013)
182	CSK21_HUMAN	EGR1_HUMAN	kinase -> substrate	HPRD
183	PRDM1_HUMAN	PAX5_HUMAN	TF -> target gene	TRANSFAC
184	SIK2_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
185	CDK4_HUMAN	FOXN2_HUMAN	kinase -> substrate	Robert H Newman (2013)
186	KS6A4_HUMAN	PO6F1_HUMAN	kinase -> substrate	Robert H Newman (2013)
187	CDK2_HUMAN	TFDP1_HUMAN	kinase -> substrate	RegPhos
188	CDK4_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
189	SIK3_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
190	SIK1_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
191	MEF2A_HUMAN	MYOG_HUMAN	TF -> target gene	TRANSFAC
192	TGFR2_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
193	CDK2_HUMAN	NFYA_HUMAN	kinase -> substrate	HPRD
194	GLHA_HUMAN	PF2R_HUMAN	other	KEGG

⁺Protein attribute:

protein with cancer-related variations (CanProVar)

up expressed protein;

down expressed protein(dbDEPC)

protein with hyperphosphorylation site (PhosphoSitePlus)

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network