Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PGH2_HUMAN
Description:prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [Source:HGNC Symbol;Acc:9605]
Location:chr1 q31.1
Node attribute:ligand; PPI(target)

Phosphorylation site
PGH2_HUMAN do not have phosphorylation site.

Dephosphorylation site
PGH2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356438P427SCOSMICCentral Nervous System Neoplasms18772396
ENSP00000356438Q382ECOSMICHead and Neck Cancer21798893
ENSP00000356438E496KCOSMICSkin Cancer21984974
ENSP00000356438C21*BIOMARTBreast Cancer21930507, 21930502
ENSP00000356438Q435LCOSMICHead and Neck Cancer21798893
ENSP00000356438G283SCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000356438Pancreatic CancerTreatment (none vs. IL-1 treatment)cell lineUp219513556
ENSP00000356438Pancreatic CancerTreatment (none vs. IL-1 treatment)cell lineUp3.219513556
ENSP00000356438Pancreatic CancerTreatment (none vs. IL-1 treatment)cell lineUp3.419513556
ENSP00000356438Pancreatic CancerTreatment (none vs. IL-1 treatment)cell lineUp3.519513556

Hyperphosphorylation site
PGH2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PGH2_HUMANPF2R_HUMANligand -> receptorHPMR
PGH2_HUMANPD2R2_HUMANligand -> receptorHPMR
NFAT5_HUMANPGH2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05140Leishmaniasis
hsa04723Retrograde endocannabinoid signaling
hsa05200Pathways in cancer
hsa04726Serotonergic synapse
hsa00590Arachidonic acid metabolism
hsa04064NF-kappa B signaling pathway
hsa04370VEGF signaling pathway
hsa05222Small cell lung cancer
hsa01100Metabolic pathways

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045986negative regulation of smooth muscle contractionIEAbiological_process
GO:0090271positive regulation of fibroblast growth factor prISSbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0051968positive regulation of synaptic transmission, glutIEAbiological_process
GO:0045429positive regulation of nitric oxide biosynthetic pIEAbiological_process
GO:0006979response to oxidative stressIEAbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0030728ovulationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0010226response to lithium ionIEAbiological_process
GO:0010575positive regulation vascular endothelial growth faISSbiological_process
GO:0045786negative regulation of cell cycleIEAbiological_process
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0048661positive regulation of smooth muscle cell proliferIEAbiological_process
GO:0019371cyclooxygenase pathwayIDAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0090271positive regulation of fibroblast growth factor prIEAbiological_process
GO:0090336positive regulation of brown fat cell differentiatISSbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0019371cyclooxygenase pathwayIEAbiological_process
GO:0019233sensory perception of painIEAbiological_process
GO:0071636positive regulation of transforming growth factor IEAbiological_process
GO:0008217regulation of blood pressureIEAbiological_process
GO:0010243response to organic nitrogenIEAbiological_process
GO:0004666prostaglandin-endoperoxide synthase activityIDAmolecular_function
GO:0033280response to vitamin DIEAbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0055114oxidation-reduction processIEAbiological_process
GO:0009314response to radiationIEAbiological_process
GO:0007566embryo implantationIEAbiological_process
GO:0030282bone mineralizationIEAbiological_process
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0006693prostaglandin metabolic processTASbiological_process
GO:0010942positive regulation of cell deathIEAbiological_process
GO:0031622positive regulation of fever generationIEAbiological_process
GO:0070542response to fatty acidIEAbiological_process
GO:0004601peroxidase activityNASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0001516prostaglandin biosynthetic processIEAbiological_process
GO:0020037heme bindingISSmolecular_function
GO:0071260cellular response to mechanical stimulusIEAbiological_process
GO:0004666prostaglandin-endoperoxide synthase activityIEAmolecular_function
GO:0031915positive regulation of synaptic plasticityIEAbiological_process
GO:0045429positive regulation of nitric oxide biosynthetic pISSbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0042633hair cycleIEAbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0090362positive regulation of platelet-derived growth facIEAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0043005neuron projectionIDAcellular_component
GO:0043005neuron projectionIEAcellular_component
GO:0016702oxidoreductase activity, acting on single donors wIEAmolecular_function
GO:0005737cytoplasmISScellular_component
GO:0006928cellular component movementTASbiological_process
GO:0042640anagenIEAbiological_process
GO:0050727regulation of inflammatory responseNASbiological_process
GO:0005788endoplasmic reticulum lumenTAScellular_component
GO:0051926negative regulation of calcium ion transportIEAbiological_process
GO:0001516prostaglandin biosynthetic processISSbiological_process
GO:0035633maintenance of blood-brain barrierIEAbiological_process
GO:0007613memoryIEAbiological_process
GO:0032355response to estradiol stimulusIEAbiological_process
GO:0009750response to fructose stimulusIEAbiological_process
GO:0034612response to tumor necrosis factorIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0005634nucleusISScellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0031394positive regulation of prostaglandin biosynthetic NASbiological_process
GO:0071636positive regulation of transforming growth factor ISSbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0046697decidualizationIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0090362positive regulation of platelet-derived growth facISSbiological_process
GO:0090050positive regulation of cell migration involved in ISSbiological_process
GO:0006805xenobiotic metabolic processTASbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0071318cellular response to ATPIEAbiological_process
GO:0010042response to manganese ionIEAbiological_process
GO:0071456cellular response to hypoxiaIEPbiological_process
GO:0090336positive regulation of brown fat cell differentiatIEAbiological_process
GO:0042346positive regulation of NF-kappaB import into nucleIEAbiological_process
GO:0090050positive regulation of cell migration involved in IEAbiological_process
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0050873brown fat cell differentiationIEAbiological_process
GO:0034644cellular response to UVIEAbiological_process
GO:0008217regulation of blood pressureISSbiological_process
GO:0045987positive regulation of smooth muscle contractionIEAbiological_process
GO:0007612learningIEAbiological_process
GO:0010575positive regulation vascular endothelial growth faIEAbiological_process
GO:0020037heme bindingIEAmolecular_function
GO:0008289lipid bindingIEAmolecular_function
GO:0045907positive regulation of vasoconstrictionIEAbiological_process
GO:0032227negative regulation of synaptic transmission, dopaIEAbiological_process
GO:0031622positive regulation of fever generationISSbiological_process