Phosphorylation

You are querying signaling transduction network mediated by ACM5_HUMAN in Intestines Cancer.

Signaling Transduction Network:

NO.	Source	Target	Relation Attribute	Resource
1	CLAT_HUMAN	ACM5_HUMAN	ligand -> receptor	HPMR
2	ACM5_HUMAN	GNAQ_HUMAN	GPCR -> Gprotein	gpDB
3	ACM5_HUMAN	GNA11_HUMAN	GPCR -> Gprotein	gpDB
4	GNAQ_HUMAN	BTK_HUMAN	Gprotein -> effector	gpDB
5	GNAQ_HUMAN	ARBK1_HUMAN	Gprotein -> effector	gpDB
6	GNAQ_HUMAN	PK3CA_HUMAN	Gprotein -> effector	gpDB
7	GNA11_HUMAN	ARBK1_HUMAN	Gprotein -> effector	gpDB
8	GNAQ_HUMAN	KPCD1_HUMAN	Gprotein -> effector	gpDB
9	BTK_HUMAN	MK08_HUMAN	kinase -> substrate	Robert H Newman (2013)
10	BTK_HUMAN	MK01_HUMAN	kinase -> substrate	Robert H Newman (2013)
11	BTK_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
12	ARBK1_HUMAN	P53_HUMAN	kinase -> substrate	Robert H Newman (2013)
13	BTK_HUMAN	KPCA_HUMAN	kinase -> substrate	Robert H Newman (2013)
14	BTK_HUMAN	STA5A_HUMAN	kinase -> substrate	HPRD; RegPhos
15	PK3CA_HUMAN	KS6B1_HUMAN	kinase -> substrate	HPRD
16	BTK_HUMAN	FGR_HUMAN	kinase -> substrate	Robert H Newman (2013)
17	BTK_HUMAN	GTF2I_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
18	BTK_HUMAN	HNRPK_HUMAN	kinase -> substrate	Robert H Newman (2013)
19	BTK_HUMAN	CDK9_HUMAN	kinase -> substrate	Robert H Newman (2013)
20	BTK_HUMAN	KKCC1_HUMAN	kinase -> substrate	Robert H Newman (2013)
21	BTK_HUMAN	ITK_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
22	KPCD1_HUMAN	KSYK_HUMAN	kinase -> substrate	NetPath
23	BTK_HUMAN	STA5B_HUMAN	kinase -> substrate	Robert H Newman (2013)
24	BTK_HUMAN	SMAD3_HUMAN	kinase -> substrate	Robert H Newman (2013)
25	MK08_HUMAN	MITF_HUMAN	kinase -> substrate	Robert H Newman (2013)
26	MK01_HUMAN	SP1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
27	KS6A2_HUMAN	CREB1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
28	MK08_HUMAN	JUND_HUMAN	kinase -> substrate	KEGG
29	P53_HUMAN	P63_HUMAN	TF -> target gene	TRANSFAC
30	KS6A2_HUMAN	CEBPB_HUMAN	kinase -> substrate	RegPhos
31	MK01_HUMAN	SRBP1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
32	MK08_HUMAN	ELK1_HUMAN	kinase -> substrate	KEGG; Robert H Newman (2013)
33	MK08_HUMAN	DYR1B_HUMAN	kinase -> substrate	Robert H Newman (2013)
34	KS6A2_HUMAN	GABPA_HUMAN	kinase -> substrate	Robert H Newman (2013)
35	KPCA_HUMAN	AHR_HUMAN	kinase -> substrate	Robert H Newman (2013)
36	MK08_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
37	MK01_HUMAN	STF1_HUMAN	kinase -> substrate	HPRD
38	STA5A_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
39	KPCA_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
40	MK01_HUMAN	BCL6_HUMAN	kinase -> substrate	NetPath
41	KS6B1_HUMAN	STK11_HUMAN	kinase -> substrate	HPRD
42	MK01_HUMAN	ELK4_HUMAN	kinase -> substrate	KEGG
43	MK01_HUMAN	FOS_HUMAN	kinase -> substrate; other	KEGG
44	FGR_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
45	MK08_HUMAN	HSF1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
46	MK01_HUMAN	PRGR_HUMAN	kinase -> substrate	Robert H Newman (2013)
47	KPCA_HUMAN	GLI1_HUMAN	kinase -> substrate	KEGG
48	MK08_HUMAN	MYC_HUMAN	kinase -> substrate	RegPhos
49	MK01_HUMAN	NR4A1_HUMAN	kinase -> substrate	HPRD
50	KPCA_HUMAN	MYOD1_HUMAN	kinase -> substrate	HPRD
51	KS6B1_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
52	MK01_HUMAN	GSK3B_HUMAN	kinase -> substrate	Robert H Newman (2013)
53	MK08_HUMAN	NFAC2_HUMAN	kinase -> substrate	KEGG
54	KS6A2_HUMAN	NR4A1_HUMAN	kinase -> substrate	RegPhos
55	P53_HUMAN	P73_HUMAN	TF -> target gene	KEGG; TRANSFAC
56	MK08_HUMAN	ATF2_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
57	KS6A2_HUMAN	SRF_HUMAN	kinase -> substrate	RegPhos
58	KS6A2_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
59	MK01_HUMAN	SRBP2_HUMAN	kinase -> substrate	Robert H Newman (2013)
60	P53_HUMAN	ATF3_HUMAN	TF -> target gene	TRANSFAC
61	MK01_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
62	MK08_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
63	FGR_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
64	KS6A2_HUMAN	TF65_HUMAN	kinase -> substrate	Robert H Newman (2013)
65	KPCA_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
66	KPCA_HUMAN	FOS_HUMAN	kinase -> substrate	HPRD
67	MK01_HUMAN	CEBPA_HUMAN	kinase -> substrate	Robert H Newman (2013)
68	FGR_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
69	FGR_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
70	MK01_HUMAN	ELK1_HUMAN	kinase -> substrate	NetPath
71	MK08_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
72	KPCA_HUMAN	STK11_HUMAN	kinase -> substrate	HPRD
73	MK08_HUMAN	NFAC4_HUMAN	kinase -> substrate	KEGG
74	MK01_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
75	KS6A2_HUMAN	KS6A1_HUMAN	kinase -> substrate	RegPhos
76	KPCA_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
77	FGR_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
78	HNRPK_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
79	CDK9_HUMAN	CHK2_HUMAN	kinase -> substrate	Robert H Newman (2013)
80	MK01_HUMAN	RXRA_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
81	MK08_HUMAN	PPARA_HUMAN	kinase -> substrate	Robert H Newman (2013)
82	KPCA_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
83	KPCA_HUMAN	KLF1_HUMAN	kinase -> substrate	HPRD
84	MK01_HUMAN	JUN_HUMAN	kinase -> substrate	KEGG
85	KPCA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD
86	KS6A2_HUMAN	CSEN_HUMAN	kinase -> substrate	Robert H Newman (2013)
87	KPCA_HUMAN	PTN7_HUMAN	kinase -> substrate	HPRD
88	MK01_HUMAN	STK16_HUMAN	kinase -> substrate	Robert H Newman (2013)
89	KPCA_HUMAN	GSK3B_HUMAN	kinase -> substrate	KEGG; HPRD
90	KPCA_HUMAN	ATF1_HUMAN	kinase -> substrate	HPRD
91	MK01_HUMAN	GCR_HUMAN	kinase -> substrate	HPRD
92	KPCA_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
93	MK01_HUMAN	MYC_HUMAN	kinase -> substrate	KEGG; Robert H Newman (2013)
94	MK01_HUMAN	PKN1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
95	MK01_HUMAN	CEBPB_HUMAN	kinase -> substrate	HPRD
96	KPCA_HUMAN	CREM_HUMAN	kinase -> substrate	HPRD
97	MK01_HUMAN	PPARA_HUMAN	kinase -> substrate	HPRD
98	MK08_HUMAN	ELK3_HUMAN	kinase -> substrate	HPRD; RegPhos
99	KKCC1_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
100	ITK_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
101	KSYK_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
102	KPCA_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD
103	KS6A2_HUMAN	FOS_HUMAN	kinase -> substrate	RegPhos
104	P53_HUMAN	BBC3_HUMAN	TF -> target gene	TRANSFAC
105	SMAD3_HUMAN	JUN_HUMAN	TF -> target gene	TRANSFAC
106	MK08_HUMAN	GCR_HUMAN	kinase -> substrate	HPRD; RegPhos
107	KPCA_HUMAN	GSK3A_HUMAN	kinase -> substrate	HPRD
108	FGR_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
109	MK01_HUMAN	TFE2_HUMAN	kinase -> substrate	HPRD; NetPath
110	MK01_HUMAN	TF65_HUMAN	kinase -> substrate	Robert H Newman (2013)
111	KPCA_HUMAN	EP300_HUMAN	kinase -> substrate	Robert H Newman (2013)
112	KPCA_HUMAN	ATF4_HUMAN	kinase -> substrate	KEGG
113	MK01_HUMAN	PTN7_HUMAN	kinase -> substrate	HPRD
114	MK01_HUMAN	MYB_HUMAN	kinase -> substrate	HPRD
115	KSYK_HUMAN	MK03_HUMAN	kinase -> substrate	NetPath
116	MK08_HUMAN	FOS_HUMAN	kinase -> substrate	KEGG
117	KS6B1_HUMAN	HSF1_HUMAN	kinase -> substrate	Robert H Newman (2013)
118	MK08_HUMAN	JUN_HUMAN	kinase -> substrate; other	NetPath; Robert H Newman (2013); KEGG
119	FGR_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
120	KS6B1_HUMAN	MTOR_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
121	KS6A2_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
122	GTF2I_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
123	KSYK_HUMAN	KS6A1_HUMAN	kinase -> substrate	NetPath
124	MK01_HUMAN	MP2K1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
125	KS6B1_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
126	MK01_HUMAN	SMAD4_HUMAN	kinase -> substrate	HPRD
127	MK01_HUMAN	MITF_HUMAN	kinase -> substrate	NetPath
128	MK01_HUMAN	KS6A1_HUMAN	kinase -> substrate	HPRD
129	MK08_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
130	MK01_HUMAN	THB_HUMAN	kinase -> substrate	Robert H Newman (2013)
131	MK08_HUMAN	PAX2_HUMAN	kinase -> substrate	NetPath
132	MK01_HUMAN	SOS1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
133	SP1_HUMAN	HNF4A_HUMAN	TF -> target gene	TRANSFAC
134	CREB1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
135	ELK1_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
136	DYR1B_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
137	SRF_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
138	STK11_HUMAN	TFE3_HUMAN	kinase -> substrate	Robert H Newman (2013)
139	CSK21_HUMAN	MEF2A_HUMAN	kinase -> substrate	Robert H Newman (2013)
140	DYR1B_HUMAN	HNF1A_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
141	CSK21_HUMAN	MAZ_HUMAN	kinase -> substrate	HPRD
142	SP1_HUMAN	PHX2A_HUMAN	TF -> target gene	TRANSFAC
143	SP1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
144	PRGR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
145	SP1_HUMAN	MAZ_HUMAN	TF -> target gene	TRANSFAC
146	SP1_HUMAN	AP2C_HUMAN	TF -> target gene	TRANSFAC
147	NR4A1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
148	SP1_HUMAN	RARA_HUMAN	TF -> target gene	TRANSFAC
149	GSK3B_HUMAN	CDX2_HUMAN	kinase -> substrate	RegPhos
150	CREB1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
151	SP1_HUMAN	TGFR2_HUMAN	TF -> target gene	TRANSFAC
152	CSK21_HUMAN	HIF1A_HUMAN	kinase -> substrate	HPRD
153	STK11_HUMAN	SIK3_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
154	KS6A1_HUMAN	ESR2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
155	CSK21_HUMAN	NKX25_HUMAN	kinase -> substrate	HPRD
156	SP1_HUMAN	REL_HUMAN	TF -> target gene	TRANSFAC
157	MYC_HUMAN	CDK4_HUMAN	TF -> target gene	TRANSFAC
158	STK11_HUMAN	SIK2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
159	CHK2_HUMAN	E2F1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
160	STK11_HUMAN	SIK1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
161	CSK21_HUMAN	APEX1_HUMAN	kinase -> substrate	HPRD
162	RXRA_HUMAN	RARB_HUMAN	TF -> target gene	TRANSFAC
163	CSK21_HUMAN	EGR1_HUMAN	kinase -> substrate	HPRD
164	PTN7_HUMAN	MK14_HUMAN	phosphatase -> substrate	KEGG
165	STK16_HUMAN	IRF5_HUMAN	kinase -> substrate	Robert H Newman (2013)
166	CSK21_HUMAN	MYF5_HUMAN	kinase -> substrate	HPRD
167	SRF_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
168	PKN1_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
169	CSK21_HUMAN	HMGA1_HUMAN	kinase -> substrate	HPRD
170	SP1_HUMAN	SP3_HUMAN	TF -> target gene	TRANSFAC
171	SP1_HUMAN	CDK2_HUMAN	TF -> target gene	TRANSFAC
172	GCR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
173	GSK3A_HUMAN	TF7L2_HUMAN	kinase -> substrate	Robert H Newman (2013)
174	NFAC2_HUMAN	EGR3_HUMAN	TF -> target gene	TRANSFAC
175	ZAP70_HUMAN	MK14_HUMAN	kinase -> substrate	KEGG; RegPhos; Robert H Newman (2013)
176	ATF1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
177	MK03_HUMAN	MAZ_HUMAN	kinase -> substrate	Robert H Newman (2013)
178	FOXO4_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
179	MTOR_HUMAN	HIF1A_HUMAN	kinase -> substrate	KEGG
180	MP2K1_HUMAN	KS6A4_HUMAN	kinase -> substrate	RegPhos
181	CSK21_HUMAN	MYF6_HUMAN	kinase -> substrate	Robert H Newman (2013)
182	CSK21_HUMAN	TF7L2_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
183	TGFR2_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
184	SIK3_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
185	CDK4_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
186	SIK2_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
187	SIK1_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
188	CDK4_HUMAN	FOXN2_HUMAN	kinase -> substrate	Robert H Newman (2013)
189	PRDM1_HUMAN	PAX5_HUMAN	TF -> target gene	TRANSFAC
190	MEF2A_HUMAN	MYOG_HUMAN	TF -> target gene	TRANSFAC
191	CDK2_HUMAN	TFDP1_HUMAN	kinase -> substrate	RegPhos
192	CDK2_HUMAN	NFYA_HUMAN	kinase -> substrate	HPRD
193	KS6A4_HUMAN	PO6F1_HUMAN	kinase -> substrate	Robert H Newman (2013)

⁺Protein attribute:

protein with cancer-related variations (CanProVar)

up expressed protein;

down expressed protein(dbDEPC)

protein with hyperphosphorylation site (PhosphoSitePlus)

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network