| UniProt/SwissProt ID: | ACM5_HUMAN |
| Description: | cholinergic receptor, muscarinic 5 [Source:HGNC Symbol;Acc:1954] |
| Location: | chr15 q14 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S277 | SSSRRsTSTTG | 7tm_1 | PhosphoSitePlus |
| S414 | VAKEPsTKGLN | 7tm_1 | PhosphoSitePlus |
| T427 | PSHQMtKRKRV | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| ACM5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000372750 | S274F | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000453745 | R142C | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000372750 | R142C | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000372750 | R142C | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| ACM5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ACM5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CLAT_HUMAN | ACM5_HUMAN | ligand -> receptor | HPMR |
| ACM5_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| ACM5_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04020 | Calcium signaling pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa04725 | Cholinergic synapse |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045211 | postsynaptic membrane | IEA | cellular_component |
| GO:0007213 | G-protein coupled acetylcholine receptor signaling | TAS | biological_process |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007197 | adenylate cyclase-inhibiting G-protein coupled ace | TAS | biological_process |
| GO:0019226 | transmission of nerve impulse | IEA | biological_process |
| GO:0016907 | G-protein coupled acetylcholine receptor activity | IEA | molecular_function |
| GO:0060304 | regulation of phosphatidylinositol dephosphorylati | IEA | biological_process |
| GO:0004435 | phosphatidylinositol phospholipase C activity | TAS | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0015872 | dopamine transport | IEA | biological_process |
| GO:0007213 | G-protein coupled acetylcholine receptor signaling | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0030054 | cell junction | IEA | cellular_component |