Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CTND1_HUMAN
Description:catenin (cadherin-associated protein), delta 1 [Source:HGNC Symbol;Acc:2515]
Location:chr11 q12.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T799DNNYStPNERGHPRD
T869SYDDStLPLIDPhosphoSitePlus; HPRD; phosphoELM
S778DRNQKsDKKPDHPRD
Y904SLDNNySTPNEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y296YDDLDyGMMSDPhosphoSitePlus; HPRD
Y213YPPDGySRHYEPhosphoSitePlus; HPRD
S857NLNNAsRSQSSPhosphoSitePlus
S349RGSLAsLDSLRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S784EEIQMsNMGSNHPRD
S861ASRSQsSHSYDPhosphoSitePlus
S914RTLDRsGDLGDHPRD
T906DNNYStPNERGPhosphoSitePlus; HPRD; phosphoELM
Y962GGQVSyPSMQKPhosphoSitePlus
T134SDDGTtRRTETPhosphoSitePlus
Y179FHPEPyGLEDDHPRD
S905LDNNYsTPNERPhosphoSitePlus
Y221HYEDGyPGGSDPhosphoSitePlus; HPRD
S777EDTVIsILNTIPhosphoSitePlus
T910GDHNRtLDRSGHPRD
T177NNYIQtLGRDFPhosphoSitePlus
Y334VPSDQyYWAPLPhosphoSitePlus; HPRD; RegPhos
Y395LQHLCyRNDKVPhosphoSitePlus
S168LPVDAsSVSNNPhosphoSitePlus
Y112QIVETyTEEDPSRCHPRD; RegPhos
Y758QSSHSyDDSTLHPRD
Y257SRQDVyGPQPQSRCHPRD; RegPhos
Y220RRLRSyEDMIGHPRD
Y764QSSHSyDDSTLHPRD
T832PLKGTtPLMQHPRD
S841EGWKKsDFQVNHPRD
S346QHERGsLASLDPhosphoSitePlus; HPRD
S731VVKAAsGALRNArmPhosphoSitePlus
T768SYDDStLPLIDHPRD
S288EDDQRsMGYDDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T98HLLYStIPRMQPhosphoSitePlus
T203MSDYGtARRTGHPRD
Y107PRNFHyPPDGYHPRD
S675SLLKEsKTPAIHPRD
S320RRRLRsYEDMIPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T27QFEKLtRALEEPhosphoSitePlus
S763SQSSHsYDDSTHPRD
T926EPLKGtTPLMQHPRD
T149VVKTVtTRTVQPhosphoSitePlus
T774NFSEDtVISILPhosphoSitePlus
S758NNASRsQSSHSHPRD
S38ERRHVsAQLERPhosphoSitePlus
S199DYGMMsDYGTAHPRD
S862SRSQSsHSYDDPhosphoSitePlus
Y120HYEDGyPGGSDHPRD
Y233VPSDQyYWAPLHPRD
S268VRVGGsSVDLHPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y195YDDLDyGMMSDHPRD
S187EDDQRsMGYDDHPRD
T933PLKGTtPLMQDphosphoELM
T619IADLLtNEHERHPRD
T613IADLLtNEHERHPRD
Y96HSHLLySTIPRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S792RTLDRsGDLGDHPRD
S4__MDDsEVESTPhosphoSitePlus
T59LMANGtLTRRHPhosphoSitePlus; HPRD
T809GDHNRtLDRSGHPRD
S858SQSSHsYDDSTHPRD
T199VGQAGtATLPRPhosphoSitePlus
Y291QRSMGyDDLDYPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S891EEIQMsNMGSNHPRD
S675SLLKEsKTPAIArmPhosphoSitePlus
T310ARRTGtPSDPRGSK3BHPRD; RegPhos
T826PLKGTtPLMQHPRD
S167VRVGGsSVDLHHPRD
Y865QSSHSyDDSTLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S151GYRAPsRQDVYHPRD
S539LRNVSsERSEAPhosphoSitePlus
S885EEIQMsNMGSNHPRD
Y241RIEERyRPSMEPhosphoSitePlus
T304MSDYGtARRTGPhosphoSitePlus; HPRD
S244ERYRPsMEGYRPhosphoSitePlus; HPRD; phosphoELM
S757SQSSHsYDDSTHPRD
Y803SLDNNySTPNEHPRD
T805DNNYStPNERGHPRD
S248RGSLAsLDSLRHPRD
T825EPLKGtTPLMQHPRD
Y73SVSNNyIQTLGHPRD
Y217GYSRHyEDGYPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S669SLLKEsKTPAIHPRD
Y797SLDNNySTPNEHPRD
S879DRNQKsDKKPDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S331GEEVPsDQYYWPhosphoSitePlus
S752NNASRsQSSHSHPRD
Y302GMMSDyGTARRSRCHPRD; RegPhos
S761HSYDDsTLPLIHPRD
S131NYGSLsRVTRIHPRD
S864SQSSHsYDDSTPhosphoSitePlus; HPRD
T308GTARRtGTPSDPhosphoSitePlus
S312RTGTPsDPRRRPhosphoSitePlus; HPRD; RegPhos
Y190QRSMGyDDLDYHPRD
S269RVGGSsVDLHRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y656SPARGyELLFQArmPhosphoSitePlus
S811VLINKsGNRSEPhosphoSitePlus; HPRD
T310ARRTGtPSDPRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S772DRNQKsDKKPDHPRD
S122PEGAMsVVSVEHPRD; RegPhos
Y208PRNFHyPPDGYPhosphoSitePlus; HPRD
S252GYRAPsRQDVYPhosphoSitePlus; HPRD
S47ERVRVsPQDANPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y280FHPEPyGLEDDSRCHPRD; RegPhos
Y600PQAERyQEAAPPhosphoSitePlus
Y201GMMSDyGTARRHPRD
T788GDHNRtLDRSGHPRD
S767HSYDDsTLPLIHPRD
S568SLLKEsKTPAIHPRD
S169PVDASsVSNNYPhosphoSitePlus
Y302GMMSDyGTARRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T815GDHNRtLDRSGHPRD
T927PLKGTtPLMQHPRD
T235SLSRVtRIEERPhosphoSitePlus
T720IADLLtNEHERArmPhosphoSitePlus
Y321RRLRSyEDMIGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y588LRNLSyQVHREPhosphoSitePlus
T147KKVVKtVTTRTPhosphoSitePlus
T762SYDDStLPLIDHPRD
Y156SRQDVyGPQPQHPRD
S819RTLDRsGDLGDHPRD
Y335PSDQYyWAPLAPhosphoSitePlus
Y193GGPGPyVGQAGPhosphoSitePlus
Y174SVSNNyIQTLGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S251LASLDsLRKGGHPRD
S740EGWKKsDFQVNHPRD
T720IADLLtNEHERHPRD
S859NNASRsQSSHSPhosphoSitePlus; HPRD; RegPhos
S704VLINKsGNRSEHPRD
T201QAGTAtLPRNFPhosphoSitePlus
S300DYGMMsDYGTAPhosphoSitePlus; HPRD
T714IADLLtNEHERHPRD
T916GDHNRtLDRSGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T889GDHNRtLDRSGHPRD
Y280FHPEPyGLEDDPhosphoSitePlus; HPRD; RegPhos
S245QHERGsLASLDHPRD
S4VESTHPRD
S920RTLDRsGDLGDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S352LASLDsLRKGGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y898SLDNNySTPNEHPRD
S862HSYDDsTLPLIHPRD
S225GYPGGsDNYGSPhosphoSitePlus
S899GSNTKsLDNNYPhosphoSitePlus
T831EPLKGtTPLMQHPRD
S670VRIYIsLLKESArmPhosphoSitePlus
Y291QRSMGyDDLDYSRCHPRD; RegPhos
S893RTLDRsGDLGDHPRD
Y96HSHLLySTIPRSRCHPRD; RegPhos
S542VSSERsEARRKPhosphoSitePlus
S746EGWKKsDFQVNHPRD
Y248PSMEGyRAPSRPhosphoSitePlus
S813RTLDRsGDLGDHPRD
S171DASSVsNNYIQPhosphoSitePlus
T152TVTTRtVQPVAPhosphoSitePlus
S873DRNQKsDKKPDHPRD
S232NYGSLsRVTRIPhosphoSitePlus; HPRD; phosphoELM
S710VLINKsGNRSEHPRD
T863SYDDStLPLIDHPRD
T469RDMDLtEVITGArmPhosphoSitePlus
S847EGWKKsDFQVNPhosphoSitePlus; HPRD
Y127GGSDNyGSLSRHPRD
S129SDNYGsLSRVTHPRD
T932EPLKGtTPLMQphosphoELM
S805VLINKsGNRSEHPRD
S868HSYDDsTLPLIPhosphoSitePlus; HPRD
S651FPKRTsPARGYPhosphoSitePlus
T900DNNYStPNERGHPRD
Y112YPPDGySRHYEHPRD
S219RRRLRsYEDMIHPRD
Y116GYSRHyEDGYPHPRD
S853NNASRsQSSHSHPRD
S97SHLLYsTIPRMPhosphoSitePlus
S252GYRAPsRQDVYGSK3BHPRD; RegPhos
T209ARRTGtPSDPRHPRD
S230SDNYGsLSRVTPhosphoSitePlus; HPRD; phosphoELM
Y859QSSHSyDDSTLHPRD
Y228GGSDNyGSLSRSRCHPRD; RegPhos
S168RVGGSsVDLHRHPRD
Y228GGSDNyGSLSREGFRHPRD; RegPhos
Y228GGSDNyGSLSRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y257SRQDVyGPQPQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S214PPDGYsRHYEDPhosphoSitePlus
S587LLRNLsYQVHRPhosphoSitePlus
S790EEIQMsNMGSNHPRD
Y296YDDLDyGMMSDSRCHPRD; RegPhos
S574SLLKEsKTPAIHPRD
S143ERYRPsMEGYRHPRD

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S268PQVRVGGsSVDLHRFHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000433276Q607*BIOMARTBreast Cancer21930507, 21930502
ENSP00000434900Q338*BIOMARTBreast Cancer21930507, 21930502
ENSP00000436323Q601*BIOMARTBreast Cancer21930507, 21930502
ENSP00000351527Q655*BIOMARTBreast Cancer21930507, 21930502
ENSP00000435789Q601*BIOMARTBreast Cancer21930507, 21930502
ENSP00000436744Q607*BIOMARTBreast Cancer21930507, 21930502
ENSP00000354785P361TCOSMICBreast Cancer
ENSP00000413586Q655*BIOMARTBreast Cancer21930507, 21930502
ENSP00000409930Q554*BIOMARTBreast Cancer21930507, 21930502
ENSP00000437327Q554*BIOMARTBreast Cancer21930507, 21930502
ENSP00000432623Q332*BIOMARTBreast Cancer21930507, 21930502
ENSP00000409930M386VBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000432075Q554*BIOMARTBreast Cancer21930507, 21930502
ENSP00000437156Q554*BIOMARTBreast Cancer21930507, 21930502
ENSP00000434672Q338*BIOMARTBreast Cancer21930507, 21930502
ENSP00000433158Q332*BIOMARTBreast Cancer21930507, 21930502
ENSP00000351527M466VBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000403518Q560*BIOMARTBreast Cancer21930507, 21930502
ENSP00000436543Q655*BIOMARTBreast Cancer21930507, 21930502
ENSP00000354823Q655*BIOMARTBreast Cancer21930507, 21930502
ENSP00000433334Q601*BIOMARTBreast Cancer21930507, 21930502
ENSP00000435266Q560*BIOMARTBreast Cancer21930507, 21930502
ENSP00000354785L790RCOSMICRenal Cancer
ENSP00000382004Q661*BIOMARTBreast Cancer21930507, 21930502
ENSP00000435379Q601*BIOMARTBreast Cancer21930507, 21930502
ENSP00000354785S484*COSMICHead and Neck Cancer21798893
ENSP00000434017Q554*BIOMARTBreast Cancer21930507, 21930502
ENSP00000434949Q554*BIOMARTBreast Cancer21930507, 21930502
ENSP00000432243Q601*BIOMARTBreast Cancer21930507, 21930502
ENSP00000354785Q655*BIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000382004Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.3718646787
ENSP00000382004Gastric CancerMetastasiscell lineUp1.817022644
ENSP00000382004Gastric CancerMetastasiscell lineUp1.817022644
ENSP00000382004Breast CancerNormal vs. CancertissueDown20560667
ENSP00000382004Breast CancerNormal vs. CancertissueDown0.4320739354
ENSP00000382004Ovarian CancerTreatment (chemotherapy-sensitive vs. chemotherapy-resistant)tissueDown0.4519422301

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y228YPGGSDNyGSLSRVTcholangiocellular carcinoma21253578PhosphoSitePlus
Y257APSRQDVyGPQPQVRcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
SRC_HUMANCTND1_HUMANkinase -> substrateRegPhos
EGFR_HUMANCTND1_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANCTND1_HUMANkinase -> substrateRegPhos
GSK3B_HUMANCTND1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04670Leukocyte transendothelial migration
hsa04520Adherens junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolIMPcellular_component
GO:0005102receptor bindingIPImolecular_function
GO:0045216cell-cell junction organizationTASbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIMPbiological_process
GO:0016337cell-cell adhesionIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0045296cadherin bindingIPImolecular_function
GO:0005911cell-cell junctionIDAcellular_component
GO:0005488bindingIEAmolecular_function
GO:0005913cell-cell adherens junctionIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0001738morphogenesis of a polarized epitheliumIEAbiological_process
GO:0019903protein phosphatase bindingIEAmolecular_function
GO:0007155cell adhesionNASbiological_process
GO:0060690epithelial cell differentiation involved in salivaIEAbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0007435salivary gland morphogenesisIEAbiological_process
GO:0030027lamellipodiumIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0030216keratinocyte differentiationIEAbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0030496midbodyIDAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0034332adherens junction organizationTASbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0034329cell junction assemblyTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process


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