Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NMDE2_HUMAN
Description:glutamate receptor, ionotropic, N-methyl D-aspartate 2B [Source:HGNC Symbol;Acc:4586]
Location:chr12 p13.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1474SNGHVyEKLSSNMDAR2_CPhosphoSitePlus
Y1474SNGHVyEKLSSRegPhos
S930IRRESsVYDISRegPhos
Y1109EIELAyRRRPPRegPhos
T1306QHSYDtFVDLQNMDAR2_CPhosphoSitePlus
S1303LRRQHsYDTFVPKCbRegPhos
Y762FASTGyGIAIQSBP_bac_3; Lig_chanPhosphoSitePlus
Y1474SNGHVyEKLSSSRCHPRD; RegPhos
S1303LRRQHsYDTFVCAMK2BHPRD
S1303LRRQHsYDTFVRegPhos
S1303LRRQHsYDTFVNMDAR2_CPhosphoSitePlus
S1323APRSVsLKDKGPKCbRegPhos
S1323APRSVsLKDKGPKCaRegPhos
S1191KHGVVsGVPAPNMDAR2_CPhosphoSitePlus
S720DDALLsLKTGKSBP_bac_3; Lig_chanPhosphoSitePlus
Y1252KAGNLyDISEDFYNHPRD; RegPhos
S1469AFNGSsNGHVYNMDAR2_CPhosphoSitePlus
S1323APRSVsLKDKGPRKCAHPRD
S1323APRSVsLKDKGPRKCBHPRD
S1323APRSVsLKDKGPRKCGHPRD
S1303LRRQHsYDTFVPRKCBHPRD
S1303LRRQHsYDTFVPRKCAHPRD
S1303LRRQHsYDTFVPRKCGHPRD
S1303LRRQHsYDTFVPKC_alphaphosphoELM
T475KSVKFtYDLYLSBP_bac_3PhosphoSitePlus
S383KWKDKsLQMKYCAMK2BHPRD
S383KWKDKsLQMKYCAMK2AHPRD
Y1336MDGSPyAHMFEFYNHPRD; RegPhos
Y1304RRQHSyDTFVDNMDAR2_CPhosphoSitePlus
S770AIQKDsGWKRQSBP_bac_3; Lig_chanPhosphoSitePlus
Y949SDCKSyNNPPCRegPhos
Y1039QLSDLyGKFSFFYNHPRD; RegPhos
Y239KEEATyIFEVAANF_receptorPhosphoSitePlus
S1323APRSVsLKDKGNMDAR2_CPhosphoSitePlus
T493KKINGtWNGMISBP_bac_3PhosphoSitePlus
Y1155DLTDIyKERSDRegPhos
Y932RESSVyDISEHFYNHPRD; RegPhos
S1323APRSVsLKDKGPKCa(PKC alphaRegPhos
S1168KRDSVsGGGPCNMDAR2_CPhosphoSitePlus
S1303LRRQHsYDTFVCAMK2AHPRD
Y1070THTVTyGNIEGRegPhos
S1323APRSVsLKDKGPKCgRegPhos
Y962NLFSDyISEVERegPhos
Y1109EIELAyRRRPPFYNHPRD; RegPhos
T760KVFAStGYGIASBP_bac_3; Lig_chanPhosphoSitePlus
S1303LRRQHsYDTFVPKCa(PKC alphaRegPhos
Y705AEMHAyMGKFNSBP_bac_3; Lig_chanPhosphoSitePlus
Y932RESSVyDISEHRegPhos
Y1049FKSDRySGHDDRegPhos
S917SGVNGsPQSALRegPhos
T514AVGSLtINEERSBP_bac_3PhosphoSitePlus
Y1252KAGNLyDISEDRegPhos
S1166DFKRDsVSGGGRegPhos
S759GKVFAsTGYGISBP_bac_3; Lig_chanPhosphoSitePlus
Y1304RRQHSyDTFVDRegPhos
S865MVFSIsRGIYSNMDAR2_CPhosphoSitePlus
Y1474SNGHVyEKLSSFYNHPRD; RegPhos
S1303LRRQHsYDTFVCaMK2bRegPhos
Y1070THTVTyGNIEGFYNHPRD; RegPhos
S1303LRRQHsYDTFVPKCaRegPhos
S1303LRRQHsYDTFVPKCgRegPhos
Y1039QLSDLyGKFSFRegPhos
S1323APRSVsLKDKGPKC_alphaphosphoELM
Y1039QLSDLyGKFSFNMDAR2_CPhosphoSitePlus
T1065VSDIStHTVTYRegPhos
S1303LRRQHsYDTFVCaMK2aRegPhos
S383KWKDKsLQMKYCaMK2aRegPhos
S383KWKDKsLQMKYCaMK2bRegPhos
S1061IRSDVsDISTHRegPhos
S1166DFKRDsVSGGGNMDAR2_CPhosphoSitePlus
S1043KFSFKSysPTM 2.0

Dephosphorylation site
NMDE2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000279593E1106KCOSMICCentral Nervous System Neoplasms18772396
ENSP00000279593E1243QCOSMICHead and Neck Cancer21798893
ENSP00000279593G763VCOSMICOvarian Cancer21720365
ENSP00000279593E47KCOSMICSkin Cancer21984974
ENSP00000279593Q1291HCOSMICHead and Neck Cancer21798893
ENSP00000279593G1449ECOSMICMelanoma
ENSP00000279593A1276VCOSMICCentral Nervous System Neoplasms18772396
ENSP00000279593I190VBIOMARTBreast Cancer21930507, 21930502
ENSP00000279593F1137LCOSMICHead and Neck Cancer21798893
ENSP00000279593R519QCOSMICOvarian Cancer21720365
ENSP00000279593R92LCOSMICLung Cancer
ENSP00000279593G995RCOSMICHead and Neck Cancer21798893

Differential expressed protein
NMDE2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NMDE2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KCC2B_HUMANNMDE2_HUMANkinase -> substrateHPRD
KPCB_HUMANNMDE2_HUMANkinase -> substrateHPRD
SRC_HUMANNMDE2_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANNMDE2_HUMANkinase -> substrateRegPhos
KPCA_HUMANNMDE2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
FYN_HUMANNMDE2_HUMANkinase -> substrateRegPhos
KPCG_HUMANNMDE2_HUMANkinase -> substrateHPRD
KCC2A_HUMANNMDE2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04724Glutamatergic synapse
hsa05033Nicotine addiction
hsa05030Cocaine addiction
hsa04728Dopaminergic synapse
hsa05322Systemic lupus erythematosus
hsa05034Alcoholism
hsa05016Huntington's disease
hsa05010Alzheimer's disease
hsa04720Long-term potentiation
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05031Amphetamine addiction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007215glutamate receptor signaling pathwayTASbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0004972N-methyl-D-aspartate selective glutamate receptor IEAmolecular_function
GO:0050966detection of mechanical stimulus involved in sensoIEAbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0014069postsynaptic densityIEAcellular_component
GO:0030288outer membrane-bounded periplasmic spaceIEAcellular_component
GO:0007612learningIEAbiological_process
GO:0016594glycine bindingIDAmolecular_function
GO:0006810transportTASbiological_process
GO:0070588calcium ion transmembrane transportIEAbiological_process
GO:0045471response to ethanolIDAbiological_process
GO:0005261cation channel activityIEAmolecular_function
GO:0043005neuron projectionISScellular_component
GO:0060078regulation of postsynaptic membrane potentialIEAbiological_process
GO:0007423sensory organ developmentIEAbiological_process
GO:0048167regulation of synaptic plasticityIEAbiological_process
GO:0001964startle responseIEAbiological_process
GO:0017146N-methyl-D-aspartate selective glutamate receptor IEAcellular_component
GO:0060079regulation of excitatory postsynaptic membrane potIEAbiological_process
GO:0001662behavioral fear responseIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005234extracellular-glutamate-gated ion channel activityIEAmolecular_function
GO:0008270zinc ion bindingISSmolecular_function
GO:0045211postsynaptic membraneIEAcellular_component
GO:0006816calcium ion transportIEAbiological_process
GO:0009790embryo developmentIEAbiological_process
GO:0007268synaptic transmissionIEAbiological_process
GO:0017146N-methyl-D-aspartate selective glutamate receptor IDAcellular_component
GO:0030054cell junctionIEAcellular_component
GO:0045202synapseIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0006812cation transportIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0007611learning or memoryTASbiological_process
GO:0007613memoryIEAbiological_process
GO:0004970ionotropic glutamate receptor activityIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0008021synaptic vesicleIEAcellular_component
GO:0001967suckling behaviorIEAbiological_process
GO:0005262calcium channel activityIEAmolecular_function
GO:0042596fear responseIEAbiological_process
GO:0048266behavioral response to painIEAbiological_process
GO:0009986cell surfaceISScellular_component
GO:0005215transporter activityIEAmolecular_function


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