UniProt/SwissProt ID: | RHG35_HUMAN |
Description: | Rho GTPase activating protein 35 [Source:HGNC Symbol;Acc:4591] |
Location: | chr19 q13.32 |
Node attribute: | PPI(source); substrate; TF |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
S1057 | TKGDLsYLDQG | PhosphoSitePlus | |
T1173 | FASYRtSFSVG | PhosphoSitePlus; HPRD; phosphoELM | |
Y1104 | NEEENiYSVPH | HPRD | |
S1491 | QPLLPsQLQAE | HPRD | |
S1153 | KVSIVsKPVLY | PhosphoSitePlus | |
T771 | NLVSStASIKD | PhosphoSitePlus | |
S1179 | SFSVGsDDELG | PhosphoSitePlus; HPRD; phosphoELM | |
S667 | LCLYNsKESLS | PhosphoSitePlus | |
S1150 | RGRKVsIVSKP | PhosphoSitePlus; HPRD; phosphoELM | |
S1085 | DGFDPsDYAEP | PhosphoSitePlus | |
T1226 | SLRRNtKKPKP | PhosphoSitePlus | |
Y1105 | EEENIySVPHD | SRC | HPRD; phosphoELM |
T1140 | DSEMDtSSLER | PhosphoSitePlus; HPRD; phosphoELM | |
Y1087 | FDPSDyAEPMD | PhosphoSitePlus; HPRD; phosphoELM | |
S1221 | RNILRsLRRNT | PhosphoSitePlus | |
S1134 | GSGNGsDSEMD | PhosphoSitePlus; HPRD; phosphoELM | |
T963 | AEACStTEEVF | PhosphoSitePlus; HPRD; phosphoELM | |
S575 | IEHLIsSRFIR | PhosphoSitePlus | |
S1074 | KSVSSsPWLPQ | PhosphoSitePlus; HPRD; phosphoELM | |
S1072 | QRKSVsSSPWL | PhosphoSitePlus; HPRD; phosphoELM | |
S773 | VSSTAsIKDLA | PhosphoSitePlus | |
S1106 | EENIYsVPHDS | PhosphoSitePlus | |
T1480 | QSPPPtPQSPM | HPRD | |
S1141 | SEMDTsSLERG | HPRD; phosphoELM | |
S591 | QKNSLsDPNID | HPRD | |
Y1207 | NAVIPyETDED | PhosphoSitePlus | |
S46 | RFVRPsADEFH | PhosphoSitePlus | |
S1111 | SVPHDsTQGKI | PhosphoSitePlus | |
S1001 | FREDTsLPSLS | PhosphoSitePlus | |
S589 | RNQKNsLSDPN | PhosphoSitePlus; HPRD; phosphoELM | |
S1236 | PKPRPsITKAT | PhosphoSitePlus | |
S980 | SPLCNsNLQDS | HPRD; phosphoELM | |
S1476 | PSPPQsPPPTP | HPRD | |
S985 | SNLQDsEEDIE | PhosphoSitePlus; HPRD; phosphoELM | |
S1174 | ASYRTsFSVGS | PhosphoSitePlus | |
S970 | EEVFNsPRAGS | PhosphoSitePlus; HPRD; phosphoELM | |
S1073 | RKSVSsSPWLP | HPRD; phosphoELM | |
Y209 | EGVERyIRDAH | Ras | PhosphoSitePlus |
S1195 | EEDQAsQGYKG | PhosphoSitePlus; HPRD; phosphoELM | |
S1130 | AQSNGsGNGSD | PhosphoSitePlus | |
S182 | QLKFVsNLYNQ | HPRD | |
S576 | EHLISsRFIRP | PhosphoSitePlus | |
S1127 | INKAQsNGSGN | PhosphoSitePlus; HPRD; phosphoELM | |
S1070 | DGQRKsVSSSP | PhosphoSitePlus; HPRD; phosphoELM | |
S975 | SPRAGsPLCNS | PhosphoSitePlus; HPRD; phosphoELM | |
Y855 | RLVHGyIVFYS | PhosphoSitePlus | |
S1450 | PGARPsSPSAV | HPRD | |
S1142 | EMDTSsLERGR | PhosphoSitePlus | |
T685 | KSREStLGRRD | HPRD; phosphoELM | |
Y1198 | QASQGyKGDNA | PhosphoSitePlus | |
T1112 | VPHDStQGKII | PhosphoSitePlus | |
Y1105 | EEENIySVPHD | PhosphoSitePlus; phosphoELM | |
Y1158 | SKPVLyRTRCT | HPRD | |
Dephosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
Y1105 | RNEEENIySVPHDST | PTPRZ1 | HPRD |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000385720 | W452* | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 |
ENSP00000385720 | L671Q | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000385720 | S752I | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000385720 | E1102Q | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000385720 | I210V | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
ENSP00000385720 | *1500W | COSMIC | Hepatocellular Carcinoma | |
ENSP00000385720 | Q586* | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000385720 | S985* | TCGA | Ovarian Cancer | 21720365, 18772890 |
Differential expressed protein |
RHG35_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
RHG35_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
ZAGL2_HUMAN | RHG35_HUMAN | kinase -> substrate | RegPhos |
SRC_HUMAN | RHG35_HUMAN | kinase -> substrate | KEGG; HPRD; RegPhos |
PTPRZ_HUMAN | RHG35_HUMAN | phosphatase -> substrate | HPRD |
RHG35_HUMAN | RHOA_HUMAN | other | KEGG |
RHG35_HUMAN | GCR_HUMAN | TF -> target gene | TRANSFAC |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa04670 | Leukocyte transendothelial migration |
hsa04810 | Regulation of actin cytoskeleton |
hsa04510 | Focal adhesion |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0043116 | negative regulation of vascular permeability | IEA | biological_process |
GO:0007411 | axon guidance | TAS | biological_process |
GO:0015629 | actin cytoskeleton | IEA | cellular_component |
GO:0005737 | cytoplasm | IEA | cellular_component |
GO:0005634 | nucleus | IC | cellular_component |
GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |
GO:0032321 | positive regulation of Rho GTPase activity | TAS | biological_process |
GO:0043010 | camera-type eye development | IEA | biological_process |
GO:0051056 | regulation of small GTPase mediated signal transdu | TAS | biological_process |
GO:0003714 | transcription corepressor activity | TAS | molecular_function |
GO:0005525 | GTP binding | IEA | molecular_function |
GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
GO:0003677 | DNA binding | IEA | molecular_function |
GO:0030900 | forebrain development | IEA | biological_process |
GO:0001843 | neural tube closure | IEA | biological_process |
GO:0008360 | regulation of cell shape | IEA | biological_process |
GO:0005100 | Rho GTPase activator activity | TAS | molecular_function |
GO:0005829 | cytosol | TAS | cellular_component |
GO:0007264 | small GTPase mediated signal transduction | TAS | biological_process |
GO:0007165 | signal transduction | IEA | biological_process |
GO:0005622 | intracellular | IEA | cellular_component |