Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTN6_HUMAN
Description:protein tyrosine phosphatase, non-receptor type 6 [Source:HGNC Symbol;Acc:9658]
Location:chr12 p13.31
Node attribute:phosphotase; substrate; kinase; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y111TSERWyHGHMSSH2PhosphoSitePlus
S534QKGQEsEYGNIPhosphoSitePlus
S26RGVHGsFLARPSH2PhosphoSitePlus
S250WEEFEsLQKQEPhosphoSitePlus
Y536GQESEyGNITYAblphosphoELM
Y364NKCVPyWPEVGY_phosphatasePhosphoSitePlus
Y543YGNITyPPAMKHPRD
S186LETFDsLTDLVSH2PhosphoSitePlus
Y536GQESEyGNITYPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S378AYGPYsVTNCGY_phosphatasePhosphoSitePlus
Y536GQESEyGNITYLckphosphoELM; RegPhos
S591EKSKGsLKPRKCAHPRD
Y564HKEDVyENLHTSRCphosphoELM
Y564HKEDVyENLHTPhosphoSitePlus; phosphoELM
T188TFDSLtDLVEHSH2PhosphoSitePlus
Y63NSGDFyDLYGGHPRD
Y541YGNITyPPAMKPhosphoSitePlus; HPRD
T394EYKLRtLQVSPY_phosphatasePhosphoSitePlus
S528LEVLQsQKGQEPhosphoSitePlus
S398RTLQVsPLDNGY_phosphatasePhosphoSitePlus
S559ASRTSsKHKEDHPRD
S588ADKEKsKGSLKPhosphoSitePlus
S299SNIPGsDYINAY_phosphatasePhosphoSitePlus
T540EYGNItYPPAMPhosphoSitePlus
S582VKKQRsADKEKPhosphoSitePlus
Y509QYKFIyVAIAQY_phosphatasePhosphoSitePlus
Y564HKEDVyENLHTLYNHPRD; RegPhos
T555AKASRtSSKHKPhosphoSitePlus
Y64DFYDLyGGEKFHPRD
Y276KGKNRyKNILPY_phosphatasePhosphoSitePlus
Y536GQESEyGNITYLCKHPRD; RegPhos
Y564HKEDVyENLHTABL1HPRD; RegPhos
Y564HKEDVyENLHTSrcRegPhos
Y306YINANyIKNQLY_phosphatasePhosphoSitePlus
Y536GQESEyGNITYSrcRegPhos
S591EKSKGsLKPKC_alphaphosphoELM
S553AHAKAsRTSSKPhosphoSitePlus
Y61NSGDFyDLYGGSH2PhosphoSitePlus
Y536GQESEyGNITYSRCphosphoELM
Y377RAYGPySVTNCRegPhos
Y566HKEDVyENLHTLCKHPRD
Y374GMQRAyGPYSVY_phosphatasePhosphoSitePlus
S496VRAQRsGMVQTY_phosphatasePhosphoSitePlus
Y61NSGDFyDLYGGHPRD
Y538GQESEyGNITYLCKHPRD
Y98IIHLKyPLNCSPhosphoSitePlus
S591EKSKGsLKRK_PhosphoSitePlus
Y536GQESEyGNITYABL1HPRD; RegPhos
Y301IPGSDyINANYY_phosphatasePhosphoSitePlus
Y64DFYDLyGGEKFSH2PhosphoSitePlus
Y214LRQPYyATRVNPhosphoSitePlus
Y509QYKFIyVAIAQRegPhos
Y377RAYGPySVTNCY_phosphatasePhosphoSitePlus
Y564HKEDVyENLHTLckphosphoELM; RegPhos
S557ASRTSsKHKEDPhosphoSitePlus; HPRD
Y564HKEDVyENLHTLCKHPRD; RegPhos
Y390HDTTEyKLRTLY_phosphatasePhosphoSitePlus
S591EKSKGsLKRKPKCa(PKC alphaRegPhos
Y66DFYDLyGGEKFHPRD
Y213YLRQPyYATRVPhosphoSitePlus
Y564HKEDVyENLHTAblphosphoELM
Y538GQESEyGNITYINSRHPRD
Y176CEGGRyTVGGLSH2PhosphoSitePlus
S556KASRTsSKHKEPhosphoSitePlus
Y536GQESEyGNITYINSRHPRD; RegPhos
S10FHRDLsGLDAESH2PhosphoSitePlus
S591EKSKGsLKRKPKCaRegPhos

Dephosphorylation site
PTN6_HUMAN do not have dephosphorylation site.

Mutation site
PTN6_HUMAN do not have mutation site.

Differential expressed protein
PTN6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PTN6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
INSR_HUMANPTN6_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANPTN6_HUMANkinase -> substrateRegPhos
LCK_HUMANPTN6_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PTN6_HUMANLCP2_HUMANkinase -> substrateNetPath
LYN_HUMANPTN6_HUMANkinase -> substrateHPRD; RegPhos
KPCA_HUMANPTN6_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANPTN6_HUMANkinase -> substrateRegPhos
PTN6_HUMANCD79A_HUMANphosphatase -> substrateNetPath
PTN6_HUMANJAK1_HUMANphosphatase -> substrateNetPath
PTN6_HUMANGAB2_HUMANphosphatase -> substrateHPRD
PTN6_HUMANCD3Z_HUMANphosphatase -> substrateKEGG; NetPath
PTN6_HUMANESR1_HUMANphosphatase -> substrateHPRD
PTN6_HUMANKSYK_HUMANphosphatase -> substrateKEGG
PTN6_HUMANCD33_HUMANphosphatase -> substrateHPRD
PTN6_HUMANLYN_HUMANphosphatase -> substrateHPRD
PTN6_HUMANHXA10_HUMANphosphatase -> substrateHPRD
PTN6_HUMANSRC_HUMANphosphatase -> substrateHPRD
PTN6_HUMANBLNK_HUMANphosphatase -> substrateNetPath
PTN6_HUMANIL3RB_HUMANphosphatase -> substrateHPRD
PTN6_HUMANJAK3_HUMANphosphatase -> substrateNetPath
PTN6_HUMANZAP70_HUMANphosphatase -> substrateKEGG
PTN6_HUMANEGFR_HUMANphosphatase -> substrateHPRD
PTN6_HUMANLCK_HUMANphosphatase -> substrateHPRD
PTN6_HUMANCD72_HUMANphosphatase -> substrateNetPath
PTN6_HUMANSHPS1_HUMANphosphatase -> substrateHPRD
PTN6_HUMANKIT_HUMANphosphatase -> substrateHPRD; NetPath
PTN6_HUMANIL2RB_HUMANphosphatase -> substrateNetPath
PTN6_HUMANPECA1_HUMANphosphatase -> substrateHPRD
PTN6_HUMANCD79B_HUMANphosphatase -> substrateNetPath
PTN6_HUMANBTK_HUMANphosphatase -> substrateKEGG
PTN6_HUMANCD22_HUMANphosphatase -> substrateHPRD
PTN6_HUMANI22R2_HUMANotherKEGG
PTN6_HUMANJAK1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04520Adherens junction
hsa04662B cell receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa05140Leishmaniasis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0070372regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0043409negative regulation of MAPK cascadeIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0042105alpha-beta T cell receptor complexIEAcellular_component
GO:0050853B cell receptor signaling pathwayIEAbiological_process
GO:0005001transmembrane receptor protein tyrosine phosphatasIDAmolecular_function
GO:0004725protein tyrosine phosphatase activityIEAmolecular_function
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0035335peptidyl-tyrosine dephosphorylationTASbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaIMPbiological_process
GO:0008285negative regulation of cell proliferationNASbiological_process
GO:0050732negative regulation of peptidyl-tyrosine phosphoryIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0008283cell proliferationIDAbiological_process
GO:0016791phosphatase activityIEAmolecular_function
GO:0004725protein tyrosine phosphatase activityTASmolecular_function
GO:0016020membraneTAScellular_component
GO:0043407negative regulation of MAP kinase activityIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0060397JAK-STAT cascade involved in growth hormone signalTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0050860negative regulation of T cell receptor signaling pIEAbiological_process
GO:0060334regulation of interferon-gamma-mediated signaling TASbiological_process
GO:0042267natural killer cell mediated cytotoxicityIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030154cell differentiationIDAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0042169SH2 domain bindingIEAmolecular_function
GO:0016311dephosphorylationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0042130negative regulation of T cell proliferationIEAbiological_process
GO:0002924negative regulation of humoral immune response medIEAbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0060337type I interferon-mediated signaling pathwayTASbiological_process
GO:2000045regulation of G1/S transition of mitotic cell cyclIMPbiological_process
GO:0006470protein dephosphorylationIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0006470protein dephosphorylationIDAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0045577regulation of B cell differentiationIEAbiological_process
GO:0060338regulation of type I interferon-mediated signalingTASbiological_process
GO:0001784phosphotyrosine bindingIEAmolecular_function
GO:0035335peptidyl-tyrosine dephosphorylationIEAbiological_process
GO:0050732negative regulation of peptidyl-tyrosine phosphoryIMPbiological_process