Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:VINC_HUMAN
Description:vinculin [Source:HGNC Symbol;Acc:12665]
Location:chr10 q22.2
Node attribute:PPI(source); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S443ISALTsKLADLHPRD
T324REILGtCKMLGRegPhos
Y107VPARDyLIDGSVinculinPhosphoSitePlus
Y692GNQAAyEHFETVinculinPhosphoSitePlus
T1055TDAGFtLRWVRHPRD
S664EGIQAsVKTARVinculinPhosphoSitePlus
T508WIDNPtVDDRGphosphoELM; RegPhos
Y822FLDSGyRILGAVinculinPhosphoSitePlus; SysPTM
Y1065RKTPWSRCHPRD
S579SQLQDsLKDLKHPRD
S380EAMTNsKQSIAHPRD
S290RDPSAsPGDAGHPRD; RegPhos; SysPTM
S434DDILRsLGEISVinculinPhosphoSitePlus
S1033QNLMQsVKETVPRKCAHPRD
T442EISALtSKLADHPRD
Y100LQSDPySVPARSRCHPRD; RegPhos
S1101QNLMQsVKETVPRKCAHPRD
S721AIDTKsLLDASVinculinPhosphoSitePlus; SysPTM
Y1133RKTPWyQ____VinculinPhosphoSitePlus
S1101QNLMQsVKETVPKCa(PKC alphaRegPhos
T1123TDAGFtLRWVRHPRD
Y1133RKTPWSRCHPRD
Y822FLDSGyRILGAHPRD; phosphoELM; RegPhos; SysPTM
T604FSDTTtPIKLLHPRD; RegPhos
S290RDPSAsPGDAGVinculinPhosphoSitePlus; SysPTM
S1113EAEAAsIKIRTPKC_alphaphosphoELM
S721AIDTKsLLDASHPRD; RegPhos; SysPTM
S774REVENsEDPKFRegPhos
T604FSDTTtPIKLLVinculinPhosphoSitePlus
Y100LQSDPySVPARVinculinPhosphoSitePlus
T697YEHFEtMKNQWVinculinPhosphoSitePlus
S346RGQGSsPVAMQVinculinPhosphoSitePlus
S1113EAEAAsIKIRTPKCaRegPhos
S112YLIDGsRGILSVinculinPhosphoSitePlus
Y692GNQAAyEHFETHPRD; phosphoELM
S1113EAEAAsIKIRTPKCa(PKC alphaRegPhos
S1101QNLMQsVKETVPKCaRegPhos
Y1133RKTPWyQSRCRegPhos
S579SQLQDsLKDLKVinculinPhosphoSitePlus
Y1133RKTPWyQRegPhos
S434DDILRsLGEISHPRD
S101QSDPYsVPARDVinculinPhosphoSitePlus
S275LASIDsKLNQAVinculinPhosphoSitePlus
S1101QNLMQsVKETVPKC_alphaphosphoELM
S288WLRDPsASPGDVinculinPhosphoSitePlus
S809VAGNIsDPGLQHPRD
T1123TDAGFtLRWVRVinculinPhosphoSitePlus
S357KAQQVsQGLDVVinculinPhosphoSitePlus
S1045EAEAAsIKIRTPRKCAHPRD
S816PGLQKsFLDSGVinculinPhosphoSitePlus
S566RGEGEsPQARAVinculinPhosphoSitePlus
S346RGQGSsPVAMQHPRD
Y537VMMGPyRQDLLRegPhos
S1113EAEAAsIKIRTPRKCAHPRD
S288WLRDPsASPGDHPRD
Y1133RKTPWphosphoELM
T754LVAGAtSIARRVinculinPhosphoSitePlus
T508WIDNPtVDDRGVinculinPhosphoSitePlus
S820KSFLDsGYRILVinculinPhosphoSitePlus
S809VAGNIsDPGLQVinculinPhosphoSitePlus

Dephosphorylation site
VINC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000211998E623DCOSMICOvarian Cancer21720365
ENSP00000361841E623DTCGAOvarian Cancer21720365, 18772890
ENSP00000211998P457SCOSMICCentral Nervous System Neoplasms18772396
ENSP00000211998P617SCOSMICOvarian Cancer21720365
ENSP00000361841P457SBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000361841P617STCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000211998Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.2918646787
ENSP00000211998Pancreatic CancerNormal vs. CancertissueUp4.316215274
ENSP00000211998Gastric CancerMetastasiscell lineDown0.5417022644
ENSP00000211998Prostate CancerTreatment (none vs. bicalutamide treatment)cell lineUp1.417152098
ENSP00000211998Prostate CancerTreatment (none vs. bicalutamide treatment)cell lineUp2.217152098
ENSP00000211998Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000211998colorectal cancerNormal vs. CancertissueDown0.6614997500
ENSP00000211998Prostate CancerMetastasistissueDown0.4618553995
ENSP00000211998Esophageal CancerNormal vs. CancertissueDown0.419142970
ENSP00000211998Breast CancerNormal vs. CancertissueUp18257521
ENSP00000211998Hepatocellular CarcinomaMetastasiscell lineUp1.519016532
ENSP00000211998Gastric CancerMetastasiscell lineDown0.5417022644
ENSP00000211998Breast CancerNormal vs. Cancercell lineUp1.320543960
ENSP00000211998Breast CancerNormal vs. CancertissueDown0.4520739354
ENSP00000211998Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueUp2.116807943
ENSP00000211998NonmelanomaNormal vs. Cancercell lineDown0.6819243805
ENSP00000211998Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.519714814
ENSP00000211998Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.5619714814
ENSP00000211998Gastric CancerTreatment (none vs. drug-resistant)cell lineUp1.520625496

Hyperphosphorylation site
VINC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANVINC_HUMANkinase -> substrateRegPhos
KPCA_HUMANVINC_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
SRC_HUMANVINC_HUMANkinase -> substrateRegPhos
VINC_HUMANFYV1_HUMANotherKEGG
PI51C_HUMANVINC_HUMANotherKEGG
FYV1_HUMANVINC_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04520Adherens junction
hsa05131Shigellosis
hsa04510Focal adhesion
hsa05146Amoebiasis
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05100Bacterial invasion of epithelial cells

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0030336negative regulation of cell migrationTASbiological_process
GO:0030032lamellipodium assemblyISSbiological_process
GO:0005912adherens junctionISScellular_component
GO:0005198structural molecule activityIEAmolecular_function
GO:0034333adherens junction assemblyIMPbiological_process
GO:0043034costamereISScellular_component
GO:0005911cell-cell junctionIEAcellular_component
GO:0045294alpha-catenin bindingIPImolecular_function
GO:0034394protein localization to cell surfaceIMPbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0030334regulation of cell migrationIEAbiological_process
GO:0006928cellular component movementTASbiological_process
GO:0008013beta-catenin bindingISSmolecular_function
GO:0005925focal adhesionISScellular_component
GO:0007155cell adhesionIEAbiological_process
GO:0003779actin bindingIDAmolecular_function
GO:0006936muscle contractionTASbiological_process
GO:0015629actin cytoskeletonIEAcellular_component
GO:0005916fascia adherensIEAcellular_component
GO:0007160cell-matrix adhesionTASbiological_process
GO:0030055cell-substrate junctionNAScellular_component
GO:0017048Rho GTPase bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0043234protein complexIDAcellular_component
GO:0030168platelet activationTASbiological_process
GO:0005913cell-cell adherens junctionIDAcellular_component
GO:0043297apical junction assemblyIMPbiological_process
GO:0007155cell adhesionTASbiological_process
GO:0090136epithelial cell-cell adhesionIMPbiological_process
GO:0042383sarcolemmaIEAcellular_component
GO:0005576extracellular regionTAScellular_component
GO:0045296cadherin bindingISSmolecular_function
GO:0002576platelet degranulationTASbiological_process
GO:0043034costamereIEAcellular_component
GO:0014704intercalated discIEAcellular_component
GO:0005912adherens junctionIEAcellular_component
GO:0005856cytoskeletonTAScellular_component
GO:0005925focal adhesionIEAcellular_component
GO:0030018Z discIEAcellular_component
GO:0002162dystroglycan bindingIPImolecular_function
GO:0030032lamellipodium assemblyIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0002009morphogenesis of an epitheliumIMPbiological_process
GO:0005911cell-cell junctionISScellular_component
GO:0005515protein bindingIEAmolecular_function