Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SHIP2_HUMAN
Description:inositol polyphosphate phosphatase-like 1 [Source:HGNC Symbol;Acc:6080]
Location:chr11 q13.4
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1131MAKTLsEVDYAPhosphoSitePlus
S1003PPEPPsPARAPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T1129LQMAKtLSEVDPhosphoSitePlus
S1039VGEGSsSDEESHPRD
S182GLSTVsHDYLKPhosphoSitePlus
S1061PPLPDsAIFLPHPRD
S980PPPKNsFNNPAPhosphoSitePlus
Y987NNPAYyVLEGVPhosphoSitePlus
Y987NNPAYyVLEGVSRCHPRD; phosphoELM
S833MDGYEsYGECVPhosphoSitePlus
Y987NNPAYyVLEGVSrcRegPhos
Y661SFPPTyRYERGExo_endo_phosPhosphoSitePlus
T958REEPLtPRLKPPhosphoSitePlus; RegPhos
S827LLTVKsMDGYEPhosphoSitePlus
Y986FNNPAyYVLEGPhosphoSitePlus; phosphoELM; SysPTM
T167APETPtAPAAEPhosphoSitePlus; HPRD; phosphoELM
S240VFDQQsSPMVTHPRD
S1202GEAGMsAWLRASAM_2PhosphoSitePlus
S291LQDMSsTAPPAHPRD
S189DYLKGsYGLDLPhosphoSitePlus
S1104LPPGPsPASTFPhosphoSitePlus
Y985SFNNPaYYVLEHPRD
S1038RVGEGsSSDEEHPRD
S158PTGPSsPLPAPPhosphoSitePlus; HPRD; phosphoELM
Y986FNNPAyYVLEGSRCHPRD; phosphoELM; RegPhos; SysPTM
Y671GSRDTyAWHKQExo_endo_phosPhosphoSitePlus
Y886TRERLyEWISIPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y1213IGLERyEEGLVSAM_2PhosphoSitePlus
Y1134TLSEVdYAPAGHPRD
Y885GTRERlYEWISHPRD
S1068IFLPPsLDPLPHPRD
S49FLVRDsESVAGSH2PhosphoSitePlus
S132DDRDAsDGEDEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S290ALQDMsSTAPPHPRD
S1167YGRPLsFPPPRPhosphoSitePlus
S1011RAPVPsATKNKPhosphoSitePlus
S890LYEWIsIDKDEPhosphoSitePlus; HPRD
Y663PPTYRyERGSRExo_endo_phosPhosphoSitePlus
Y986FNNPAyYVLEGSrcRegPhos; SysPTM
T165LPAPEtPTAPAPhosphoSitePlus; HPRD; phosphoELM
Y1162GLPSDyGRPLSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S241FDQQSsPMVTRPhosphoSitePlus; HPRD; phosphoELM
Y622QEILNyISRKEExo_endo_phosPhosphoSitePlus
Y922RKPAFtEASCPRegPhos
T1013PVPSAtKNKVAPhosphoSitePlus
Y190YLKGSyGLDLEPhosphoSitePlus
Y62ALCVLyQKHVHSH2PhosphoSitePlus
S1257DTLQLsK____SAM_2PhosphoSitePlus
S1160PRGLPsDYGRPPhosphoSitePlus
T1253RLLLDtLQLSKSAM_2PhosphoSitePlus
Y671GSRDTyAWHKQHPRD; phosphoELM; RegPhos
Y1135LSEVDyAPAGPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T881TERLGtRERLYPhosphoSitePlus
Y831KSMDGyESYGEPhosphoSitePlus

Dephosphorylation site
SHIP2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000298229S84LCOSMICSkin Cancer21984974
ENSP00000446360*1017KCOSMICMelanoma21499247
ENSP00000298229E1184QCOSMICBreast Cancer20668451
ENSP00000444619*1017KCOSMICMelanoma21499247
ENSP00000298229G378DCOSMICMelanoma
ENSP00000298229L207FCOSMICSkin Cancer21984974
ENSP00000298229G864DCOSMICMelanoma
ENSP00000298229R342QTCGA, COSMICOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000298229Gastric CancerMetastasiscell lineDown0.4117022644
ENSP00000298229Gastric CancerMetastasiscell lineDown0.4117022644

Hyperphosphorylation site
SHIP2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SRC_HUMANSHIP2_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANSHIP2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04070Phosphatidylinositol signaling system
hsa04666Fc gamma R-mediated phagocytosis
hsa04910Insulin signaling pathway
hsa00562Inositol phosphate metabolism
hsa04662B cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043407negative regulation of MAP kinase activityIEAbiological_process
GO:0043569negative regulation of insulin-like growth factor IEAbiological_process
GO:0046854phosphatidylinositol phosphorylationIEAbiological_process
GO:0010642negative regulation of platelet-derived growth facIEAbiological_process
GO:0007420brain developmentIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0032957inositol trisphosphate metabolic processIEAbiological_process
GO:0046627negative regulation of insulin receptor signaling IEAbiological_process
GO:0007015actin filament organizationIMPbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0006644phospholipid metabolic processTASbiological_process
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0042169SH2 domain bindingIPImolecular_function
GO:0010977negative regulation of neuron projection developmeIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0032868response to insulin stimulusIEAbiological_process
GO:0007155cell adhesionTASbiological_process
GO:0044255cellular lipid metabolic processIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030479actin cortical patchIEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0042493response to drugIEAbiological_process
GO:0003779actin bindingIEAmolecular_function
GO:0006661phosphatidylinositol biosynthetic processIEAbiological_process
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0008156negative regulation of DNA replicationIEAbiological_process
GO:0097178ruffle assemblyIEAbiological_process
GO:0006006glucose metabolic processIEAbiological_process
GO:0006897endocytosisIMPbiological_process
GO:0005547phosphatidylinositol-3,4,5-trisphosphate bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0030027lamellipodiumIEAcellular_component
GO:0004445inositol-polyphosphate 5-phosphatase activityIEAmolecular_function
GO:0009791post-embryonic developmentIEAbiological_process


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