| UniProt/SwissProt ID: | DAG1_HUMAN |
| Description: | dystroglycan 1 (dystrophin-associated glycoprotein 1) [Source:HGNC Symbol;Acc:2666] |
| Location: | chr3 p21.31 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T884 | RPKNMtPYRSP | HPRD | |
| Y892 | RSPPPyVPP | SRC | RegPhos |
| Y892 | RSPPPyVPP__ | DAG1 | PhosphoSitePlus |
| T790 | LEDQAtFIKKG | HPRD | |
| Y892 | RSPPPyVPP | Src | RegPhos |
| T478 | TASPPtRIRTT | PhosphoSitePlus | |
| Y892 | RSPPPyV | SRC | HPRD; phosphoELM |
| S814 | PPPSSsMPLIL | DAG1 | PhosphoSitePlus |
| S888 | MTPYRsPPPYV | DAG1 | PhosphoSitePlus |
| T469 | TKVSItRLETA | PhosphoSitePlus | |
| Y886 | KNMTPyRSPPP | DAG1 | PhosphoSitePlus |
| S485 | IRTTTsGVPRG | PhosphoSitePlus; HPRD | |
| T203 | DLTKMtPKQRI | PhosphoSitePlus | |
| Y886 | KNMTPyRSPPP | HPRD | |
| S216 | LHRMRsFSEVE | PhosphoSitePlus | |
| Y863 | PNAPPyQPPPP | DAG1 | PhosphoSitePlus |
| S888 | MTPYRsPPPYV | HPRD | |
| S218 | RMRSFsEVELH | PhosphoSitePlus | |
| S812 | SKPPPsSSMPL | DAG1 | PhosphoSitePlus |
| T790 | LEDQAtFIKKG | DAG1 | PhosphoSitePlus |
| T884 | RPKNMtPYRSP | DAG1 | PhosphoSitePlus |
| S812 | SKPPPsSSMPL | HPRD | |
| Dephosphorylation site |
| DAG1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000312435 | P868S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000312435 | V656M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000312435 | V228L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000440590 | V228L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000440705 | V228L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000440590 | V656M | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000439334 | V656M | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000440705 | V656M | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000442600 | V656M | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000312435 | R311W | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000312435 | V228L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000442600 | V228L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000439334 | V228L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000312435 | V656M | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000438421 | V656M | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000312435 | R541Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000438421 | V228L | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000312435 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.83 | 16470630 |
| Hyperphosphorylation site |
| DAG1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SRC_HUMAN | DAG1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05416 | Viral myocarditis |
| hsa05410 | Hypertrophic cardiomyopathy (HCM) |
| hsa05414 | Dilated cardiomyopathy |
| hsa04512 | ECM-receptor interaction |
| hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (A |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016010 | dystrophin-associated glycoprotein complex | IDA | cellular_component |
| GO:0060445 | branching involved in salivary gland morphogenesis | IEA | biological_process |
| GO:0016011 | dystroglycan complex | IEA | cellular_component |
| GO:0007016 | cytoskeletal anchoring at plasma membrane | IEA | biological_process |
| GO:0070938 | contractile ring | IDA | cellular_component |
| GO:0017166 | vinculin binding | IPI | molecular_function |
| GO:0005925 | focal adhesion | IDA | cellular_component |
| GO:0045121 | membrane raft | IEA | cellular_component |
| GO:0042169 | SH2 domain binding | IDA | molecular_function |
| GO:0022011 | myelination in peripheral nervous system | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0034453 | microtubule anchoring | IMP | biological_process |
| GO:0005615 | extracellular space | IDA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0002011 | morphogenesis of an epithelial sheet | IEA | biological_process |
| GO:0014044 | Schwann cell development | IEA | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005856 | cytoskeleton | IEA | cellular_component |
| GO:0043237 | laminin-1 binding | ISS | molecular_function |
| GO:0030175 | filopodium | IDA | cellular_component |
| GO:0019048 | virus-host interaction | IDA | biological_process |
| GO:0021682 | nerve maturation | IEA | biological_process |
| GO:0051898 | negative regulation of protein kinase B signaling | IMP | biological_process |
| GO:0051393 | alpha-actinin binding | IDA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0015631 | tubulin binding | IDA | molecular_function |
| GO:0008307 | structural constituent of muscle | IMP | molecular_function |
| GO:0005604 | basement membrane | IEA | cellular_component |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0030027 | lamellipodium | IDA | cellular_component |
| GO:0043409 | negative regulation of MAPK cascade | IMP | biological_process |
| GO:0006509 | membrane protein ectodomain proteolysis | IDA | biological_process |
| GO:0005654 | nucleoplasm | IDA | cellular_component |
| GO:0003779 | actin binding | IDA | molecular_function |
| GO:0033268 | node of Ranvier | IEA | cellular_component |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0045211 | postsynaptic membrane | IEA | cellular_component |
| GO:0042383 | sarcolemma | IEA | cellular_component |
| GO:0006607 | NLS-bearing substrate import into nucleus | IDA | biological_process |
| GO:0060441 | epithelial tube branching involved in lung morphog | IEA | biological_process |
| GO:0030336 | negative regulation of cell migration | IMP | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016021 | integral to membrane | IDA | cellular_component |
| GO:0009279 | cell outer membrane | IEA | cellular_component |