Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:VILI_HUMAN
Description:villin 1 [Source:HGNC Symbol;Acc:12690]
Location:chr2 q35
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y81GAAAIyTTQMDGelsolinPhosphoSitePlus
Y81GAAAIyTTQMDSRCHPRD; RegPhos
Y555TQSCCyLWCGKGelsolinPhosphoSitePlus
Y134VETNSyDVQRLPhosphoSitePlus
Y725SNTKSyEDLKAPhosphoSitePlus
T206ERGGRtYVGVVGelsolinPhosphoSitePlus
Y60ASSLSyDIHYWphosphoELM; RegPhos
Y60ASSLSyDIHYWGelsolinPhosphoSitePlus
Y256AALKLyHVSDSPhosphoSitePlus
S356ASNRTsGLGKTPhosphoSitePlus
S5_MTKLsAQVKGPhosphoSitePlus
Y64SYDIHyWIGQDGelsolinPhosphoSitePlus
T15GSLNItTPGLQPhosphoSitePlus
Y60ASSLSyDIHYWSRCHPRD; RegPhos
Y256AALKLyHVSDSSRCHPRD; RegPhos
Y324IKAKQyPPSTQGelsolinPhosphoSitePlus
Y46FDGDCyIILAIGelsolinPhosphoSitePlus
Y207RGGRTyVGVVDGelsolinPhosphoSitePlus
Y286SHEDCyILDQGGelsolinPhosphoSitePlus
T2____MtKLSAQPhosphoSitePlus
Y604GGKAPyANTKRPhosphoSitePlus
Y681TTAQEyLKTHPGelsolinPhosphoSitePlus
Y461ITASAyQAVILGelsolinPhosphoSitePlus

Dephosphorylation site
VILI_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000248444R495CTCGAOvarian Cancer21720365, 18772890
ENSP00000248444R198*BIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000248444Hepatocellular CarcinomaMetastasiscell lineUp2.619016532

Hyperphosphorylation site
VILI_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SRC_HUMANVILI_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANVILI_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
VILI_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030175filopodiumIEAcellular_component
GO:0035729cellular response to hepatocyte growth factor stimIEAbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseIEAbiological_process
GO:0061041regulation of wound healingIEAbiological_process
GO:0032433filopodium tipIEAcellular_component
GO:0009617response to bacteriumIDAbiological_process
GO:0051015actin filament bindingIDAmolecular_function
GO:0051014actin filament severingIDAbiological_process
GO:0071364cellular response to epidermal growth factor stimuIDAbiological_process
GO:0032432actin filament bundleIDAcellular_component
GO:0010634positive regulation of epithelial cell migrationIDAbiological_process
GO:0043027cysteine-type endopeptidase inhibitor activity invIEAmolecular_function
GO:0005546phosphatidylinositol-4,5-bisphosphate bindingIDAmolecular_function
GO:0003779actin bindingIEAmolecular_function
GO:0030175filopodiumIDAcellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0030041actin filament polymerizationIDAbiological_process
GO:0001726ruffleIDAcellular_component
GO:0051125regulation of actin nucleationIDAbiological_process
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0060327cytoplasmic actin-based contraction involved in ceIDAbiological_process
GO:0051693actin filament cappingIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008360regulation of cell shapeIDAbiological_process
GO:0005509calcium ion bindingIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:2000392regulation of lamellipodium morphogenesisIEAbiological_process
GO:0005902microvillusIDAcellular_component
GO:0032233positive regulation of actin filament bundle assemIDAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayIDAbiological_process
GO:0007010cytoskeleton organizationIEAbiological_process
GO:0030027lamellipodiumIEAcellular_component
GO:0006461protein complex assemblyTASbiological_process
GO:0035727lysophosphatidic acid bindingIDAmolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0030042actin filament depolymerizationIDAbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23