Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FHIT_HUMAN
Description:fragile histidine triad [Source:HGNC Symbol;Acc:3701]
Location:chrHG1091_PATCH p14.
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y114RNDSIyEELQKPhosphoSitePlus; phosphoELM; RegPhos
Y145AALRVyFQRegPhos
Y114RNDSIyEELQKSRCHPRD; RegPhos

Dephosphorylation site
FHIT_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000418582E132QBIOMARTBreast Cancer21930507, 21930502
ENSP00000417480E132QBIOMARTBreast Cancer21930507, 21930502
ENSP00000417480R51HBIOMARTBreast Cancer21930507, 21930502
ENSP00000342087R51HBIOMARTBreast Cancer21930507, 21930502
ENSP00000417557R51HBIOMARTBreast Cancer21930507, 21930502
ENSP00000418582R51HBIOMARTBreast Cancer21930507, 21930502
ENSP00000342087E132QBIOMARTBreast Cancer21930507, 21930502
ENSP00000417557E132QBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000342087Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.5615169874

Hyperphosphorylation site
FHIT_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SRC_HUMANFHIT_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANFHIT_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05223Non-small cell lung cancer
hsa00230Purine metabolism
hsa05222Small cell lung cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0009117nucleotide metabolic processTASbiological_process
GO:0006260DNA replicationIEAbiological_process
GO:0047710bis(5'-adenosyl)-triphosphatase activityIDAmolecular_function
GO:0003824catalytic activityTASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0016787hydrolase activityIEAmolecular_function


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