Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DAPP1_HUMAN
Description:dual adaptor of phosphotyrosine and 3-phosphoinositides [Source:HGNC Symbol;Acc:16500]
Location:chr4 q23
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y139EEPSIyESVRVLCKHPRD; RegPhos; SysPTM
Y139EEPSIyESVRVLckphosphoELM; RegPhos; SysPTM
Y138VEEPSiYESVRHPRD
S276TIRSRsFIFK_PhosphoSitePlus
Y139EEPSIyESVRVLYNHPRD; RegPhos; SysPTM
Y139EEPSIyESVRVBTKHPRD; RegPhos; SysPTM
Y139EEPSIyESVRVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S137KVEEPsIYESVPhosphoSitePlus
Y139EEPSIyESVRVSRCHPRD; RegPhos; SysPTM
S141PSIYEsVRVHTPhosphoSitePlus; RegPhos

Dephosphorylation site
DAPP1_HUMAN do not have dephosphorylation site.

Mutation site
DAPP1_HUMAN do not have mutation site.

Differential expressed protein
DAPP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DAPP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANDAPP1_HUMANkinase -> substrateRegPhos
BTK_HUMANDAPP1_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANDAPP1_HUMANkinase -> substrateHPRD; RegPhos
LCK_HUMANDAPP1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
LYN_HUMANDAPP1_HUMANkinase -> substrateKEGG; HPRD; RegPhos
DAPP1_HUMANRAC1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04662B cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006470protein dephosphorylationNASbiological_process
GO:0035335peptidyl-tyrosine dephosphorylationNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005543phospholipid bindingNASmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0043325phosphatidylinositol-3,4-bisphosphate bindingIDAmolecular_function
GO:0005547phosphatidylinositol-3,4,5-trisphosphate bindingIDAmolecular_function
GO:0004725protein tyrosine phosphatase activityNASmolecular_function


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