Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FAK1_HUMAN
Description:PTK2 protein tyrosine kinase 2 [Source:HGNC Symbol;Acc:9611]
Location:chr8 q24.3
Node attribute:PPI(target); PPI(source); substrate; kinase; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T914ISPPPtANLDRFocal_ATPhosphoSitePlus
S461CKNCTsDSVREPkinase_TyrPhosphoSitePlus
Y577EDSTYyKASKGFAKphosphoELM; RegPhos
Y761MAGSIyPGQASPhosphoSitePlus
S568GDFGLsRYMEDPkinase_TyrPhosphoSitePlus; SysPTM
T460TCKNCtSDSVRPkinase_TyrPhosphoSitePlus
Y883GNQHIyQPVGKSRCHPRD
Y947SNDKVyENVTGSRCHPRD
Y1007KLAQQyVMTSLFocal_ATPhosphoSitePlus
S920ANLDRsNDKVYFocal_ATPhosphoSitePlus
T967RTLLAtVDETIFocal_ATPhosphoSitePlus
Y576MEDSTyYKASKphosphoELM; SysPTM
Y925SNDKVyENVTGphosphoELM; RegPhos
S16NHTPNsSTKTHPhosphoSitePlus; HPRD
S738APPKPsRPGYPHPRD
S722RPGYPsPRSSEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S568GDFGLsRYMEDHPRD; SysPTM
S463NCTSDsVREKFPkinase_TyrPhosphoSitePlus
S892SLASLsSPADSHPRD; phosphoELM
S390RTHAVsVSETDPhosphoSitePlus
S732EGFYPsPQHMVROCK1phosphoELM; RegPhos
T971ATVDEtIPLLPFocal_ATPhosphoSitePlus
Y570FGLSRyMEDSTHPRD; phosphoELM; SysPTM
S850DREDGsLQGPIPhosphoSitePlus
S862PDVRLsRGSIDHPRD
S38NHTPNsSTKTHHPRD
S574RYMEDsTYYKAPkinase_TyrPhosphoSitePlus
Y194EKKSNyEVLEKFERM_MPhosphoSitePlus
S732EGFYPsPQHMVPhosphoSitePlus
T700SRRQAtVSWDSPhosphoSitePlus
S716APPKPsRPGYPHPRD
T406IDEEDtYTMPSPhosphoSitePlus
S51TGMERsPGAMEHPRD
S872DREDGsLQGPIPTK2HPRD
S727TVSWDsGGSDEHPRD
S759TAMAGsIYPGQPhosphoSitePlus
S914SLASLsSPADSHPRD
S412RTHAVsVSETDPTK2HPRD
S840PDVRLsRGSIDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S744RPGYPsPRSSEHPRD
S705TVSWDsGGSDEPhosphoSitePlus; HPRD
Y576MEDSTyYKASKPkinase_TyrPhosphoSitePlus; SysPTM
S726PSPRSsEGFYPPhosphoSitePlus
Y599EDSTYyKASKGRETHPRD
Y1038SLQQEyKKQMLHPRD
Y947SNDKVyENVTGPTK2HPRD
Y5_MAAAyLDPNLPhosphoSitePlus
S590GDFGLsRYMEDHPRD
S910QPQEIsPPPTAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y598MEDSTyYKASKSRCHPRD
Y1016SLQQEyKKQMLHPRD
S850DREDGsLQGPIPTK2HPRD
Y598MEDSTyYKASKRETHPRD
T46KTHLGtGMERSHPRD
S517QVRKYsLDLASPkinase_TyrPhosphoSitePlus
T35PNLNHtPNSSTHPRD
Y592FGLSRyMEDSTHPRD
T394VSVSEtDDYAEPhosphoSitePlus
Y925SNDKVyENVTGPTK2HPRD
Y148TLNFFyQQVKSFERM_MPhosphoSitePlus
Y576MEDSTyYKASKINSRHPRD; RegPhos; SysPTM
S390RTHAVsVSETDPTK2HPRD
Y570FGLSRyMEDSTPkinase_TyrPhosphoSitePlus; SysPTM
T408EEDTYtMPSTRPhosphoSitePlus
T936ISPPPtANLDRHPRD
Y861GNQHIyQPVGKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y577EDSTYyKASKGautocatalysisRegPhos
Y397SETDDyAEIIDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T408KQGMRtHAVSVHPRD
S932QPQEIsPPPTAHPRD
S909PGHLGsLASLSHPRD
S29TGMERsPGAMEPhosphoSitePlus; HPRD; SysPTM
Y925SNDKVyENVTGFocal_ATPhosphoSitePlus
S695RMRMEsRRQATPhosphoSitePlus
Y397SETDDyAEIIDFAKphosphoELM; RegPhos
S392HAVSVsETDDYPhosphoSitePlus
T386KQGMRtHAVSVPhosphoSitePlus; HPRD
Y407DEEDTyTMPSTPhosphoSitePlus; phosphoELM; RegPhos
Y577EDSTYyKASKGRETHPRD; RegPhos
Y898SPADSyNEGVKPhosphoSitePlus
Y441VHQGIyMSPENPkinase_TyrPhosphoSitePlus
T805GQVLPtHLMEEPhosphoSitePlus
Y429DEEDTyTMPSTPTK2BHPRD
Y599EDSTYyKASKGSRCHPRD
Y397SETDDyAEIIDCRKHPRD
Y598MEDSTyYKASKINSRHPRD
S702RQATVsWDSGGPhosphoSitePlus
Y407DEEDTyTMPSTSRCHPRD; RegPhos
Y577EDSTYyKASKGPkinase_TyrPhosphoSitePlus
Y397SETDDyAEIIDPTK2HPRD
Y925SNDKVyENVTGSRCHPRD; RegPhos
T929VYENVtGLVKAFocal_ATPhosphoSitePlus
Y576MEDSTyYKASKautocatalysisRegPhos; SysPTM
Y925SNDKVyENVTGFAKRegPhos
Y419SETDDyAEIIDPTK2HPRD
Y577EDSTYyKASKGINSRHPRD; RegPhos
S865RLSRGsIDREDHPRD
Y429DEEDTyTMPSTSRCHPRD
Y347DLIDGyCRLVNPhosphoSitePlus; phosphoELM; RegPhos
S887PGHLGsLASLSPhosphoSitePlus; HPRD; SysPTM
T575YMEDStYYKASPkinase_TyrPhosphoSitePlus
Y576MEDSTyYKASKSRCHPRD; RegPhos; SysPTM
T503IMELCtLGELRPkinase_TyrPhosphoSitePlus
Y861GNQHIyQPVGKSrcRegPhos
Y577EDSTYyKASKGHPRD; phosphoELM
Y576MEDSTyYKASKRETHPRD; RegPhos; SysPTM
Y720PSRPGyPSPRSPhosphoSitePlus
Y742VQTNHyQVSGYPhosphoSitePlus
Y576MEDSTyYKASKFAKphosphoELM; RegPhos; SysPTM
Y861GNQHIyQPVGKSRCHPRD; phosphoELM; RegPhos
Y407DEEDTyTMPSTPYK2RegPhos
S443QGIYMsPENPAPkinase_TyrPhosphoSitePlus
Y407DEEDTyTMPSTPTK2BHPRD
Y599EDSTYyKASKGINSRHPRD
S677LKAQLsTILEEPhosphoSitePlus
Y155QVKSDyMLEIAFERM_MPhosphoSitePlus
Y397SETDDyAEIIDP46108(CRKRegPhos
T13PNLNHtPNSSTPhosphoSitePlus; HPRD; SysPTM
S580TYYKAsKGKLPPkinase_TyrPhosphoSitePlus
Y577EDSTYyKASKGSRCHPRD; RegPhos
S843RLSRGsIDREDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T914ISPPPtANLDRHPRD
T24KTHLGtGMERSHPRD

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y419SVSETDDyAEIIDEEPTPN12HPRD
Y397SVSETDDyAEIIDEEPTPN12HPRD
Y419SVSETDDyAEIIDEEHPRD
Y397SVSETDDyAEIIDEEHPRD

Mutation site
FAK1_HUMAN do not have mutation site.

Differential expressed protein
FAK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y407IIDEEDTyTMPSTRDcolorectal cancer12871985PhosphoSitePlus
Y397SVSETDDyAEIIDEEcolorectal cancer12871985PhosphoSitePlus
Y925Focal_ATDRSNDKVyENVTGLVcholangiocellular carcinoma21253578PhosphoSitePlus
Y397SVSETDDyAEIIDEEhepatocellular carcinoma20180147PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
FAK1_HUMANSMYD2_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANSHC3_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANSCG1_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANACTN1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
SRC_HUMANFAK1_HUMANkinase -> substrateRegPhos; NetPath
FAK1_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANFAK1_HUMANkinase -> substrateRegPhos; NetPath
RET_HUMANFAK1_HUMANkinase -> substrateRegPhos
FAK1_HUMANBCAR1_HUMANkinase -> substrateRegPhos
FAK1_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
ROCK1_HUMANFAK1_HUMANkinase -> substrateRegPhos
FAK1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANTHIO_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANSRC_HUMANkinase -> substrateKEGG
FAK1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANSHC2_HUMANkinase -> substrateKEGG
FAK1_HUMANBMX_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
FAK1_HUMANTERF1_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANFAK1_HUMANkinase -> substrateKEGG
FAK2_HUMANFAK1_HUMANkinase -> substrateHPRD; RegPhos
CRK_HUMANFAK1_HUMANkinase -> substrateHPRD
FAK1_HUMANKC1G2_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANRGRF1_HUMANkinase -> substrateKEGG
ZAGL2_HUMANFAK1_HUMANkinase -> substrateRegPhos
FAK1_HUMANPAXI_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
FAK1_HUMANCSN6_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANTRIO_HUMANkinase -> substrateHPRD; RegPhos
FAK1_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANMITF_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANCDK9_HUMANkinase -> substrateRobert H Newman (2013)
INSR_HUMANFAK1_HUMANkinase -> substrateRegPhos
FAK1_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANXRCC4_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANPRIO_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANSH3G1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PTN12_HUMANFAK1_HUMANphosphatase -> substrateHPRD
PTEN_HUMANFAK1_HUMANphosphatase -> substrateKEGG
FAK1_HUMANPI3R5_HUMANotherKEGG
VGFR2_HUMANFAK1_HUMANotherKEGG
FAK1_HUMANGRB2_HUMANotherKEGG
ITB1_HUMANFAK1_HUMANotherKEGG
EGFR_HUMANFAK1_HUMANotherKEGG
FAK1_HUMANCAN2_HUMANotherKEGG
TF65_HUMANFAK1_HUMANTF -> target geneTRANSFAC
P53_HUMANFAK1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa05222Small cell lung cancer
hsa04062Chemokine signaling pathway
hsa05146Amoebiasis
hsa04510Focal adhesion
hsa05100Bacterial invasion of epithelial cells
hsa05202Transcriptional misregulation in cancer
hsa04360Axon guidance
hsa04012ErbB signaling pathway
hsa04370VEGF signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04670Leukocyte transendothelial migration

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0014704intercalated discIEAcellular_component
GO:0040023establishment of nucleus localizationIEAbiological_process
GO:0003779actin bindingIDAmolecular_function
GO:0043548phosphatidylinositol 3-kinase bindingIEAmolecular_function
GO:0050766positive regulation of phagocytosisIEAbiological_process
GO:0016604nuclear bodyIEAcellular_component
GO:0042127regulation of cell proliferationIMPbiological_process
GO:0005178integrin bindingIEAmolecular_function
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0050771negative regulation of axonogenesisIEAbiological_process
GO:0003007heart morphogenesisTASbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0008284positive regulation of cell proliferationISSbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0016324apical plasma membraneIEAcellular_component
GO:0014068positive regulation of phosphatidylinositol 3-kinaIMPbiological_process
GO:0032355response to estradiol stimulusIEAbiological_process
GO:0046621negative regulation of organ growthIEAbiological_process
GO:0004672protein kinase activityTASmolecular_function
GO:2000060positive regulation of protein ubiquitination invoIEAbiological_process
GO:0001570vasculogenesisIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0001890placenta developmentTASbiological_process
GO:0008360regulation of cell shapeIMPbiological_process
GO:0060396growth hormone receptor signaling pathwayIDAbiological_process
GO:0045785positive regulation of cell adhesionIEAbiological_process
GO:0051493regulation of cytoskeleton organizationTASbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0022408negative regulation of cell-cell adhesionIDAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0007254JNK cascadeIEAbiological_process
GO:0030198extracellular matrix organizationIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0030336negative regulation of cell migrationIEAbiological_process
GO:0033628regulation of cell adhesion mediated by integrinIDAbiological_process
GO:0014911positive regulation of smooth muscle cell migratioIEAbiological_process
GO:0007229integrin-mediated signaling pathwayIMPbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0007172signal complex assemblyIEAbiological_process
GO:0046685response to arsenic-containing substanceIEAbiological_process
GO:0030644cellular chloride ion homeostasisIEAbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0030027lamellipodiumIEAcellular_component
GO:0008432JUN kinase bindingIDAmolecular_function
GO:0010243response to organic nitrogenIEAbiological_process
GO:0048661positive regulation of smooth muscle cell proliferIEAbiological_process
GO:0021955central nervous system neuron axonogenesisIEAbiological_process
GO:0005829cytosolIDAcellular_component
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:0030307positive regulation of cell growthIEAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0005730nucleolusIEAcellular_component
GO:0045444fat cell differentiationIEAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0042493response to drugIEAbiological_process
GO:0009790embryo developmentTASbiological_process
GO:0045667regulation of osteoblast differentiationIMPbiological_process
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0043552positive regulation of phosphatidylinositol 3-kinaTASbiological_process
GO:0060252positive regulation of glial cell proliferationIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0000226microtubule cytoskeleton organizationIEAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0030010establishment of cell polarityTASbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0042383sarcolemmaIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0045909positive regulation of vasodilationIEAbiological_process
GO:0000165MAPK cascadeIEAbiological_process
GO:0048013ephrin receptor signaling pathwayIDAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0042169SH2 domain bindingIPImolecular_function
GO:0038007netrin-activated signaling pathwayTASbiological_process
GO:0005856cytoskeletonIEAcellular_component
GO:0005938cell cortexIEAcellular_component
GO:0001934positive regulation of protein phosphorylationIMPbiological_process
GO:0001568blood vessel developmentIEAbiological_process
GO:0051964negative regulation of synapse assemblyIEAbiological_process
GO:0051893regulation of focal adhesion assemblyTASbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0010594regulation of endothelial cell migrationTASbiological_process
GO:0050806positive regulation of synaptic transmissionIEAbiological_process
GO:0001764neuron migrationIEAbiological_process
GO:0032319regulation of Rho GTPase activityTASbiological_process
GO:2000811negative regulation of anoikisIMPbiological_process
GO:0043542endothelial cell migrationIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0048870cell motilityTASbiological_process
GO:0051897positive regulation of protein kinase B signaling IMPbiological_process
GO:0005925focal adhesionIEAcellular_component
GO:0045860positive regulation of protein kinase activityIMPbiological_process
GO:0005815microtubule organizing centerIEAcellular_component