Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GNAS2_HUMAN
Description:GNAS complex locus [Source:HGNC Symbol;Acc:4392]
Location:chr20 q13.32
Node attribute:Gprotein

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S334EFLRIsTASGDHPRD
Y311SKIEDyFPEFAG-alphaPhosphoSitePlus
Y360GRHYCyPHFTCG-alphaPhosphoSitePlus
Y190IKQADyVPSDQG-alphaPhosphoSitePlus
Y177IDCAQyFLDKIG-alphaPhosphoSitePlus
S337RISTAsGDGRHHPRD
S338RISTAsGDGRHHPRD
S352RISTAsGDGRHG-alphaPhosphoSitePlus
Y391MHLRQyELL__G-alphaPhosphoSitePlus
S193ADYVPsDQDLLG-alphaPhosphoSitePlus
T204RCRVLtSGIFEG-alphaPhosphoSitePlus
T210SGIFEtKFQVDG-alphaPhosphoSitePlus
S335EFLRIsTASGDHPRD
S352RISTAsGDGRHHPRD
S349EFLRIsTASGDHPRD

Dephosphorylation site
GNAS2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000360126R201CSjoblom2006Pituitary Carcinoma16959974, 1944469, 2549426
ENSP00000360126R844SOMIMPituitary Carcinoma10487696
ENSP00000360126R201HSjoblom2006Pituitary Carcinoma12727968, 1594625, 16959974, 1944469, 2549426
ENSP00000360126D141VDing2008, COSMICLung Cancer18948947
ENSP00000360126V248MDing2008, COSMICLung Cancer18948947
ENSP00000360126Y163*COSMICOvarian Cancer21720365
ENSP00000360126R201CSjoblom2006Intestines Cancer16959974, 1944469, 2549426
ENSP00000360126R201HSjoblom2006Intestines Cancer12727968, 1594625, 16959974, 1944469, 2549426
ENSP00000360126Y163*TCGAOvarian Cancer21720365, 18772890
ENSP00000360126F273LCOSMICOvarian Cancer21720365
ENSP00000360126Q227RCOSMICPituitary Carcinoma20688896
ENSP00000360136R187CBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000265620R186CBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000360126L203PCOSMICThyroid Carcinoma18694911
ENSP00000360126N97SCOSMICHead and Neck Cancer21798893
ENSP00000360126R201LHPINeoplasms by Histologic Type7751320
ENSP00000360126Q870ROMIMPituitary Carcinoma2549426 7737262
ENSP00000360126R201CCOSMICIntestines Cancer16959974

Differential expressed protein
GNAS2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GNAS2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ADRB3_HUMANGNAS2_HUMANGPCR -> GproteingpDB
GPR12_HUMANGNAS2_HUMANGPCR -> GproteingpDB
TAAR6_HUMANGNAS2_HUMANGPCR -> GproteingpDB
MC3R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
PE2R3_HUMANGNAS2_HUMANGPCR -> GproteingpDB
PD2R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
VIPR2_HUMANGNAS2_HUMANGPCR -> GproteingpDB
ADRB2_HUMANGNAS2_HUMANGPCR -> GproteingpDB
TAAR8_HUMANGNAS2_HUMANGPCR -> GproteingpDB
GLR_HUMANGNAS2_HUMANGPCR -> GproteingpDB
GPR63_HUMANGNAS2_HUMANGPCR -> GproteingpDB
TAAR2_HUMANGNAS2_HUMANGPCR -> GproteingpDB
GPR6_HUMANGNAS2_HUMANGPCR -> GproteingpDB
CALCR_HUMANGNAS2_HUMANGPCR -> GproteingpDB
DRD1_HUMANGNAS2_HUMANGPCR -> GproteingpDB
GLP2R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
LSHR_HUMANGNAS2_HUMANGPCR -> GproteingpDB
ACTHR_HUMANGNAS2_HUMANGPCR -> GproteingpDB
PTH1R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
PE2R2_HUMANGNAS2_HUMANGPCR -> GproteingpDB
CRFR1_HUMANGNAS2_HUMANGPCR -> GproteingpDB
5HT6R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
EDNRA_HUMANGNAS2_HUMANGPCR -> GproteingpDB
SCTR_HUMANGNAS2_HUMANGPCR -> GproteingpDB
VIPR1_HUMANGNAS2_HUMANGPCR -> GproteingpDB
GLP1R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
TAAR1_HUMANGNAS2_HUMANGPCR -> GproteingpDB
5HT4R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
DRD5_HUMANGNAS2_HUMANGPCR -> GproteingpDB
P2Y11_HUMANGNAS2_HUMANGPCR -> GproteingpDB
FSHR_HUMANGNAS2_HUMANGPCR -> GproteingpDB
GHRHR_HUMANGNAS2_HUMANGPCR -> GproteingpDB
ADA2A_HUMANGNAS2_HUMANGPCR -> GproteingpDB
MC4R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
NK3R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
5HT7R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
V2R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
NK2R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
LPAR4_HUMANGNAS2_HUMANGPCR -> GproteingpDB
PE2R4_HUMANGNAS2_HUMANGPCR -> GproteingpDB
HRH2_HUMANGNAS2_HUMANGPCR -> GproteingpDB
PTH2R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
ADRB1_HUMANGNAS2_HUMANGPCR -> GproteingpDB
MSHR_HUMANGNAS2_HUMANGPCR -> GproteingpDB
GIPR_HUMANGNAS2_HUMANGPCR -> GproteingpDB
CRFR2_HUMANGNAS2_HUMANGPCR -> GproteingpDB
GNAS2_HUMANADCY2_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBB5_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GNAS2_HUMANADCY8_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBD_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBB3_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBB4A_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBB1_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GNAS2_HUMANADCY7_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBA8_HUMANGprotein -> effectorgpDB
GNAS2_HUMANADCY5_HUMANGprotein -> effectorgpDB
GNAS2_HUMANSNX13_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBB6_HUMANGprotein -> effectorgpDB
GNAS2_HUMANADCY6_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBB2B_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBG1_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GNAS2_HUMANADCY9_HUMANGprotein -> effectorgpDB
GNAS2_HUMANCSK_HUMANGprotein -> effectorgpDB
GNAS2_HUMANADCY1_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBE_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBB8_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBA3C_HUMANGprotein -> effectorgpDB
GNAS2_HUMANSRC_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBA3E_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBA1C_HUMANGprotein -> effectorgpDB
GNAS2_HUMANADCY3_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBAL3_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBG2_HUMANGprotein -> effectorgpDB
GNAS2_HUMANADCY4_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBB2A_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBA4B_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05030Cocaine addiction
hsa04916Melanogenesis
hsa04730Long-term depression
hsa04540Gap junction
hsa04728Dopaminergic synapse
hsa04726Serotonergic synapse
hsa04961Endocrine and other factor-regulated calcium reabs
hsa05032Morphine addiction
hsa04742Taste transduction
hsa04912GnRH signaling pathway
hsa05031Amphetamine addiction
hsa05414Dilated cardiomyopathy
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa05146Amoebiasis
hsa05034Alcoholism
hsa04962Vasopressin-regulated water reabsorption
hsa04270Vascular smooth muscle contraction
hsa04020Calcium signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04970Salivary secretion
hsa05110Vibrio cholerae infection
hsa04976Bile secretion
hsa04724Glutamatergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006833water transportTASbiological_process
GO:0005834heterotrimeric G-protein complexISScellular_component
GO:0006171cAMP biosynthetic processTASbiological_process
GO:0019001guanyl nucleotide bindingIEAmolecular_function
GO:0007608sensory perception of smellTASbiological_process
GO:0007191adenylate cyclase-activating dopamine receptor sigISSbiological_process
GO:0007190activation of adenylate cyclase activityTASbiological_process
GO:0050796regulation of insulin secretionTASbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0071377cellular response to glucagon stimulusTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0004016adenylate cyclase activityTASmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0071380cellular response to prostaglandin E stimulusISSbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0032588trans-Golgi network membraneIDAcellular_component
GO:0031224intrinsic to membraneIDAcellular_component
GO:0046907intracellular transportNASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0031683G-protein beta/gamma-subunit complex bindingIEAmolecular_function
GO:0071870cellular response to catecholamine stimulusISSbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0003924GTPase activityTASmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0006184GTP catabolic processTASbiological_process
GO:0006112energy reserve metabolic processTASbiological_process