Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NMDE1_HUMAN
Description:glutamate receptor, ionotropic, N-methyl D-aspartate 2A [Source:HGNC Symbol;Acc:4585]
Location:chr16 p13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S906AKNISsMSNMNNMDAR2_CPhosphoSitePlus
Y1187DQYKLySKHFTNMDAR2_CPhosphoSitePlus
S905SAKNIsSMSNMNMDAR2_CPhosphoSitePlus
Y1267TGEQVyQQDWANMDAR2_CPhosphoSitePlus
T888PDFNLtGSQSNRegPhos
S917SSRMDsPKRAANMDAR2_CPhosphoSitePlus
S912MSNMNsSRMDSHPRD; phosphoELM; RegPhos
S1291ISRQHsYDNIVCAMK2AHPRD
S1291ISRQHsYDNIVCAMK2BHPRD
Y1105EVERTyLKTKSSRCHPRD; RegPhos
Y1423GHNDVyISEHVNMDAR2_CPhosphoSitePlus
S1232HFTMRsPFKCDCDK_groupphosphoELM; RegPhos
S1337PSSKLsGKKSSHPRD; RegPhos; SysPTM
S929FIQRGsLIMDMRegPhos
Y1184SNNDQyKLYSKNMDAR2_CPhosphoSitePlus
Y1118PRDKIyTIDGENMDAR2_CPhosphoSitePlus
Y730LDAFIyDAAVLSBP_bac_3; Lig_chanPhosphoSitePlus
S917SSRMDsPKRAAHPRD; phosphoELM; RegPhos
Y1387CPSDPyKHSLPSRCHPRD; RegPhos
Y737AAVLNyKAGRDSBP_bac_3; Lig_chanPhosphoSitePlus
S912MSNMNsSRMDSNMDAR2_CPhosphoSitePlus
Y1105EVERTyLKTKSNMDAR2_CPhosphoSitePlus
S1416YCSRDsRGHNDPKCaRegPhos
Y1246RMGNLyDIDEDNMDAR2_CPhosphoSitePlus
Y943KGNLMySDNRSRegPhos
S913SNMNSsRMDSPNMDAR2_CPhosphoSitePlus
Y1387CPSDPyKHSLPNMDAR2_CPhosphoSitePlus
S1025SIRQDsLSQNPRegPhos
S1232HFTMRsPFKCDCDK5HPRD; RegPhos
Y943KGNLMySDNRSNMDAR2_CPhosphoSitePlus
S908NISSMsNMNSSNMDAR2_CPhosphoSitePlus
T749GCKLVtIGSGYSBP_bac_3; Lig_chanPhosphoSitePlus
S1459YKKMPsIESDVRegPhos
S1291ISRQHsYDNIVCaMK2aRegPhos
S1291ISRQHsYDNIVCaMK2bRegPhos
Y1325LEGNFyGSLFSNMDAR2_CPhosphoSitePlus
Y1267TGEQVyQQDWASRCHPRD; RegPhos
S1416YCSRDsRGHNDPRKCAHPRD

Dephosphorylation site
NMDE1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000379818R1206*COSMICOvarian Cancer21720365
ENSP00000379818G712ECOSMICMelanoma21499247
ENSP00000379818P57HCOSMICMelanoma21499247
ENSP00000332549E962KCOSMICMelanoma21499247
ENSP00000379820G532ECOSMICOvarian Cancer21720365
ENSP00000379820D1153NCOSMICMelanoma21499247
ENSP00000379820W7*COSMICMelanoma21499247
ENSP00000379818D1153NCOSMICMelanoma21499247
ENSP00000379818E1073KCOSMICMelanoma21499247
ENSP00000332549S1462CCOSMICMelanoma21499247
ENSP00000379820F183ICOSMICMelanoma21499247
ENSP00000332549R920KCOSMICMelanoma21499247
ENSP00000379820E1175KCOSMICMelanoma21499247
ENSP00000332549A1433VCOSMICHead and Neck Cancer21798893
ENSP00000379820M653ICOSMICMelanoma21499247
ENSP00000379820W1271*COSMICMelanoma21499247
ENSP00000379818G889ECOSMICMelanoma21499247
ENSP00000332549G889ECOSMICMelanoma21499247
ENSP00000379818A302TBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000332549R1206*COSMICOvarian Cancer21720365
ENSP00000379818R1318WCOSMICMelanoma21499247
ENSP00000379820A1276GCOSMICMelanoma21499247
ENSP00000379820N886SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000379818A1433VCOSMICHead and Neck Cancer21798893
ENSP00000379820G449ECOSMICMelanoma21499247
ENSP00000379820R920KCOSMICMelanoma21499247
ENSP00000332549T1223SCOSMICOvarian Cancer21720365
ENSP00000379820K592ECOSMICMelanoma21499247
ENSP00000379820E371KCOSMICMelanoma21499247
ENSP00000379820E1073KCOSMICMelanoma21499247
ENSP00000332549E379KCOSMICMelanoma21499247
ENSP00000379818G740RCOSMICMelanoma21499247
ENSP00000379820S1425LCOSMICMelanoma21499247
ENSP00000332549Q891*COSMICMelanoma21499247
ENSP00000379818D1421NCOSMICMelanoma21499247
ENSP00000379818F459SCOSMICMelanoma21499247
ENSP00000379820G889ECOSMICMelanoma21499247
ENSP00000379818P1366LCOSMICMelanoma21499247
ENSP00000332549G1177RCOSMICHead and Neck Cancer21798893
ENSP00000379820D1421NCOSMICMelanoma21499247
ENSP00000379818S1462CCOSMICMelanoma21499247
ENSP00000379818M653ICOSMICMelanoma21499247
ENSP00000332549S278FCOSMICMelanoma
ENSP00000379818G449ECOSMICMelanoma21499247
ENSP00000379820T1223SCOSMICOvarian Cancer21720365
ENSP00000379818S929FCOSMICMelanoma21499247
ENSP00000379820W343*COSMICMelanoma21499247
ENSP00000379820E379KCOSMICMelanoma21499247
ENSP00000332549G740RCOSMICMelanoma21499247
ENSP00000332549S929FCOSMICMelanoma21499247
ENSP00000379820D252NCOSMICMelanoma21499247
ENSP00000332549D1153NCOSMICMelanoma21499247
ENSP00000379818T1223SCOSMICOvarian Cancer21720365
ENSP00000332549H405DCOSMICBreast Cancer
ENSP00000332549R1285KCOSMICMelanoma21499247
ENSP00000379820S598FCOSMICMelanoma21499247
ENSP00000379818W7*COSMICMelanoma21499247
ENSP00000385872A302TBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000332549E1073KCOSMICMelanoma21499247
ENSP00000379820P1074LCOSMICMelanoma21499247
ENSP00000332549G532ECOSMICOvarian Cancer21720365
ENSP00000379820P1366LCOSMICMelanoma21499247
ENSP00000379818S1425LCOSMICMelanoma21499247
ENSP00000379818S278FCOSMICMelanoma
ENSP00000379820R1285KCOSMICMelanoma21499247
ENSP00000379820H405DCOSMICBreast Cancer
ENSP00000379818F1191ICOSMICRenal Cancer20054297
ENSP00000379820Q891*COSMICMelanoma21499247
ENSP00000332549D252NCOSMICMelanoma21499247
ENSP00000379818P1074LCOSMICMelanoma21499247
ENSP00000332549N886SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000379820S929FCOSMICMelanoma21499247
ENSP00000379818A1276GCOSMICMelanoma21499247
ENSP00000379818W343*COSMICMelanoma21499247
ENSP00000332549E1426KCOSMICMelanoma21499247
ENSP00000332549W378*COSMICMelanoma21499247
ENSP00000379820R1318WCOSMICMelanoma21499247
ENSP00000379818K592ECOSMICMelanoma21499247
ENSP00000379818E1426KCOSMICMelanoma21499247
ENSP00000332549G712ECOSMICMelanoma21499247
ENSP00000379820S1462CCOSMICMelanoma21499247
ENSP00000379820P57HCOSMICMelanoma21499247
ENSP00000332549F459SCOSMICMelanoma21499247
ENSP00000379820A302TBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000379818W378*COSMICMelanoma21499247
ENSP00000379818S598FCOSMICMelanoma21499247
ENSP00000379818E1175KCOSMICMelanoma21499247
ENSP00000332549W7*COSMICMelanoma21499247
ENSP00000332549R1318WCOSMICMelanoma21499247
ENSP00000332549A302TBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000379820A1433VCOSMICHead and Neck Cancer21798893
ENSP00000379820E962KCOSMICMelanoma21499247
ENSP00000332549S598FCOSMICMelanoma21499247
ENSP00000379818G532ECOSMICOvarian Cancer21720365
ENSP00000379818F183ICOSMICMelanoma21499247
ENSP00000332549E371KCOSMICMelanoma21499247
ENSP00000379818R920KCOSMICMelanoma21499247
ENSP00000379818E371KCOSMICMelanoma21499247
ENSP00000379820R1206*COSMICOvarian Cancer21720365
ENSP00000332549D1421NCOSMICMelanoma21499247
ENSP00000332549P57HCOSMICMelanoma21499247
ENSP00000379818E379KCOSMICMelanoma21499247
ENSP00000379818D252NCOSMICMelanoma21499247
ENSP00000332549K592ECOSMICMelanoma21499247
ENSP00000379820G712ECOSMICMelanoma21499247
ENSP00000379818G1177RCOSMICHead and Neck Cancer21798893
ENSP00000332549P1366LCOSMICMelanoma21499247
ENSP00000379820G740RCOSMICMelanoma21499247
ENSP00000332549P1074LCOSMICMelanoma21499247
ENSP00000379820E1426KCOSMICMelanoma21499247
ENSP00000379820F1191ICOSMICRenal Cancer20054297
ENSP00000379820G1177RCOSMICHead and Neck Cancer21798893
ENSP00000379818E962KCOSMICMelanoma21499247
ENSP00000332549W343*COSMICMelanoma21499247
ENSP00000332549E1175KCOSMICMelanoma21499247
ENSP00000379818W1271*COSMICMelanoma21499247
ENSP00000332549W1271*COSMICMelanoma21499247
ENSP00000379820S278FCOSMICMelanoma
ENSP00000385872N886SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000332549A1276GCOSMICMelanoma21499247
ENSP00000332549F183ICOSMICMelanoma21499247
ENSP00000379818Q891*COSMICMelanoma21499247
ENSP00000332549F1191ICOSMICRenal Cancer20054297
ENSP00000379820W378*COSMICMelanoma21499247
ENSP00000379818R1285KCOSMICMelanoma21499247
ENSP00000332549S1425LCOSMICMelanoma21499247
ENSP00000379820F459SCOSMICMelanoma21499247
ENSP00000379818N886SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000332549M653ICOSMICMelanoma21499247
ENSP00000332549G449ECOSMICMelanoma21499247
ENSP00000379818H405DCOSMICBreast Cancer

Differential expressed protein
NMDE1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y1325NMDAR2_CRLLEGNFyGSLFSVPHIV Encephalitis20448061PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANNMDE1_HUMANkinase -> substrateRegPhos
CDK5_HUMANNMDE1_HUMANkinase -> substrateHPRD; RegPhos
KCC2A_HUMANNMDE1_HUMANkinase -> substrateHPRD
KPCA_HUMANNMDE1_HUMANkinase -> substrateHPRD
KCC2B_HUMANNMDE1_HUMANkinase -> substrateHPRD
SRC_HUMANNMDE1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05033Nicotine addiction
hsa05010Alzheimer's disease
hsa05030Cocaine addiction
hsa04728Dopaminergic synapse
hsa05034Alcoholism
hsa05322Systemic lupus erythematosus
hsa04080Neuroactive ligand-receptor interaction
hsa05031Amphetamine addiction
hsa04724Glutamatergic synapse
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa04020Calcium signaling pathway
hsa04720Long-term potentiation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045211postsynaptic membraneIEAcellular_component
GO:0030054cell junctionIEAcellular_component
GO:0001964startle responseIEAbiological_process
GO:0014069postsynaptic densityIEAcellular_component
GO:0017146N-methyl-D-aspartate selective glutamate receptor IEAcellular_component
GO:0042493response to drugIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0060078regulation of postsynaptic membrane potentialIEAbiological_process
GO:0060079regulation of excitatory postsynaptic membrane potIEAbiological_process
GO:0007612learningIEAbiological_process
GO:0001975response to amphetamineIEAbiological_process
GO:0007268synaptic transmissionIEAbiological_process
GO:0007611learning or memoryTASbiological_process
GO:0006816calcium ion transportIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0019233sensory perception of painIEAbiological_process
GO:0048167regulation of synaptic plasticityIEAbiological_process
GO:0008104protein localizationIEAbiological_process
GO:0006810transportTASbiological_process
GO:0007613memoryIEAbiological_process
GO:0033058directional locomotionIEAbiological_process
GO:0042391regulation of membrane potentialIEAbiological_process
GO:0005234extracellular-glutamate-gated ion channel activityIEAmolecular_function
GO:0042428serotonin metabolic processIEAbiological_process
GO:0007215glutamate receptor signaling pathwayTASbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0004970ionotropic glutamate receptor activityIEAmolecular_function
GO:0042417dopamine metabolic processIEAbiological_process
GO:0005215transporter activityIEAmolecular_function
GO:0050804regulation of synaptic transmissionIEAbiological_process
GO:0008542visual learningIEAbiological_process
GO:0070588calcium ion transmembrane transportIEAbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0007611learning or memoryIEAbiological_process
GO:0005261cation channel activityIEAmolecular_function
GO:0009611response to woundingIEAbiological_process
GO:0017146N-methyl-D-aspartate selective glutamate receptor IDAcellular_component
GO:0045202synapseIEAcellular_component
GO:0022008neurogenesisIEAbiological_process
GO:0005262calcium channel activityIEAmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0009986cell surfaceIEAcellular_component
GO:0042177negative regulation of protein catabolic processIEAbiological_process
GO:0008270zinc ion bindingISSmolecular_function
GO:0042734presynaptic membraneIEAcellular_component
GO:0030288outer membrane-bounded periplasmic spaceIEAcellular_component
GO:0045471response to ethanolIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016020membraneIEAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0030431sleepIEAbiological_process
GO:0051930regulation of sensory perception of painIEAbiological_process
GO:0040011locomotionIEAbiological_process
GO:0009986cell surfaceISScellular_component
GO:0004972N-methyl-D-aspartate selective glutamate receptor IEAmolecular_function