Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	PLAK_HUMAN
Description:	junction plakoglobin [Source:HGNC Symbol;Acc:6207]
Location:	chr17 q21.2
Node attribute:	substrate; gene

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
Y133	VHLINyQDDAE	FYN	HPRD; RegPhos
Y20	EWQQTyTYDSG		PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y53	ACGRQyTLKKT		PhosphoSitePlus
S664	YRKRVsVELTN		phosphoELM; RegPhos
T141	DAELAtRALPE	HEAT_2; RIX1	PhosphoSitePlus
S77	LEYQMsTTARA		PhosphoSitePlus
Y61	KKTTTyTQGVP		PhosphoSitePlus
Y133	VHLINyQDDAE	HEAT_2; RIX1	PhosphoSitePlus
Y644	EGTATyAAAVL	SRC	HPRD
Y549	GTQQPyTDGVR	FER	RegPhos
T160	DPVVVtKAAMI	HEAT_2; RIX1	PhosphoSitePlus
Y724	DMDGDyPIDTY		PhosphoSitePlus
S120	RLAEPsQLLKS	HEAT_2; RIX1	PhosphoSitePlus
T62	KTTTYtQGVPP		PhosphoSitePlus
T54	CGRQYtLKKTT		PhosphoSitePlus
Y74	QGDLEyQMSTT		PhosphoSitePlus
T60	LKKTTtYTQGV		PhosphoSitePlus
Y549	GTQQPyTDGVR	FYN	RegPhos
Y643	EGTATyAAAVL	SRC	RegPhos
S665	YRKRVsVELTN		PhosphoSitePlus; HPRD; SysPTM
S120	RLAEPsQLLKS		HPRD
S182	RALMGsPQLVA	HEAT_2; RIX1	PhosphoSitePlus; SysPTM
Y550	GTQQPyTDGVR		PhosphoSitePlus
Y22	QQTYTyDSGIH		PhosphoSitePlus; HPRD
Y480	SVRLNyGIPAI		PhosphoSitePlus
T19	TEWQQtYTYDS		PhosphoSitePlus
Y550	GTQQPyTDGVR	FYN	HPRD
T463	ALRHLtSRHPE	RIX1; Atx10homo_assoc; Ar	PhosphoSitePlus
S24	TYTYDsGIHSG		PhosphoSitePlus
Y729	YPIDTySDGLR		PhosphoSitePlus
T728	DYPIDtYSDGL		PhosphoSitePlus
Y701	DMDATyRPMYS		PhosphoSitePlus
Y644	EGTATyAAAVL	Arm	PhosphoSitePlus
S182	RALMGsPQLVA		HPRD; phosphoELM; RegPhos; SysPTM
T551	TQQPYtDGVRM		PhosphoSitePlus
T430	NKTLVtQNSGV	RIX1; Atx10homo_assoc; Ar	PhosphoSitePlus
Y550	GTQQPyTDGVR	FER	HPRD
T196	RTMQNtSDLDT	HEAT_2; RIX1	PhosphoSitePlus
S596	QLLYSsVENIQ	Arm	PhosphoSitePlus
T59	TLKKTtTYTQG		PhosphoSitePlus
S68	QGVPPsQGDLE		PhosphoSitePlus
Y660	DKNPDyRKRVS		PhosphoSitePlus; HPRD
T21	WQQTYtYDSGI		PhosphoSitePlus
T564	IVEGCtGALHI		PhosphoSitePlus
T58	YTLKKtTTYTQ		PhosphoSitePlus

Dephosphorylation site

PLAK_HUMAN do not have dephosphorylation site.

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000377507	P238S	Ding2008, COSMIC	Lung Cancer	18948947
ENSP00000377507	R203C	Ding2008, COSMIC	Lung Cancer	18948947
ENSP00000377508	L415H	COSMIC	Ovarian Cancer	21720365
ENSP00000311113	P238S	Ding2008, COSMIC	Lung Cancer	18948947
ENSP00000311113	R203C	Ding2008, COSMIC	Lung Cancer	18948947
ENSP00000377507	L415H	COSMIC	Ovarian Cancer	21720365
ENSP00000377507	N490S	COSMIC	Ovarian Cancer	21720365
ENSP00000311113	L415H	COSMIC	Ovarian Cancer	21720365
ENSP00000311113	N490S	COSMIC	Ovarian Cancer	21720365
ENSP00000377508	R203C	Ding2008, COSMIC	Lung Cancer	18948947
ENSP00000377508	P238S	Ding2008, COSMIC	Lung Cancer	18948947
ENSP00000377508	N490S	COSMIC	Ovarian Cancer	21720365

Differential expressed protein

Ensembl ID	Cancer name	Design	Sample	Change	Ratio	Pubmed
ENSP00000377508	Uterine Cancer	Normal vs. Cancer	tissue	Down		17902640
ENSP00000377508	Gastric Cancer	Normal vs. Cancer	tissue	Up	2.2	19330469
ENSP00000377508	Ovarian Cancer	Treatment (chemotherapy-sensitive vs. chemotherapy-resistant)	tissue	Down	0.47	19422301

Hyperphosphorylation site

PLAK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
ZAGL2_HUMAN	PLAK_HUMAN	kinase -> substrate	RegPhos
SRC_HUMAN	PLAK_HUMAN	kinase -> substrate	HPRD; RegPhos
FYN_HUMAN	PLAK_HUMAN	kinase -> substrate	RegPhos
FER_HUMAN	PLAK_HUMAN	kinase -> substrate	HPRD; RegPhos
GLI1_HUMAN	PLAK_HUMAN	TF -> target gene	TRANSFAC

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa05202	Transcriptional misregulation in cancer
hsa05200	Pathways in cancer
hsa05221	Acute myeloid leukemia
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (A

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0051291	protein heterooligomerization	IEA	biological_process
GO:0016477	cell migration	IMP	biological_process
GO:0071603	endothelial cell-cell adhesion	ISS	biological_process
GO:0071665	gamma-catenin-TCF7L2 complex	IDA	cellular_component
GO:0005515	protein binding	IEA	molecular_function
GO:0005916	fascia adherens	IEA	cellular_component
GO:0034329	cell junction assembly	TAS	biological_process
GO:0000902	cell morphogenesis	IBA	biological_process
GO:0007016	cytoskeletal anchoring at plasma membrane	IBA	biological_process
GO:0005737	cytoplasm	IEA	cellular_component
GO:0014704	intercalated disc	IDA	cellular_component
GO:0050982	detection of mechanical stimulus	IDA	biological_process
GO:0032993	protein-DNA complex	IDA	cellular_component
GO:0005199	structural constituent of cell wall	IC	molecular_function
GO:0005882	intermediate filament	IEA	cellular_component
GO:0003308	negative regulation of Wnt receptor signaling path	IBA	biological_process
GO:0016328	lateral plasma membrane	IEA	cellular_component
GO:0005829	cytosol	IEA	cellular_component
GO:0086005	regulation of ventricular cardiac muscle cell acti	IMP	biological_process
GO:0086069	bundle of His cell to Purkinje myocyte communicati	IMP	biological_process
GO:0042307	positive regulation of protein import into nucleus	IDA	biological_process
GO:0005913	cell-cell adherens junction	IDA	cellular_component
GO:0009898	internal side of plasma membrane	IEA	cellular_component
GO:0005634	nucleus	IMP	cellular_component
GO:0090263	positive regulation of canonical Wnt receptor sign	IC	biological_process
GO:0030018	Z disc	IEA	cellular_component
GO:0042127	regulation of cell proliferation	IDA	biological_process
GO:0002159	desmosome assembly	IEA	biological_process
GO:0034332	adherens junction organization	TAS	biological_process
GO:0003181	atrioventricular valve morphogenesis	IBA	biological_process
GO:0005737	cytoplasm	IMP	cellular_component
GO:0005913	cell-cell adherens junction	IEA	cellular_component
GO:0005911	cell-cell junction	IDA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016323	basolateral plasma membrane	IBA	cellular_component
GO:0045296	cadherin binding	IPI	molecular_function
GO:0003713	transcription coactivator activity	IDA	molecular_function
GO:0005488	binding	IEA	molecular_function
GO:0048599	oocyte development	IBA	biological_process
GO:0007398	ectoderm development	IBA	biological_process
GO:0071681	cellular response to indole-3-methanol	IDA	biological_process
GO:0005198	structural molecule activity	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0016331	morphogenesis of embryonic epithelium	IBA	biological_process
GO:0051091	positive regulation of sequence-specific DNA bindi	IDA	biological_process
GO:0016342	catenin complex	IDA	cellular_component
GO:0015629	actin cytoskeleton	IBA	cellular_component
GO:0016327	apicolateral plasma membrane	IEA	cellular_component
GO:0043588	skin development	IEA	biological_process
GO:0005911	cell-cell junction	IEA	cellular_component
GO:0045216	cell-cell junction organization	TAS	biological_process
GO:0042981	regulation of apoptotic process	IDA	biological_process
GO:0005856	cytoskeleton	ISS	cellular_component
GO:0007369	gastrulation	IBA	biological_process
GO:0005886	plasma membrane	IDA	cellular_component
GO:0007399	nervous system development	IBA	biological_process
GO:0005915	zonula adherens	ISS	cellular_component
GO:0019903	protein phosphatase binding	IPI	molecular_function
GO:0007155	cell adhesion	IEA	biological_process
GO:0030057	desmosome	IEA	cellular_component
GO:0003136	negative regulation of heart induction by canonica	IBA	biological_process
GO:0016337	cell-cell adhesion	IEA	biological_process
GO:0045294	alpha-catenin binding	IEA	molecular_function
GO:0019901	protein kinase binding	IEA	molecular_function
GO:0042803	protein homodimerization activity	ISS	molecular_function
GO:0086091	regulation of heart rate by cardiac conduction	IMP	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network