Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DYN1_HUMAN
Description:dynamin 1 [Source:HGNC Symbol;Acc:2972]
Location:chr9 q34.11
Node attribute:effector; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y231PLRRGyIGVVNSRCHPRD; RegPhos
S778RSPTSsPTPQRPhosphoSitePlus; phosphoELM
S795PARPGsRGPAPPRKCAHPRD
Y354DQIDTyELSGGRegPhos
S778RSPTSsPTPQRCDK5HPRD; RegPhos
S777RRSPTsSPTPQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S437ISELIsTVRQCDynamin_MPhosphoSitePlus
S857PSRPEsPRPPFDYRK1AphosphoELM; RegPhos
T411DMAFEtIVKKQDynamin_MPhosphoSitePlus; SysPTM
S795PARPGsRGPAPPhosphoSitePlus
S774PAGRRsPTSSPCDK_groupphosphoELM; RegPhos
S851RSGQAsPSRPEPhosphoSitePlus
S347KRIEGsGDQIDDynamin_MPhosphoSitePlus
T443TVRQCtKKLQQDynamin_MPhosphoSitePlus
S778RSPTSsPTPQRCDK_groupphosphoELM; RegPhos
T776GRRSPtSSPTPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S774PAGRRsPTSSPPhosphoSitePlus; phosphoELM
S795PARPGsRGPAPPKCaRegPhos
S512NKKKTsGNQDEPhosphoSitePlus
Y597EQRNVyKDYRQSRCHPRD; RegPhos
T411DMAFEtIVKKQHPRD; SysPTM
Y125INLRVySPHVLRegPhos
T780PTSSPtPQRRAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S857PSRPEsPRPPFPhosphoSitePlus
T438SELIStVRQCTDynamin_MPhosphoSitePlus
Y732EMLRMyHALKEGEDPhosphoSitePlus
S822SRPGAsPDPFGPhosphoSitePlus
Y80NATTEyAEFLHRegPhos
S774PAGRRsPTSSPCDK5HPRD; RegPhos
Y354DQIDTyELSGGDynamin_MPhosphoSitePlus

Dephosphorylation site
DYN1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000362014R724QCOSMICOvarian Cancer21720365
ENSP00000345680R724QTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
DYN1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DYN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG8_HUMANDYN1_HUMANGprotein -> effectorgpDB
GBG10_HUMANDYN1_HUMANGprotein -> effectorgpDB
GBG3_HUMANDYN1_HUMANGprotein -> effectorgpDB
GBG5_HUMANDYN1_HUMANGprotein -> effectorgpDB
GBB5_HUMANDYN1_HUMANGprotein -> effectorgpDB
GBG1_HUMANDYN1_HUMANGprotein -> effectorgpDB
GBB2_HUMANDYN1_HUMANGprotein -> effectorgpDB
GBG2_HUMANDYN1_HUMANGprotein -> effectorgpDB
GBG13_HUMANDYN1_HUMANGprotein -> effectorgpDB
GBB1_HUMANDYN1_HUMANGprotein -> effectorgpDB
GBB3_HUMANDYN1_HUMANGprotein -> effectorgpDB
GBG12_HUMANDYN1_HUMANGprotein -> effectorgpDB
GBG11_HUMANDYN1_HUMANGprotein -> effectorgpDB
ZAGL2_HUMANDYN1_HUMANkinase -> substrateRegPhos
SRC_HUMANDYN1_HUMANkinase -> substrateRegPhos
CDK5_HUMANDYN1_HUMANkinase -> substrateRegPhos
DYR1A_HUMANDYN1_HUMANkinase -> substrateRegPhos
KPCA_HUMANDYN1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04144Endocytosis
hsa05100Bacterial invasion of epithelial cells
hsa04961Endocrine and other factor-regulated calcium reabs
hsa04721Synaptic vesicle cycle

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031623receptor internalizationIEAbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0006897endocytosisIMPbiological_process
GO:0006898receptor-mediated endocytosisIMPbiological_process
GO:0006898receptor-mediated endocytosisIEAbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0006184GTP catabolic processTASbiological_process
GO:0030117membrane coatIEAcellular_component
GO:0043234protein complexIEAcellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0005543phospholipid bindingIEAmolecular_function
GO:0007032endosome organizationIMPbiological_process
GO:0005874microtubuleIEAcellular_component
GO:0008022protein C-terminus bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0032403protein complex bindingIEAmolecular_function


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