Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KPCI_HUMAN
Description:protein kinase C, iota [Source:HGNC Symbol;Acc:9404]
Location:chr3 q26.2
Node attribute:PPI(target); substrate; kinase; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S402PGDTTsTFCGTphosphoELM
S11DSSTMsHTVAGPhosphoSitePlus; HPRD
S7TMSHHPRD
S591NPLLMsAEECVPhosphoSitePlus
S591NPLLMsAEEHPRD
T564EPVQLtPDDDDHPRD
S226PSSHEsLDQVGPhosphoSitePlus
S222IPYNPsSHESLPhosphoSitePlus
T3RDSSHPRD
T400LRPGDtTSTFCphosphoELM
Y430LRGEDyGFSVDPkinasePhosphoSitePlus
T410RPGDTtSTFCGHPRD
S247SGKASsSLGLQPhosphoSitePlus
T564EPVQLtPDDDDPkinase_CPhosphoSitePlus
S411PGDTTsTFCGTPkinasePhosphoSitePlus
T403GDTTStFCGTPphosphoELM; RegPhos
S44THFEPsISFEGPB1PhosphoSitePlus
S8TQRDSsTMSHTPhosphoSitePlus; HPRD
T416STFCGtPNYIAPkinasePhosphoSitePlus
T416STFCGtPNYIAHPRD
S7PTQRDsSTMSHPhosphoSitePlus
Y397IKLTDyGMCKEPkinasePhosphoSitePlus
T410RPGDTtSTFCGPkinasePhosphoSitePlus
T555EPVQLtPDDDDRegPhos
T412GDTTStFCGTPHPRD
S459DIVGSsDNPDQPkinasePhosphoSitePlus
S223PYNPSsHESLDPhosphoSitePlus
T409LRPGDtTSTFCPkinasePhosphoSitePlus
S411PGDTTsTFCGTHPRD
Y265IGRGSyAKVLLSRCHPRD
Y256IGRGSyAKVLLSrcRegPhos
Y136RWRKLyCANGHPhosphoSitePlus
Y325FFVIEyVNGGDSRCphosphoELM; RegPhos
S459DIVGSsDNPDQHPRD
T13STMSHtVAGGGPhosphoSitePlus; HPRD
T9QRDSStMSHTVPhosphoSitePlus; HPRD
Y256IGRGSyAKVLLSRCphosphoELM; RegPhos
Y334FFVIEyVNGGDSRCHPRD
T3___MPtQRDSSPhosphoSitePlus
Y325FFVIEyVNGGDSrcRegPhos
S46FEPSIsFEGLCPB1PhosphoSitePlus
T401RPGDTtSTFCGphosphoELM
Y584FEGFEyINPLLPkinase_CPhosphoSitePlus
Y280KTDRIyAMKVVSRCHPRD
Y125EDKSIyRRGARPhosphoSitePlus
Y271KTDRIyAMKVVSRCphosphoELM; RegPhos
S246ESGKAsSSLGLPhosphoSitePlus
T412GDTTStFCGTPPkinasePhosphoSitePlus
S19VAGGGsGDHSHPhosphoSitePlus; HPRD
T409LRPGDtTSTFCHPRD
Y271KTDRIyAMKVVSrcRegPhos

Dephosphorylation site
KPCI_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000295797D121HBIOMARTBreast Cancer21930507, 21930502
ENSP00000295797R480CTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
KPCI_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KPCI_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCI_HUMANBMX_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANRGCC_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANKPCI_HUMANkinase -> substrateRegPhos
KPCI_HUMANKS6B2_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANPIR_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANNUCL_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANMLX_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANETS1_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANL2GL2_HUMANkinase -> substrateKEGG
KPCI_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANANXA1_HUMANkinase -> substrateHPRD
KPCI_HUMANENOA_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
SRC_HUMANKPCI_HUMANkinase -> substrateRegPhos
KPCI_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANAFAD_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANPARD3_HUMANkinase -> substrateKEGG
KPCI_HUMANCSDC2_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANSRSF2_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANNRIP2_HUMANkinase -> substrateRobert H Newman (2013)
PP2AA_HUMANKPCI_HUMANphosphatase -> substrateKEGG
KPCI_HUMANGTR4_HUMANotherKEGG
PI3R5_HUMANKPCI_HUMANotherKEGG
KPCI_HUMANSRBP1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway
hsa04144Endocytosis
hsa04530Tight junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016324apical plasma membraneIEAcellular_component
GO:0006612protein targeting to membraneNASbiological_process
GO:0043234protein complexIEAcellular_component
GO:0042462eye photoreceptor cell developmentIEAbiological_process
GO:0045197establishment or maintenance of epithelial cell apTASbiological_process
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0004697protein kinase C activityISSmolecular_function
GO:0034351negative regulation of glial cell apoptotic procesIMPbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0045216cell-cell junction organizationIMPbiological_process
GO:0060252positive regulation of glial cell proliferationIMPbiological_process
GO:0005543phospholipid bindingIDAmolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0005768endosomeIEAcellular_component
GO:0046326positive regulation of glucose importISSbiological_process
GO:0090004positive regulation of establishment of protein loIEAbiological_process
GO:0000133polarisomeTAScellular_component
GO:0007010cytoskeleton organizationNASbiological_process
GO:0046903secretionNASbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0010976positive regulation of neuron projection developmeIMPbiological_process
GO:0048194Golgi vesicle buddingIEAbiological_process
GO:0070830tight junction assemblyTASbiological_process
GO:2000353positive regulation of endothelial cell apoptotic IMPbiological_process
GO:0090004positive regulation of establishment of protein loISSbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005829cytosolIDAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0004697protein kinase C activityIEAmolecular_function
GO:0043524negative regulation of neuron apoptotic processIDAbiological_process
GO:0046326positive regulation of glucose importIEAbiological_process
GO:0016477cell migrationIEAbiological_process
GO:0034613cellular protein localizationIEAbiological_process
GO:0005524ATP bindingTASmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0035089establishment of apical/basal cell polarityIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0070555response to interleukin-1IEAbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0031252cell leading edgeIEAcellular_component
GO:0032869cellular response to insulin stimulusISSbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0016044cellular membrane organizationNASbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0045177apical part of cellIEAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0043220Schmidt-Lanterman incisureIEAcellular_component
GO:0007015actin filament organizationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0016192vesicle-mediated transportTASbiological_process
GO:0034329cell junction assemblyTASbiological_process
GO:0032869cellular response to insulin stimulusIEAbiological_process
GO:0006468protein phosphorylationIDAbiological_process