Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BCAR1_HUMAN
Description:breast cancer anti-estrogen resistance 1 [Source:HGNC Symbol;Acc:971]
Location:chr16 q23.1
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y262LLPSQyGQEVYPhosphoSitePlus
Y387GPGTLyDVPRESRCHPRD; RegPhos
Y327LREETyDVPPAFGFR1phosphoELM; RegPhos
Y664GWMEDyDYVHLphosphoELM; RegPhos
Y165PATDLyQVPPGSRCHPRD; RegPhos
Y815SQVTHySNLLCDUF3513PhosphoSitePlus
S134QVPGPsPQFQSPhosphoSitePlus; HPRD; phosphoELM
Y362PAEDVyDVPPPSRCHPRD; RegPhos
Y128AQQGLyQVPGPFGFR1phosphoELM; RegPhos
Y362PAEDVyDVPPPPhosphoSitePlus; RegPhos
Y664GWMEDyDYVHLDUF3513PhosphoSitePlus
Y115QPDSVyLVPTPPhosphoSitePlus
Y664GWMEDyDYVHLPTK2HPRD
S313VPPSVsKDVPDPhosphoSitePlus
Y386PGPGTlYDVPRHPRD
Y653SPDGQyENSEGphosphoELM
S139SPQFQsPPAKQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y653SPDGQyENSEGDUF3513PhosphoSitePlus
S431RLSASsTGSTRPhosphoSitePlus
Y12LAKALyDNVAESH3_1PhosphoSitePlus
Y326LLREEtYDVPPHPRD
S300KGLPPsNHHAVPhosphoSitePlus
Y67ILVGMyDKKPAPhosphoSitePlus
Y306NHHAVyDVPPSFGFR1phosphoELM; RegPhos
Y287PLLEVyDVPPSPhosphoSitePlus
Y664GWMEDyDYVHLFAKRegPhos
Y165PATDLyQVPPGPhosphoSitePlus; phosphoELM; RegPhos
Y653SPDGQyENSEGSRCHPRD; phosphoELM; RegPhos
Y306NHHAVyDVPPSPhosphoSitePlus; HPRD; RegPhos
S260RGLLPsQYGQEPhosphoSitePlus
Y653SPDGQyENSEGSrcRegPhos
Y267YGQEVyDTPPMSRCHPRD; RegPhos
Y410VDSGVyAVPPPFGFR1phosphoELM; RegPhos
Y287PLLEVyDVPPSSRCHPRD; RegPhos
S428EGKRLsASSTGPhosphoSitePlus; HPRD
S292YDVPPsVEKGLPhosphoSitePlus; HPRD; phosphoELM
T435SSTGStRSSQSPhosphoSitePlus
S355APPPDsPPAEDPhosphoSitePlus
Y249GPQDIyDVPPVFGFR1phosphoELM; RegPhos; SysPTM
T385RPGPGtLYDVPPhosphoSitePlus
S639SRPLPsPPKFTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T326LLREEtYDVPPPhosphoSitePlus
S311YDVPPsVSKDVPhosphoSitePlus
Y387GPGTLyDVPREPhosphoSitePlus; phosphoELM; RegPhos
Y128AQQGLyQVPGPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y327LREETyDVPPAPhosphoSitePlus; HPRD; RegPhos
Y234PEQDEyDIPRHSRCHPRD; RegPhos
Y249GPQDIyDVPPVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y267YGQEVyDTPPMPhosphoSitePlus
S407GGVVDsGVYAVPhosphoSitePlus
S437TGSTRsSQSASPhosphoSitePlus
Y234PEQDEyDIPRHPhosphoSitePlus; phosphoELM; RegPhos
T432LSASStGSTRSPhosphoSitePlus
Y666MEDYDyVHLQGDUF3513PhosphoSitePlus
Y115QPDSVyLVPTPSRCHPRD; RegPhos
Y179PAQDIyQVPPSSRCHPRD; RegPhos
Y666MEDYDyVHLQGPTK2HPRD
Y222RVGQGyVYEAAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y224GQGYVyEAAQPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T269QEVYDtPPMAVPhosphoSitePlus; HPRD; phosphoELM
Y666MEDYDyVHLQGFAKRegPhos
Y410VDSGVyAVPPPPhosphoSitePlus; HPRD; RegPhos
Y192MGHDIyQVPPSSRCHPRD; RegPhos
Y372PAPDLyDVPPGPhosphoSitePlus; HPRD
S184YQVPPsAGMGHPhosphoSitePlus
Y179PAQDIyQVPPSPhosphoSitePlus
Y192MGHDIyQVPPSPhosphoSitePlus
S694TRQGKsQLELQDUF3513PhosphoSitePlus

Dephosphorylation site
BCAR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000162330S407TSjoblom2006, COSMIC, HPIBreast Cancer16959974, 18428421
ENSP00000162330A780VCOSMICCentral Nervous System Neoplasms18772890
ENSP00000162330E708KCOSMICCentral Nervous System Neoplasms18772890
ENSP00000162330Q592HCOSMICHepatocellular Carcinoma21822264

Differential expressed protein
BCAR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BCAR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FAK1_HUMANBCAR1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANBCAR1_HUMANkinase -> substrateRegPhos
LYN_HUMANBCAR1_HUMANkinase -> substrateNetPath
SRC_HUMANBCAR1_HUMANkinase -> substrateRegPhos
FGFR1_HUMANBCAR1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
BCAR1_HUMANCRK_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05100Bacterial invasion of epithelial cells
hsa04810Regulation of actin cytoskeleton
hsa04062Chemokine signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04510Focal adhesion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007155cell adhesionIEAbiological_process
GO:0010595positive regulation of endothelial cell migrationIDAbiological_process
GO:0001558regulation of cell growthTASbiological_process
GO:0050852T cell receptor signaling pathwayNASbiological_process
GO:0035729cellular response to hepatocyte growth factor stimIMPbiological_process
GO:0030168platelet activationTASbiological_process
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0007229integrin-mediated signaling pathwayIDAbiological_process
GO:0048008platelet-derived growth factor receptor signaling IEAbiological_process
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0016477cell migrationIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0007173epidermal growth factor receptor signaling pathwayISSbiological_process
GO:0048011nerve growth factor receptor signaling pathwayISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007015actin filament organizationIDAbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0008286insulin receptor signaling pathwayISSbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0030027lamellipodiumIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0001726ruffleIDAcellular_component
GO:0051301cell divisionNASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0042981regulation of apoptotic processTASbiological_process
GO:0050853B cell receptor signaling pathwayIDAbiological_process
GO:0048010vascular endothelial growth factor receptor signalIMPbiological_process
GO:0004871signal transducer activityTASmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0048012hepatocyte growth factor receptor signaling pathwaIMPbiological_process
GO:0060326cell chemotaxisIMPbiological_process
GO:0050851antigen receptor-mediated signaling pathwayIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0005925focal adhesionISScellular_component


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23