Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ITB1_HUMAN
Description:integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [Source:HGNC Symbol;Acc:6153]
Location:chr10 p11.22
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y147PIDLYyLMDLSIntegrin_betaPhosphoSitePlus
S224YKNVLsLTNKGIntegrin_betaPhosphoSitePlus
T130SGEPQtFTLKFIntegrin_betaPhosphoSitePlus
T777NAKWDtGENPIHPRD
S197VMPYIsTTPAKIntegrin_betaPhosphoSitePlus
T226NVLSLtNKGEVHPRD
S785NPIYKsAVTTVIntegrin_b_cytPhosphoSitePlus
Y141KRAEDyPIDLYIntegrin_betaPhosphoSitePlus
Y783GENPIyKSAVTHPRD; phosphoELM; SysPTM
Y783GENPIyKSAVTIntegrin_b_cytPhosphoSitePlus; SysPTM
S224YKNVLsLTNKGHPRD
T788YKSAVtTVVNPIntegrin_b_cytPhosphoSitePlus
T789KSAVTtVVNPKphosphoELM
T789KSAVTtVVNPKIntegrin_b_cytPhosphoSitePlus
Y782TGENPiYKSAVHPRD
T788YKSAVtTVVNPphosphoELM
S327LVQKLsENNIQHPRD
Y783QENPIyKSPINHPRD; SysPTM
T333ENNIQtIFAVTHPRD
Y795VVNPKyEGK__Integrin_b_cytPhosphoSitePlus
T777NAKWDtGENPIIntegrin_b_cytPhosphoSitePlus
T226NVLSLtNKGEVIntegrin_betaPhosphoSitePlus
S785NPIYKsAVTTVHPRD

Dephosphorylation site
ITB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000364094R495CBIOMARTBreast Cancer21930507, 21930502
ENSP00000379350R495CBIOMARTBreast Cancer21930507, 21930502
ENSP00000303351R495CBIOMARTBreast Cancer21930507, 21930502
ENSP00000388694R495CBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000379350Pancreatic CancerNormal vs. CancertissueUp3.416215274
ENSP00000379350Esophageal CancerNormal vs. CancertissueDown0.3619142970
ENSP00000379350Esophageal CancerNormal vs. CancertissueDown0.3719142970
ENSP00000379350Esophageal CancerNormal vs. CancertissueDown0.4119142970
ENSP00000379350Breast CancerTreatment (mitoxantrone-sensitive vs. mitoxantrone-resistant)cell lineDown0.316335961
ENSP00000379350Hepatocellular CarcinomaNormal vs. Cancercell lineUp6.219120023
ENSP00000379350Breast CancerMetastasiscell lineUp1118729497
ENSP00000379350Breast CancerMetastasiscell lineUp2.0-5.119321434
ENSP00000379350Breast CancerCancer vs. Cancer (Non-TNBC vs. TNBC)cell lineUp20596302
ENSP00000379350Pancreatic CancerNormal vs. CancertissueUp2.716230073

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y783Integrin_b_cytDTGENPIyKSAVTTVcholangiocellular carcinoma21253578PhosphoSitePlus
Y795Integrin_b_cytTTVVNPKyEGK____cholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ITB1_HUMANFAK1_HUMANotherKEGG
ITB1_HUMANSRC_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05130Pathogenic Escherichia coli infection
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa04512ECM-receptor interaction
hsa05145Toxoplasmosis
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05200Pathways in cancer
hsa05222Small cell lung cancer
hsa04810Regulation of actin cytoskeleton
hsa05131Shigellosis
hsa04145Phagosome
hsa04670Leukocyte transendothelial migration
hsa04360Axon guidance
hsa05133Pertussis
hsa05140Leishmaniasis
hsa04514Cell adhesion molecules (CAMs)
hsa05100Bacterial invasion of epithelial cells
hsa04510Focal adhesion
hsa05414Dilated cardiomyopathy

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001894tissue homeostasisIEAbiological_process
GO:0007161calcium-independent cell-matrix adhesionIGIbiological_process
GO:0031345negative regulation of cell projection organizatioIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0004872receptor activityIEAmolecular_function
GO:0071260cellular response to mechanical stimulusIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0008277regulation of G-protein coupled receptor protein sIEAbiological_process
GO:0031594neuromuscular junctionIEAcellular_component
GO:0005911cell-cell junctionIEAcellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0000082G1/S transition of mitotic cell cycleIEAbiological_process
GO:0035748myelin sheath abaxonal regionIEAcellular_component
GO:0030056hemidesmosomeIEAcellular_component
GO:0001669acrosomal vesicleIEAcellular_component
GO:0014823response to activityIEAbiological_process
GO:0010976positive regulation of neuron projection developmeIEAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0034667alpha3-beta1 integrin complexIEAcellular_component
GO:0031667response to nutrient levelsIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0007160cell-matrix adhesionIEAbiological_process
GO:0006968cellular defense responseTASbiological_process
GO:0001708cell fate specificationIEAbiological_process
GO:0050776regulation of immune responseTASbiological_process
GO:0033631cell-cell adhesion mediated by integrinIEPbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0007159leukocyte cell-cell adhesionIDAbiological_process
GO:0014704intercalated discIEAcellular_component
GO:0016477cell migrationTASbiological_process
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0001726ruffleTAScellular_component
GO:0002020protease bindingIEAmolecular_function
GO:0043065positive regulation of apoptotic processIGIbiological_process
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0042383sarcolemmaIEAcellular_component
GO:0010811positive regulation of cell-substrate adhesionIEAbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0005925focal adhesionIEAcellular_component
GO:0032154cleavage furrowIEAcellular_component
GO:0019900kinase bindingIEAmolecular_function
GO:2000811negative regulation of anoikisIMPbiological_process
GO:0034679alpha9-beta1 integrin complexIEAcellular_component
GO:0071559response to transforming growth factor beta stimulIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0002042cell migration involved in sprouting angiogenesisIEAbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0030175filopodiumIDAcellular_component
GO:0034329cell junction assemblyTASbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0005604basement membraneIEAcellular_component
GO:0001948glycoprotein bindingIEAmolecular_function
GO:0042277peptide bindingIEAmolecular_function
GO:0009897external side of plasma membraneIEAcellular_component
GO:0060135maternal process involved in female pregnancyIEAbiological_process
GO:0030183B cell differentiationICbiological_process
GO:0045202synapseIEAcellular_component
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIEAbiological_process
GO:0032594protein transport within lipid bilayerIEAbiological_process
GO:0005178integrin bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0071305cellular response to vitamin DIEAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0034698response to gonadotropin stimulusIEAbiological_process
GO:0070830tight junction assemblyIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0045807positive regulation of endocytosisIEAbiological_process
GO:0034678alpha8-beta1 integrin complexTAScellular_component
GO:0007411axon guidanceTASbiological_process
GO:0042493response to drugIEAbiological_process
GO:0005518collagen bindingIEAmolecular_function
GO:0007229integrin-mediated signaling pathwayIEAbiological_process
GO:0032587ruffle membraneIDAcellular_component
GO:0007156homophilic cell adhesionTASbiological_process
GO:0008305integrin complexNAScellular_component
GO:0051726regulation of cell cycleIEAbiological_process
GO:0055007cardiac muscle cell differentiationIEAbiological_process
GO:0046982protein heterodimerization activityNASmolecular_function
GO:0003779actin bindingIEAmolecular_function
GO:0009986cell surfaceIEAcellular_component
GO:0045214sarcomere organizationIEAbiological_process
GO:0043236laminin bindingIEAmolecular_function
GO:0051393alpha-actinin bindingIEAmolecular_function
GO:0008354germ cell migrationIEAbiological_process
GO:0045596negative regulation of cell differentiationIEAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0071479cellular response to ionizing radiationIEAbiological_process
GO:0031175neuron projection developmentIEAbiological_process
GO:0042470melanosomeIEAcellular_component
GO:0005912adherens junctionIEAcellular_component
GO:0009986cell surfaceIDAcellular_component
GO:0016020membraneIEAcellular_component
GO:0001968fibronectin bindingIEAmolecular_function
GO:0005102receptor bindingIEAmolecular_function
GO:0045665negative regulation of neuron differentiationIEAbiological_process