Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TXK_HUMAN
Description:TXK tyrosine kinase [Source:HGNC Symbol;Acc:12434]
Location:chr4 p12
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y420VLDDEyVSSFGphosphoELM; RegPhos
Y91QVKALyDFLPRRegPhos
Y420VLDDEyVSSFGSRCHPRD; RegPhos
Y91QVKALyDFLPRSH3_1PhosphoSitePlus
Y91QVKALyDFLPRTXKHPRD; phosphoELM; RegPhos
Y420VLDDEyVSSFGautocatalysisRegPhos
Y420VLDDEyVSSFGPkinase_TyrPhosphoSitePlus
Y420VLDDEyVSSFGFYNHPRD; RegPhos

Dephosphorylation site
TXK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264316A216TBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
TXK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TXK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FYN_HUMANTXK_HUMANkinase -> substrateHPRD; RegPhos; NetPath
ZAGL2_HUMANTXK_HUMANkinase -> substrateRegPhos
TXK_HUMANTXK_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANTXK_HUMANkinase -> substrateHPRD; RegPhos
TXK_HUMANLCP2_HUMANkinase -> substrateRegPhos
TXK_HUMANCTLA4_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04670Leukocyte transendothelial migration

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032729positive regulation of interferon-gamma productionIDAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0032633interleukin-4 productionIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0060335positive regulation of interferon-gamma-mediated sIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0050852T cell receptor signaling pathwayISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0001865NK T cell differentiationIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0002250adaptive immune responseISSbiological_process
GO:0001816cytokine productionISSbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0007202activation of phospholipase C activityISSbiological_process
GO:0032609interferon-gamma productionIEAbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0001012RNA polymerase II regulatory region DNA bindingIDAmolecular_function


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