Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HNF1A_HUMAN
Description:HNF1 homeobox A [Source:HGNC Symbol;Acc:11621]
Location:chr12 q24.31
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S249RGVSPsQAQGLPhosphoSitePlus
T74GSEDEtDDDGERegPhos
S70GETRGsEDETDHNF-1_NPhosphoSitePlus
S247IQRGVsPSQAQPhosphoSitePlus
S249RGVSPsQAQGLDYRK1BphosphoELM; RegPhos
T67NGLGEtRGSEDHNF-1_NPhosphoSitePlus
T74GSEDEtDDDGEHNF-1_NPhosphoSitePlus
T82DGEDFtPPILKHNF-1_NPhosphoSitePlus

Dephosphorylation site
HNF1A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000257555R203CCOSMICHepatocellular Carcinoma16496320
ENSP00000257555T260MCOSMICHepatocellular Carcinoma16496320
ENSP00000257555Q250PHPI, COSMICHepatocellular Carcinoma12355088, 17187432
ENSP00000257555R244GCOSMICHepatocellular Carcinoma12355088
ENSP00000257555G207DCOSMICHepatocellular Carcinoma16496320
ENSP00000257555R229*COSMICHepatocellular Carcinoma17187432
ENSP00000257555E66*COSMICHepatocellular Carcinoma16496320
ENSP00000257555G410WBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000257555Q28*COSMICHepatocellular Carcinoma17187432
ENSP00000257555K273ESjoblom2006, COSMICBreast Cancer12355088, 16496320, 16959974, 18428421
ENSP00000257555K273ESjoblom2006Liver Cancer12355088, 16496320, 16959974, 18428421
ENSP00000257555R229GCOSMICHepatocellular Carcinoma16496320
ENSP00000257555Q146fs*9COSMICHepatocellular Carcinoma12355088
ENSP00000257555W165CHPI, COSMICHepatocellular Carcinoma12355088, 17187432
ENSP00000257555R272SCOSMICHepatocellular Carcinoma16496320
ENSP00000257555R263CCOSMICHepatocellular Carcinoma17049664
ENSP00000257555P447LCOSMICHepatocellular Carcinoma16496320
ENSP00000257555L348fs*16COSMICUterine Cancer15326484
ENSP00000257555S574NSjoblom2006, BIOMARTBreast Cancer16959974, 21930507, 21930502, 21720365, 18772890
ENSP00000257555S574NTCGAOvarian Cancer21720365, 18772890
ENSP00000257555P291fs*51COSMICIntestines Cancer12730871
ENSP00000257555V259LCOSMICHepatocellular Carcinoma16496320
ENSP00000257555Q211PCOSMICHepatocellular Carcinoma16496320
ENSP00000257555R168CCOSMICCentral Nervous System Neoplasms21817013
ENSP00000257555Q176*COSMICHepatocellular Carcinoma16496320
ENSP00000257555G319fs*23COSMICHepatocellular Carcinoma16496320
ENSP00000257555F268CCOSMICHepatocellular Carcinoma12355088
ENSP00000257555K155NCOSMICUterine Cancer15326484
ENSP00000257555L26QCOSMICHepatocellular Carcinoma16496320
ENSP00000257555E390*COSMICHepatocellular Carcinoma16496320
ENSP00000257555Q211*COSMICHepatocellular Carcinoma16496320
ENSP00000257555N237SCOSMICHepatocellular Carcinoma16496320
ENSP00000257555E228*COSMICHepatocellular Carcinoma16496320
ENSP00000257555L21fs*1COSMICHepatocellular Carcinoma19762333
ENSP00000257555N127YHPI, COSMICHepatocellular Carcinoma12355088, 17187432
ENSP00000257555R271WCOSMICHepatocellular Carcinoma16496320
ENSP00000257555T457NCOSMICLung Cancer20668451
ENSP00000257555R131WCOSMICHepatocellular Carcinoma16496320
ENSP00000257555Y218CCOSMICHepatocellular Carcinoma16496320
ENSP00000257555W206LCOSMICHepatocellular Carcinoma17187432

Differential expressed protein
HNF1A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HNF1A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANHNF1A_HUMANkinase -> substrateRegPhos
DYR1B_HUMANHNF1A_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
HNF1A_HUMANCRP_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANITA2B_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANALBU_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANHNF4A_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANUDB17_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANCP3A4_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANFIBA_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANFGFR4_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANTHRB_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANAK1C4_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANUD2B7_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANNGN3_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANAPOB_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANSUIS_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANSRC_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANCLD2_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANAPOA2_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANFA8_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANIBP1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04950Maturity onset diabetes of the young

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030073insulin secretionIEAbiological_process
GO:0046323glucose importIEAbiological_process
GO:0003690double-stranded DNA bindingIEAmolecular_function
GO:0015908fatty acid transportIEAbiological_process
GO:0048341paraxial mesoderm formationIEAbiological_process
GO:0046323glucose importIMPbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0001890placenta developmentIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0060395SMAD protein signal transductionIEAbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0015721bile acid and bile salt transportIEAbiological_process
GO:0006338chromatin remodelingIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0008134transcription factor bindingIEAmolecular_function
GO:0035623renal glucose absorptionIEAbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0030326embryonic limb morphogenesisIEAbiological_process
GO:0006979response to oxidative stressIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0046983protein dimerization activityIPImolecular_function
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0008203cholesterol metabolic processIEAbiological_process
GO:0060261positive regulation of transcription initiation frIGIbiological_process
GO:0005634nucleusIDAcellular_component
GO:0001077RNA polymerase II core promoter proximal region seISSmolecular_function
GO:0006699bile acid biosynthetic processIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIDAbiological_process
GO:0030111regulation of Wnt receptor signaling pathwayIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0048608reproductive structure developmentIEAbiological_process
GO:0045453bone resorptionIEAbiological_process
GO:0045120pronucleusIEAcellular_component
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0001889liver developmentIEAbiological_process
GO:0046883regulation of hormone secretionIEAbiological_process
GO:0043234protein complexIDAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0008104protein localizationIEAbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0043691reverse cholesterol transportIEAbiological_process
GO:0001750photoreceptor outer segmentIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0001824blastocyst developmentIEAbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0046983protein dimerization activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0035623renal glucose absorptionIMPbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0042593glucose homeostasisIMPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0050796regulation of insulin secretionIEAbiological_process
GO:0042593glucose homeostasisIEAbiological_process
GO:0006633fatty acid biosynthetic processIEAbiological_process
GO:0031018endocrine pancreas developmentIEAbiological_process
GO:0006783heme biosynthetic processIEAbiological_process
GO:0006366transcription from RNA polymerase II promoterIEAbiological_process