| UniProt/SwissProt ID: | CADH5_HUMAN |
| Description: | cadherin 5, type 2 (vascular endothelium) [Source:HGNC Symbol;Acc:1764] |
| Location: | chr16 q21 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y685 | ARPSLyAQVQK | HPRD; phosphoELM | |
| Y223 | EKQARyEIVVE | Cadherin | PhosphoSitePlus |
| T212 | RIITItKSLDR | Cadherin | PhosphoSitePlus |
| Y731 | DTLHIyGYEGS | SRC | HPRD |
| Y733 | LHIYGyEGSES | Cadherin_C | PhosphoSitePlus |
| S665 | VSVLNsVRRGG | Cadherin_C | PhosphoSitePlus |
| Y725 | GDGPPyDTLHI | Cadherin_C | PhosphoSitePlus |
| Y685 | ARPSLyAQVQK | Cadherin_C | PhosphoSitePlus |
| Y658 | MDTTSyDVSVL | Cadherin_C | PhosphoSitePlus |
| Y784 | REELLy_____ | PhosphoSitePlus | |
| Y774 | MLAELyGSDPR | Cadherin_C | PhosphoSitePlus |
| S683 | LDARPsLYAQV | Cadherin_C | PhosphoSitePlus |
| Y658 | MDTTSyDVSVL | SRC | HPRD |
| Y731 | DTLHIyGYEGS | Cadherin_C | PhosphoSitePlus |
| Dephosphorylation site |
| CADH5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000344115 | V227E | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000344115 | N79T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000344115 | R347* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000344115 | D528N | COSMIC | Melanoma | 21499247 | ENSP00000344115 | H67Q | COSMIC | Lung Cancer | 20668451 | ENSP00000344115 | A31T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000344115 | L518F | COSMIC | Lung Cancer | 20668451 | ENSP00000344115 | N79T | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| CADH5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CADH5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SRC_HUMAN | CADH5_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa04670 | Leukocyte transendothelial migration |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0044325 | ion channel binding | IPI | molecular_function |
| GO:0005923 | tight junction | IEA | cellular_component |
| GO:2000114 | regulation of establishment of cell polarity | IEA | biological_process |
| GO:0005911 | cell-cell junction | IDA | cellular_component |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0045216 | cell-cell junction organization | TAS | biological_process |
| GO:0008285 | negative regulation of cell proliferation | IEA | biological_process |
| GO:0007156 | homophilic cell adhesion | IEA | biological_process |
| GO:0019903 | protein phosphatase binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0008013 | beta-catenin binding | IPI | molecular_function |
| GO:0071944 | cell periphery | IEA | cellular_component |
| GO:0005102 | receptor binding | IPI | molecular_function |
| GO:0001955 | blood vessel maturation | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0034332 | adherens junction organization | TAS | biological_process |
| GO:0034329 | cell junction assembly | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005911 | cell-cell junction | IEA | cellular_component |