Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CADH5_HUMAN
Description:cadherin 5, type 2 (vascular endothelium) [Source:HGNC Symbol;Acc:1764]
Location:chr16 q21
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y685ARPSLyAQVQKHPRD; phosphoELM
Y223EKQARyEIVVECadherinPhosphoSitePlus
T212RIITItKSLDRCadherinPhosphoSitePlus
Y731DTLHIyGYEGSSRCHPRD
Y733LHIYGyEGSESCadherin_CPhosphoSitePlus
S665VSVLNsVRRGGCadherin_CPhosphoSitePlus
Y725GDGPPyDTLHICadherin_CPhosphoSitePlus
Y685ARPSLyAQVQKCadherin_CPhosphoSitePlus
Y658MDTTSyDVSVLCadherin_CPhosphoSitePlus
Y784REELLy_____PhosphoSitePlus
Y774MLAELyGSDPRCadherin_CPhosphoSitePlus
S683LDARPsLYAQVCadherin_CPhosphoSitePlus
Y658MDTTSyDVSVLSRCHPRD
Y731DTLHIyGYEGSCadherin_CPhosphoSitePlus

Dephosphorylation site
CADH5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000344115V227ECOSMICCentral Nervous System Neoplasms18772396
ENSP00000344115N79TCOSMICOvarian Cancer21720365
ENSP00000344115R347*COSMICHead and Neck Cancer21798893
ENSP00000344115D528NCOSMICMelanoma21499247
ENSP00000344115H67QCOSMICLung Cancer20668451
ENSP00000344115A31TCOSMICOvarian Cancer21720365
ENSP00000344115L518FCOSMICLung Cancer20668451
ENSP00000344115N79TTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
CADH5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CADH5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SRC_HUMANCADH5_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04514Cell adhesion molecules (CAMs)
hsa04670Leukocyte transendothelial migration

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0044325ion channel bindingIPImolecular_function
GO:0005923tight junctionIEAcellular_component
GO:2000114regulation of establishment of cell polarityIEAbiological_process
GO:0005911cell-cell junctionIDAcellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0045216cell-cell junction organizationTASbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0007156homophilic cell adhesionIEAbiological_process
GO:0019903protein phosphatase bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0008013beta-catenin bindingIPImolecular_function
GO:0071944cell peripheryIEAcellular_component
GO:0005102receptor bindingIPImolecular_function
GO:0001955blood vessel maturationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0034332adherens junction organizationTASbiological_process
GO:0034329cell junction assemblyTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005911cell-cell junctionIEAcellular_component


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