| UniProt/SwissProt ID: | PTN18_HUMAN |
| Description: | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) [Source:HGNC Symbol;Acc:9649] |
| Location: | chr2 q21.1 |
| Node attribute: | substrate; phosphotase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y389 | EEAPLySKVTP | PhosphoSitePlus; HPRD | |
| Y354 | AMADTyAVVQK | PhosphoSitePlus | |
| T376 | QTGTGtGTGAR | PhosphoSitePlus | |
| T322 | ALFLRtPQALL | PhosphoSitePlus | |
| S390 | EAPLYsKVTPR | PhosphoSitePlus | |
| Y426 | AGSGAyEDVAG | PhosphoSitePlus | |
| T374 | GTQTGtGTGTG | PhosphoSitePlus | |
| Y354 | AMADTyAVVQK | TEC | HPRD |
| T435 | AGGAQtGGLGF | PhosphoSitePlus | |
| Y281 | QTEEQyRFLYH | TEC | HPRD; RegPhos |
| Y354 | AMADTyAEEQK | TEC | RegPhos |
| Y424 | AGSGAyEDVAG | RegPhos | |
| S419 | VPADQsPAGSG | PhosphoSitePlus | |
| T393 | LYSKVtPRAQR | PhosphoSitePlus | |
| S423 | QSPAGsGAYED | PhosphoSitePlus | |
| T458 | PPAEWtRV___ | PhosphoSitePlus | |
| S10 | LDSARsFLERL | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| T370 | GAGSGtQTGTG | PhosphoSitePlus | |
| Y303 | NASPHyQNIKE | TEC | HPRD; RegPhos |
| Y314 | NCAPLyDDALF | PhosphoSitePlus | |
| Y303 | NASPHyQNIKE | PhosphoSitePlus | |
| Y281 | QTEEQyRFLYH | Y_phosphatase | PhosphoSitePlus |
| S345 | ISVPGsPGHAM | PhosphoSitePlus | |
| S76 | TRVILsLLQEE | Y_phosphatase | PhosphoSitePlus |
| Y387 | EEAPLySKVTP | phosphoELM; RegPhos | |
| Dephosphorylation site |
| PTN18_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000175756 | A328P | COSMIC | Renal Cancer | 20054297 | ENSP00000175756 | R331C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000175756 | I74M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000175756 | Y144H | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| PTN18_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PTN18_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TEC_HUMAN | PTN18_HUMAN | kinase -> substrate | RegPhos; NetPath |
| ZAGL2_HUMAN | PTN18_HUMAN | kinase -> substrate | RegPhos |
| PTN18_HUMAN | TEC_HUMAN | phosphatase -> substrate | NetPath |
| PTN18_HUMAN | FYN_HUMAN | phosphatase -> substrate | HPRD |
| PTN18_HUMAN | SRC_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| PTN18_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016311 | dephosphorylation | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0004726 | non-membrane spanning protein tyrosine phosphatase | IEA | molecular_function |
| GO:0006470 | protein dephosphorylation | TAS | biological_process |
| GO:0004725 | protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0016791 | phosphatase activity | IEA | molecular_function |