| UniProt/SwissProt ID: | SPTN1_HUMAN |
| Description: | spectrin, alpha, non-erythrocytic 1 [Source:HGNC Symbol;Acc:11273] |
| Location: | chr9 q34.11 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S2411 | SEEIEsAFRAL | efhand_Ca_insen | PhosphoSitePlus |
| S1031 | PAQSAsRENLL | PhosphoSitePlus; HPRD | |
| S1226 | LAEERsQLLGS | Spectrin | PhosphoSitePlus |
| S1302 | ERLIQsHPESA | Spectrin | PhosphoSitePlus |
| S1029 | LDPAQsASREN | PhosphoSitePlus; HPRD | |
| Y1176 | QQQEVyGMMPR | SRC | HPRD; phosphoELM |
| S1413 | HGHYAsPEIKQ | HPRD | |
| S1615 | IDMGNsLIERG | Spectrin | PhosphoSitePlus |
| T196 | FEEFQtDMAAH | HPRD | |
| S1075 | EELYHsLLELG | HPRD | |
| S553 | RDALLsRRNAL | Spectrin | PhosphoSitePlus |
| T1188 | ETDSKtASPWK | PhosphoSitePlus | |
| Y766 | ALVARyEALKE | Spectrin | PhosphoSitePlus |
| Y1020 | FVPAAyVKKLD | PhosphoSitePlus | |
| S1323 | NQAWSsLGKRA | Spectrin | PhosphoSitePlus |
| Y2423 | SEGKPyVTKEE | efhand_Ca_insen | PhosphoSitePlus |
| S435 | AGHYAsDEVRE | Spectrin | PhosphoSitePlus |
| Y1261 | LNTDNyGHDLA | Spectrin | PhosphoSitePlus |
| Y1411 | LAHGHyASPEI | HPRD | |
| S1159 | AEDLEsEGLMA | Spectrin | PhosphoSitePlus |
| S1186 | RDETDsKTASP | PhosphoSitePlus | |
| Y2430 | TKEELyQNLTR | efhand_Ca_insen | PhosphoSitePlus |
| S1063 | EAGSVsLRMKQ | PhosphoSitePlus | |
| Y601 | ATDEAyKDPSN | Spectrin | PhosphoSitePlus |
| S391 | ADELAsDVAGA | Spectrin | PhosphoSitePlus |
| S1959 | LNGKVsDLEKA | Spectrin | PhosphoSitePlus |
| S1322 | LNQAWsSLGKR | Spectrin | PhosphoSitePlus |
| Y1176 | QQQEVyGMMPR | Lck | phosphoELM |
| T1386 | HQEHRtEIDAR | Spectrin | PhosphoSitePlus |
| Y644 | IDVNHyAKDEV | Spectrin | PhosphoSitePlus |
| T1053 | QIDNQtRITKE | PhosphoSitePlus | |
| Y766 | ALVARyEALKE | HPRD | |
| Y644 | IDVNHyAKDEV | HPRD | |
| S2138 | HDAFRsSLSSA | HPRD | |
| Y2440 | REQADyCVSHM | efhand_Ca_insen | PhosphoSitePlus |
| S944 | LSAYGsSIQAL | Spectrin | PhosphoSitePlus |
| S423 | KSADEsGQALL | Spectrin | PhosphoSitePlus |
| Y1792 | VGSEDyGRDLT | Spectrin | PhosphoSitePlus |
| Y1579 | ASDESyKDPTN | Spectrin | PhosphoSitePlus |
| S982 | DYQEKsPREVT | HPRD | |
| S982 | DYQEKsPREVT | SH3_1 | PhosphoSitePlus |
| Y2423 | SEGKPyVTKEE | HPRD; phosphoELM | |
| S1719 | LKDLNsQADSL | Spectrin | PhosphoSitePlus |
| T2016 | VQTLLtKQETF | Spectrin | PhosphoSitePlus |
| S2066 | LMKRWsQLLAN | Spectrin | PhosphoSitePlus |
| S1578 | TASDEsYKDPT | Spectrin | PhosphoSitePlus |
| T1797 | YGRDLtGVQNL | Spectrin | PhosphoSitePlus |
| Y1176 | QQQEVyGMMPR | PhosphoSitePlus | |
| S1323 | NQAWSsLGKRA | HPRD; phosphoELM | |
| S940 | LMSDLsAYGSS | HPRD | |
| S999 | LTLLNsTNKDW | HPRD | |
| S1217 | NERWRsLQQLA | HPRD; phosphoELM | |
| Y978 | LALYDyQEKSP | HPRD | |
| S1041 | LEEQGsIALRQ | PhosphoSitePlus; HPRD | |
| S2340 | FDKDKsGRLNH | efhand | PhosphoSitePlus |
| Y26 | QVLDRyHRFKE | Tetrabrachion | PhosphoSitePlus |
| Y2462 | PTAFDyVEFTR | efhand_Ca_insen | PhosphoSitePlus |
| S783 | QKLADsLRLQQ | PhosphoSitePlus; HPRD | |
| Y1411 | LAHGHyASPEI | Spectrin; Octopine_DH | PhosphoSitePlus |
| S1306 | QSHPEsAEDLQ | Spectrin | PhosphoSitePlus |
| Y1073 | QVEELyHSLLE | PhosphoSitePlus; HPRD | |
| T1184 | MPRDEtDSKTA | PhosphoSitePlus | |
| T667 | KLLEAtELKGI | Spectrin | PhosphoSitePlus |
| T667 | KLLEAtELKGI | HPRD | |
| S1190 | DSKTAsPWKSA | PhosphoSitePlus; HPRD | |
| S1755 | KSMAAsRRAKL | Spectrin | PhosphoSitePlus |
| S1207 | VATFNsIKELN | Spectrin | PhosphoSitePlus |
| T196 | FEEFQtDMAAH | Spectrin | PhosphoSitePlus |
| S999 | LTLLNsTNKDW | SH3_1 | PhosphoSitePlus |
| S1647 | FLVQKsAEKSQ | Spectrin | PhosphoSitePlus |
| S1647 | FLVQKsAEKSQ | HPRD | |
| Y976 | LVLALyDYQEK | SH3_1 | PhosphoSitePlus |
| T2434 | LYQNLtREQAD | efhand_Ca_insen | PhosphoSitePlus |
| Y942 | SDLSAyGSSIQ | Spectrin | PhosphoSitePlus |
| S517 | FEKSLsAQEEK | Spectrin | PhosphoSitePlus |
| S1217 | NERWRsLQQLA | Spectrin | PhosphoSitePlus |
| S2139 | DAFRSsLSSAQ | HPRD | |
| T2425 | GKPYVtKEELY | efhand_Ca_insen | PhosphoSitePlus |
| S1692 | GKDLAsVNNLL | Spectrin | PhosphoSitePlus |
| S2159 | DRQIKsFRVAS | Spectrin | PhosphoSitePlus |
| S1413 | HGHYAsPEIKQ | Spectrin; Octopine_DH | PhosphoSitePlus |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y1176 | AVQQQEVyGMMPRDE | ACP1 | HPRD |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000361816 | K1748N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000361816 | I2185V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361824 | F1467L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000361816 | A1970V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361816 | R1794W | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000361816 | R2467fs*5 | COSMIC | Breast Cancer | 16959974 | ENSP00000361816 | L2140H | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000361824 | A1970V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000361816 | P1017S | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000361816 | R2256Q | COSMIC | Pancreatic Cancer | ENSP00000361824 | A1975V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000361816 | L383I | BIOMART | Gastric Cancer | 21930507, 21930502 | ENSP00000361816 | E908D | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000361824 | E908D | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000361816 | F1467L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000361816 | S904C | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000361816 | L1157V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361816 | D1918N | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000361816 | S43F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361816 | M2395V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000361824 | S43F | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000361824 | M2400V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000361816 | C956fs*33 | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000361816 | Breast Cancer | Normal vs. Cancer | tissue | Up | 18257521 | ENSP00000361816 | Breast Cancer | Normal vs. Cancer | tissue | Down | 20560667 | ENSP00000361816 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.44 | 20739354 |
| Hyperphosphorylation site |
| SPTN1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LCK_HUMAN | SPTN1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRC_HUMAN | SPTN1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | SPTN1_HUMAN | kinase -> substrate | RegPhos |
| PPAC_HUMAN | SPTN1_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04530 | Tight junction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0015630 | microtubule cytoskeleton | IDA | cellular_component |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0016020 | membrane | TAS | cellular_component |
| GO:0032437 | cuticular plate | IEA | cellular_component |
| GO:0030507 | spectrin binding | IEA | molecular_function |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0030863 | cortical cytoskeleton | IEA | cellular_component |
| GO:0016328 | lateral plasma membrane | IEA | cellular_component |
| GO:0003779 | actin binding | IEA | molecular_function |
| GO:0005516 | calmodulin binding | IEA | molecular_function |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0030018 | Z disc | IEA | cellular_component |
| GO:0006921 | cellular component disassembly involved in executi | TAS | biological_process |
| GO:0008091 | spectrin | TAS | cellular_component |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0005200 | structural constituent of cytoskeleton | TAS | molecular_function |
| GO:0005916 | fascia adherens | IEA | cellular_component |
| GO:0051693 | actin filament capping | IEA | biological_process |