Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ANXA2_HUMAN
Description:annexin A2 [Source:HGNC Symbol;Acc:537]
Location:chr15 q22.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T21SFKMStVHEILHPRD
S314RKYGKsLYYYIAnnexinPhosphoSitePlus
T123MKGLGtDEDSLHPRD; SysPTM
Y24TPPSAyGSVKASrcRegPhos; SysPTM
S85KKELAsALKSAAnnexinPhosphoSitePlus
S92LKSALsGHLETAnnexinPhosphoSitePlus
Y24TPPSAyGSVKASRCphosphoELM; RegPhos; SysPTM
Y147EINRVyKEMYKAnnexin; YodAPhosphoSitePlus
T19EGDHStPPSAYPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T3HEILHPRD; phosphoELM; SysPTM
Y206GSVIDyELIDQHPRD
Y109KTPAQyDASELAnnexinPhosphoSitePlus
Y235DRYKSySPYDMYodA; AnnexinPhosphoSitePlus
S234FDRYKsYSPYDYodA; AnnexinPhosphoSitePlus
T171KEMYKtDLEKDHPRD
T3MSTVHeILRegPhos; SysPTM
Y334YGKSLyYYIQQHPRD
Y199DARDLyDAGVKYodA; AnnexinPhosphoSitePlus
Y199DARDLyDAGVKHPRD; phosphoELM
Y42TPPSAyGSVKAHPRD
Y316YGKSLyYYIQQAnnexinPhosphoSitePlus
S44PSAYGsVKAYTPRKCAHPRD
Y316YGKSLyYYIQQHPRD; phosphoELM
Y256KSYSPyDMLESHPRD
S22HSTPPsAYGSVPhosphoSitePlus; HPRD
S127GTDEDsLIEIIAnnexin; YodAPhosphoSitePlus
Y188GSVIDyELIDQYodAPhosphoSitePlus
Y75DIAFAyQRRTKHPRD
S184RAEDGsVIDYEYodAPhosphoSitePlus
Y336KSLYYyIQQDTHPRD
Y333QKALLyLCGGDAnnexinPhosphoSitePlus
Y335GKSLYyYIQQDHPRD
Y48GSVKAyTNFDAHPRD
S12ILCKLsLEGDHPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y275FADRLyDSMKGAnnexinPhosphoSitePlus
S2VHEIPRKCBHPRD
Y317GKSLYyYIQQDHPRD; phosphoELM
T153KEMYKtDLEKDHPRD
S202RAEDGsVIDYEHPRD
Y238KSYSPyDMLESYodA; AnnexinPhosphoSitePlus
S40HSTPPsAYGSVHPRD
Y24TPPSAyGSVKAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S134IEIICsRTNQEAnnexin; YodAPhosphoSitePlus
S20ASFKMsTVHEIPRKCBHPRD
S145GTDEDsLIEIIHPRD
T136IICSRtNQELQAnnexin; YodAPhosphoSitePlus
S2VHEIHPRD
Y317GKSLYyYIQQDAnnexinPhosphoSitePlus
Y147EINRVyKEMYKHPRD
S30ILCKLsLEGDHHPRD
Y165EINRVyKEMYKHPRD
Y30GSVKAyTNFDAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S26PSAYGsVKAYTPRKCAHPRD
S127GTDEDsLIEIIHPRD
S18LEGDHsTPPSAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S243YDMLEsIRKEVYodA; AnnexinPhosphoSitePlus
S26PSAYGsVKAYTPKCaRegPhos
S26PSAYGsVKAYTPKCa(PKC alphaRegPhos
T3___MStVHEILPhosphoSitePlus; SysPTM
Y75DIAFAyQRRTKAnnexinPhosphoSitePlus
S26PSAYGsVKAYTPhosphoSitePlus; phosphoELM
T31SVKAYtNFDAEPhosphoSitePlus
S36LEGDHsTPPSAHPRD
S2MSTVHeIPKCbRegPhos
T123MKGLGtDEDSLAnnexin; YodAPhosphoSitePlus; SysPTM
Y217DARDLyDAGVKHPRD
Y188GSVIDyELIDQHPRD; phosphoELM
T141MKGLGtDEDSLHPRD
S184RAEDGsVIDYEHPRD
Y232KVFDRyKSYSPYodA; AnnexinPhosphoSitePlus
Y318KSLYYyIQQDTHPRD; phosphoELM
Y93DIAFAyQRRTKHPRD
Y238KSYSPyDMLESHPRD; phosphoELM
Y318KSLYYyIQQDTAnnexinPhosphoSitePlus
S26PSAYGsVKAYTPKC_alphaphosphoELM
T37EGDHStPPSAYHPRD
S26PSAYGsVKAYTPKC_groupphosphoELM; RegPhos

Dephosphorylation site
ANXA2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000346032T141PCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000411352LeukemiaNormal vs. Cancercell lineUp2.417022645
ENSP00000411352LeukemiaNormal vs. Cancercell lineUp2.217022645
ENSP00000411352breast ductal carcinomaNormal vs. CancertissueUp18482919
ENSP00000411352Breast CancerNormal vs. Cancercell lineUp414997480
ENSP00000411352Breast CancerNormal vs. Cancercell lineDown0.1116596714
ENSP00000411352Breast CancerNormal vs. Cancercell lineDown0.2616596714
ENSP00000411352Breast CancerNormal vs. Cancercell lineDown0.2616596714
ENSP00000411352MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) overEXPressed)cell lineDown0.6717854218
ENSP00000411352Hepatocellular CarcinomaNormal vs. CancertissueUp2.411866469
ENSP00000411352Hepatocellular CarcinomaNormal vs. Cancercell lineUp3.419120023
ENSP00000411352Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000411352Lung CancerNormal vs. CancertissueDown16342241
ENSP00000411352Lung CancerCancer vs. Cancercell lineUp17284061
ENSP00000411352Lung CancerTreatment(none vs 20 mg/mL GTE treatment)cell lineUp2.819137550
ENSP00000411352Lung CancerTreatment(none vs 40 mg/mL GTE treatment)cell lineUp2.619137550
ENSP00000411352Gastric CancerNormal vs. CancertissueDown0.4319330469
ENSP00000411352Breast CancerMetastasiscell lineUp219321434
ENSP00000411352Breast CancerNormal vs. Cancercell lineDown0.1220052998
ENSP00000411352Breast CancerNormal vs. Cancercell lineDown0.1820052998
ENSP00000411352Breast CancerNormal vs. Cancercell lineDown0.2820052998
ENSP00000411352Breast CancerNormal vs. Cancercell lineDown0.4220052998
ENSP00000411352Breast CancerMetastasiscell lineUp2.420052998
ENSP00000411352Breast CancerMetastasiscell lineUp2.520052998
ENSP00000411352Breast CancerNormal vs. CancertissueUp1.720087651
ENSP00000411352Breast CancerNormal vs. CancertissueUp220087651
ENSP00000411352Breast CancerCancer vs. Cancer (Non-TNBC vs. TNBC)cell lineUp20596302
ENSP00000411352breast ductal carcinomaNormal vs. CancertissueUp18564057
ENSP00000411352Renal CancerNormal vs. CancertissueUp2.9-10.412923786
ENSP00000411352Ovarian CancerMetastasiscell lineDown0.417892554
ENSP00000411352Pancreatic CancerNormal vs. CancertissueUp215526344
ENSP00000411352Uterine CancerNormal vs. CancertissueUp16051329
ENSP00000411352Uterine CancerNormal vs. CancertissueUp19771267
ENSP00000411352Hepatocellular CarcinomaNormal vs. CancertissueUp3.311866469
ENSP00000411352pancreatic ductal adenocarcinomaNormal vs. CancertissueUp17492507

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y188YodAEDGSVIDyELIDQDAcholangiocellular carcinoma21253578PhosphoSitePlus
Y199YodA; AnnexinDQDARDLyDAGVKRKcholangiocellular carcinoma21253578PhosphoSitePlus
Y238YodA; AnnexinRYKSYSPyDMLESIRcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KPCB_HUMANANXA2_HUMANkinase -> substrateHPRD
ZAGL2_HUMANANXA2_HUMANkinase -> substrateRegPhos
FGFR1_HUMANANXA2_HUMANkinase -> substrateRobert H Newman (2013)
BMX_HUMANANXA2_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANANXA2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCZ_HUMANANXA2_HUMANkinase -> substrateRobert H Newman (2013)
SRC_HUMANANXA2_HUMANkinase -> substrateRegPhos
FAK2_HUMANANXA2_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANANXA2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ANXA2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043220Schmidt-Lanterman incisureIEAcellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0042470melanosomeIEAcellular_component
GO:0019897extrinsic to plasma membraneIEAcellular_component
GO:0042730fibrinolysisIEAbiological_process
GO:0017137Rab GTPase bindingIEAmolecular_function
GO:0071229cellular response to acidIEAbiological_process
GO:0007589body fluid secretionIEAbiological_process
GO:0005811lipid particleIDAcellular_component
GO:0043234protein complexIEAcellular_component
GO:0030199collagen fibril organizationIEAbiological_process
GO:0031340positive regulation of vesicle fusionIDAbiological_process
GO:0042383sarcolemmaIEAcellular_component
GO:0005604basement membraneIEAcellular_component
GO:0005546phosphatidylinositol-4,5-bisphosphate bindingIEAmolecular_function
GO:0004859phospholipase inhibitor activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0008092cytoskeletal protein bindingIEAmolecular_function
GO:0001501skeletal system developmentTASbiological_process
GO:0005544calcium-dependent phospholipid bindingIEAmolecular_function
GO:0031012extracellular matrixISScellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0030496midbodyIDAcellular_component
GO:0051099positive regulation of bindingIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005769early endosomeIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0035749myelin sheath adaxonal regionIEAcellular_component


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