Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:VGFR2_HUMAN
Description:kinase insert domain receptor (a type III receptor tyrosine kinase) [Source:HGNC Symbol;Acc:6307]
Location:chr4 q12
Node attribute:PPI(source); substrate; kinase; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1059YKDPDyVRKGDPkinase_TyrPhosphoSitePlus
Y1059YKDPDyVRKGDKDRHPRD; RegPhos
Y1059YKDPDyVRKGDphosphoELM
S1281TKLSPsFGGMVPhosphoSitePlus
Y801ELKTGyLSIVMPhosphoSitePlus; phosphoELM; RegPhos
Y1175QDGKDyIVLPIKDRphosphoELM; RegPhos
T1238PVSVKtFEDIPPhosphoSitePlus; HPRD
Y1054LARDIyKDPDYKDRHPRD; phosphoELM; RegPhos
Y1054LARDIyKDPDYphosphoELM
S982FVEEKsLSDVEPkinase_TyrPhosphoSitePlus
Y1175QDGKDyIVLPIPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S711TLVEDsGIVLKI-setPhosphoSitePlus
S1235KSRPVsVKTFEPhosphoSitePlus
Y951RQGKDyVGAIPphosphoELM
Y1214DPKFHyDNTAGKDRphosphoELM; RegPhos
Y1214DPKFHyDNTAGPhosphoSitePlus; HPRD; RegPhos
Y1054LARDIyKDPDYPkinase_TyrPhosphoSitePlus
Y1223AGISQyLQNSKPhosphoSitePlus
Y951RQGKDyVGAIPPkinase_TyrPhosphoSitePlus
Y996APEDLyKDFLTKDRHPRD; phosphoELM; RegPhos
S984EEKSLsDVEEEPkinase_TyrPhosphoSitePlus
S1288GGMVPsKSRESPhosphoSitePlus
Y951RQGKDyVGAIPKDRHPRD; phosphoELM; RegPhos
T1217FHYDNtAGISQPhosphoSitePlus
S1279DRTKLsPSFGGPhosphoSitePlus
Y996APEDLyKDFLTPkinase_TyrPhosphoSitePlus
Y1059YKDPDyVRKGDautocatalysis RegPhos
S1290MVPSKsRESVAPhosphoSitePlus

Dephosphorylation site
VGFR2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263923P1280LBIOMARTBreast Cancer21930507, 21930502
ENSP00000263923V476LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000263923S984TDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000263923A973SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000263923G1308*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000263923P1210LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000263923R275LBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000263923A248GGreenman2007, HPIRenal Cancer17344846, 18428421
ENSP00000263923G873RBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000263923V1041IBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000263923G1145EDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000263923G873RSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000263923Q2RGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000263923L1140MDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000263923R275LSjoblom2006Intestines Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000263923Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.515169874
ENSP00000263923Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
VGFR2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
VEGFA_HUMANVGFR2_HUMANligand -> receptorHPMR
ZAGL2_HUMANVGFR2_HUMANkinase -> substrateRegPhos
VGFR2_HUMANVGFR2_HUMANkinase -> substrateRegPhos
VGFR2_HUMANSHC2_HUMANotherKEGG
VGFR2_HUMANPAXI_HUMANotherKEGG
VGFR2_HUMANSRC_HUMANotherKEGG
VGFR2_HUMANFAK1_HUMANotherKEGG
VGFR2_HUMANPLCG1_HUMANotherKEGG
VEGFD_HUMANVGFR2_HUMANotherKEGG
VGFR2_HUMANSH22A_HUMANotherKEGG
VGFR2_HUMANPI3R5_HUMANotherKEGG
VGFR2_HUMANCDC42_HUMANotherKEGG
VEGFA_HUMANVGFR2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04510Focal adhesion
hsa04060Cytokine-cytokine receptor interaction
hsa04370VEGF signaling pathway
hsa04144Endocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005524ATP bindingIEAmolecular_function
GO:0035924cellular response to vascular endothelial growth fIDAbiological_process
GO:0005768endosomeIDAcellular_component
GO:0001570vasculogenesisIEAbiological_process
GO:0019838growth factor bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIDAbiological_process
GO:0048754branching morphogenesis of a tubeIEAbiological_process
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0005178integrin bindingIPImolecular_function
GO:0038083peptidyl-tyrosine autophosphorylationISSbiological_process
GO:0030335positive regulation of cell migrationIMPbiological_process
GO:0038084vascular endothelial growth factor signaling pathwIDAbiological_process
GO:0002042cell migration involved in sprouting angiogenesisISSbiological_process
GO:0051894positive regulation of focal adhesion assemblyIDAbiological_process
GO:0005886plasma membraneISScellular_component
GO:0005576extracellular regionIEAcellular_component
GO:0001570vasculogenesisISSbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIEAbiological_process
GO:0001525angiogenesisTASbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actTASmolecular_function
GO:0019838growth factor bindingIPImolecular_function
GO:0014068positive regulation of phosphatidylinositol 3-kinaIDAbiological_process
GO:0016477cell migrationIEAbiological_process
GO:0045766positive regulation of angiogenesisIMPbiological_process
GO:0005021vascular endothelial growth factor-activated recepIDAmolecular_function
GO:0005021vascular endothelial growth factor-activated recepIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0055074calcium ion homeostasisIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0030324lung developmentIEAbiological_process
GO:0048010vascular endothelial growth factor receptor signalIDAbiological_process
GO:0030097hemopoiesisIEAbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0071944cell peripheryIEAcellular_component
GO:0048286lung alveolus developmentIEAbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0001945lymph vessel developmentIEAbiological_process
GO:0045121membrane raftIDAcellular_component
GO:0023014signal transduction by phosphorylationTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0045446endothelial cell differentiationIEAbiological_process
GO:0043129surfactant homeostasisIEAbiological_process
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0004713protein tyrosine kinase activityIDAmolecular_function
GO:0009897external side of plasma membraneIEAcellular_component
GO:0035584calcium-mediated signaling using intracellular calIMPbiological_process
GO:0051770positive regulation of nitric-oxide synthase biosyIDAbiological_process
GO:0001938positive regulation of endothelial cell proliferatIMPbiological_process
GO:0005769early endosomeISScellular_component
GO:0005634nucleusIEAcellular_component
GO:0050927positive regulation of positive chemotaxisIDAbiological_process
GO:0008360regulation of cell shapeIDAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0001541ovarian follicle developmentIEAbiological_process
GO:0051879Hsp90 protein bindingTASmolecular_function
GO:0007169transmembrane receptor protein tyrosine kinase sigTASbiological_process
GO:0045165cell fate commitmentIEAbiological_process
GO:0038085vascular endothelial growth factor bindingIPImolecular_function
GO:0048469cell maturationIEAbiological_process
GO:0004716receptor signaling protein tyrosine kinase activitTASmolecular_function
GO:0002053positive regulation of mesenchymal cell proliferatIEAbiological_process
GO:0048010vascular endothelial growth factor receptor signalIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:2000352negative regulation of endothelial cell apoptotic IDAbiological_process
GO:0035162embryonic hemopoiesisISSbiological_process
GO:0010595positive regulation of endothelial cell migrationIMPbiological_process
GO:0003158endothelium developmentISSbiological_process