| UniProt/SwissProt ID: | DAB1_HUMAN |
| Description: | disabled homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:2661] |
| Location: | chr1 p32.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y198 | VEDPVyQYIVF | SRC | HPRD; RegPhos |
| S524 | APRQSsPSKSS | CDK_group | phosphoELM; RegPhos |
| S491 | APRQSsPSKSS | CDK5 | HPRD |
| S548 | EEGFEsPSKSE | CDK_group | phosphoELM; RegPhos |
| Y232 | KKEGVyDVPKS | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y198 | VEDPVyQYIVF | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y185 | CEQAVyQTILE | SRC | HPRD; RegPhos |
| S515 | EEGFEsPSKSE | CDK5 | HPRD |
| S524 | APRQSsPSKSS | CDK5 | RegPhos |
| Y220 | TEENIyQVPTS | PhosphoSitePlus; phosphoELM; RegPhos | |
| S526 | RQSSPsKSSAS | PhosphoSitePlus | |
| T506 | NLTPVtSTTPS | PhosphoSitePlus | |
| Y220 | TEENIyQVPTS | SRC | HPRD; RegPhos |
| S524 | APRQSsPSKSS | CDK5 | RegPhos |
| Y200 | DPVYQyIVFEA | SRC | HPRD; RegPhos |
| S524 | APRQSsPSKSS | PhosphoSitePlus | |
| Y232 | KKEGVyDVPKS | SRC | HPRD; RegPhos |
| Dephosphorylation site |
| DAB1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000360277 | Q320H | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000360277 | M321K | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000360277 | V11L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000360277 | S519I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000360277 | A365T | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000360274 | *214Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000360278 | *556C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000360277 | *556C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000360274 | *214C | COSMIC | Neoplasms by Histologic Type | 12673678 | ENSP00000360277 | P434H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000360277 | G451R | COSMIC | Skin Cancer | 21984974 | ENSP00000360280 | *556C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000360277 | S495L | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| DAB1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DAB1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | DAB1_HUMAN | kinase -> substrate | RegPhos |
| SRC_HUMAN | DAB1_HUMAN | kinase -> substrate | RegPhos |
| CDK5_HUMAN | DAB1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| DAB1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007628 | adult walking behavior | IEA | biological_process |
| GO:0050771 | negative regulation of axonogenesis | IEA | biological_process |
| GO:0021799 | cerebral cortex radially oriented cell migration | IEA | biological_process |
| GO:0021813 | cell-cell adhesion involved in neuronal-glial inte | IEA | biological_process |
| GO:0001764 | neuron migration | IEA | biological_process |
| GO:0007162 | negative regulation of cell adhesion | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0046426 | negative regulation of JAK-STAT cascade | IEA | biological_process |
| GO:0016358 | dendrite development | IEA | biological_process |
| GO:0021795 | cerebral cortex cell migration | IEA | biological_process |
| GO:0048712 | negative regulation of astrocyte differentiation | IEA | biological_process |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0045666 | positive regulation of neuron differentiation | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0051645 | Golgi localization | IEA | biological_process |
| GO:0021942 | radial glia guided migration of Purkinje cell | IEA | biological_process |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |
| GO:0007494 | midgut development | IEA | biological_process |
| GO:0042493 | response to drug | IEA | biological_process |
| GO:0043548 | phosphatidylinositol 3-kinase binding | IEA | molecular_function |
| GO:0014069 | postsynaptic density | IEA | cellular_component |
| GO:0021987 | cerebral cortex development | IEA | biological_process |
| GO:0045177 | apical part of cell | IEA | cellular_component |
| GO:0045860 | positive regulation of protein kinase activity | IEA | biological_process |
| GO:0021589 | cerebellum structural organization | IEA | biological_process |
| GO:0005903 | brush border | IEA | cellular_component |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0043025 | neuronal cell body | IEA | cellular_component |
| GO:0043005 | neuron projection | IEA | cellular_component |
| GO:0007420 | brain development | IEA | biological_process |
| GO:0021517 | ventral spinal cord development | IEA | biological_process |