Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RASH_HUMAN
Description:v-Ha-ras Harvey rat sarcoma viral oncogene homolog [Source:HGNC Symbol;Acc:5173]
Location:chr11 p15.5
Node attribute:PPI(source); PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y64AGQEEySAMRDRas; Ldh_1_NPhosphoSitePlus
T35DEYDPtIEDSYphosphoELM
S183GPGCMsCKCVLPhosphoSitePlus
S145PYIETsAKTRQHPRD
Y32HFVDEyDPTIERas; Ldh_1_NPhosphoSitePlus
T148ETSAKtRQGVERasPhosphoSitePlus
S136QDLARsYGIPYHPRD
S145PYIETsAKTRQRasPhosphoSitePlus
Y157VEDAFyTLVRERasPhosphoSitePlus
S39PTIEDsYRKQVRas; Ldh_1_NPhosphoSitePlus
T144IPYIEtSAKTRRasPhosphoSitePlus
T35DEYDPtIEDSYRas; Ldh_1_NPhosphoSitePlus

Dephosphorylation site
RASH_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000309845Q61KOMIMThyroid Carcinoma12727991 19855393
ENSP00000380722Q61KCOSMICSkin Cancer21984974
ENSP00000380723Q61KOMIMThyroid Carcinoma12727991 19855393
ENSP00000309845G12VOMIMUrinary Bladder Cancer7177195 2999610 3537694 6092966 6330729 16170316
ENSP00000407586Q61KHPIfollicular thyroid carcinoma18073111 12727991
ENSP00000407586Q61KOMIMThyroid Carcinoma12727991 19855393
ENSP00000407586G12SHPIOral Cancer1459726 16170316 16329078 16443854 17054105 17412879 21344638 21834037 21850009 21438134 20979192 19206176 19669404 17979197 18355852 18039947 17412879 17054105 17324647 16969868 16881968 16835863 2064725
ENSP00000380722G12DCOSMICHead and Neck Cancer21798893
ENSP00000309845Q61KHPIfollicular thyroid carcinoma18073111 12727991
ENSP00000380722G13VCOSMICHead and Neck Cancer21798893
ENSP00000407586G12VOMIMUrinary Bladder Cancer7177195 2999610 3537694 6092966 6330729 16170316
ENSP00000380723A66TBIOMARTBreast Cancer21930507, 21930502
ENSP00000380722D119NCOSMICHead and Neck Cancer21798897
ENSP00000380723G12VOMIMUrinary Bladder Cancer7177195 2999610 3537694 6092966 6330729 16170316
ENSP00000407586A66TBIOMARTBreast Cancer21930507, 21930502
ENSP00000388246A66TBIOMARTBreast Cancer21930507, 21930502
ENSP00000380723Q61KHPIfollicular thyroid carcinoma18073111 12727991
ENSP00000380723G12SHPIOral Cancer1459726 16170316 16329078 16443854 17054105 17412879 21344638 21834037 21850009 21438134 20979192 19206176 19669404 17979197 18355852 18039947 17412879 17054105 17324647 16969868 16881968 16835863 2064725
ENSP00000309845A66TBIOMARTBreast Cancer21930507, 21930502
ENSP00000309845G12SHPIOral Cancer1459726 16170316 16329078 16443854 17054105 17412879 21344638 21834037 21850009 21438134 20979192 19206176 19669404 17979197 18355852 18039947 17412879 17054105 17324647 16969868 16881968 16835863 2064725
ENSP00000380722S158PDing2008, COSMICLung Cancer18948947
ENSP00000380722A66TBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000388246Breast CancerNormal vs. Cancercell lineUp4.916596714

Hyperphosphorylation site
RASH_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SOS1_HUMANRASH_HUMANotherKEGG
SRC_HUMANRASH_HUMANotherKEGG
SPHK2_HUMANRASH_HUMANotherKEGG
GRP3_HUMANRASH_HUMANotherKEGG
RASH_HUMANARAF_HUMANotherKEGG
RASH_HUMANPI3R5_HUMANotherKEGG
RASH_HUMANFOS_HUMANotherKEGG
RASH_HUMANRAF1_HUMANotherKEGG
GRP1_HUMANRASH_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05221Acute myeloid leukemia
hsa05215Prostate cancer
hsa04810Regulation of actin cytoskeleton
hsa04010MAPK signaling pathway
hsa04662B cell receptor signaling pathway
hsa04725Cholinergic synapse
hsa04722Neurotrophin signaling pathway
hsa05218Melanoma
hsa05216Thyroid cancer
hsa05220Chronic myeloid leukemia
hsa04650Natural killer cell mediated cytotoxicity
hsa05223Non-small cell lung cancer
hsa04144Endocytosis
hsa04664Fc epsilon RI signaling pathway
hsa04012ErbB signaling pathway
hsa04510Focal adhesion
hsa04530Tight junction
hsa04370VEGF signaling pathway
hsa05166HTLV-I infection
hsa04660T cell receptor signaling pathway
hsa04916Melanogenesis
hsa04720Long-term potentiation
hsa04730Long-term depression
hsa04726Serotonergic synapse
hsa04360Axon guidance
hsa05203Viral carcinogenesis
hsa05219Bladder cancer
hsa05034Alcoholism
hsa04540Gap junction
hsa04912GnRH signaling pathway
hsa04910Insulin signaling pathway
hsa05214Glioma
hsa05213Endometrial cancer
hsa05160Hepatitis C
hsa05211Renal cell carcinoma
hsa04062Chemokine signaling pathway
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0035176social behaviorIEAbiological_process
GO:0007569cell agingIEAbiological_process
GO:0001934positive regulation of protein phosphorylationIDAbiological_process
GO:0031575mitotic cell cycle G1/S transition checkpointIDAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0008542visual learningIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0005525GTP bindingIDAmolecular_function
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0051291protein heterooligomerizationIEAbiological_process
GO:0007165signal transductionNASbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0045740positive regulation of DNA replicationIDAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0046330positive regulation of JNK cascadeIDAbiological_process
GO:0090398cellular senescenceIDAbiological_process
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0045740positive regulation of DNA replicationIEAbiological_process
GO:0010629negative regulation of gene expressionIDAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:0097193intrinsic apoptotic signaling pathwayIEAbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:2000251positive regulation of actin cytoskeleton reorganiIDAbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0000165MAPK cascadeTASbiological_process
GO:0090303positive regulation of wound healingIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0048169regulation of long-term neuronal synaptic plasticiIEAbiological_process
GO:0000186activation of MAPKK activityTASbiological_process
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0051146striated muscle cell differentiationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0034259negative regulation of Rho GTPase activityIDAbiological_process
GO:2000630positive regulation of miRNA metabolic processIDAbiological_process
GO:0032228regulation of synaptic transmission, GABAergicIEAbiological_process
GO:0007050cell cycle arrestIDAbiological_process
GO:1900029positive regulation of ruffle assemblyIDAbiological_process
GO:0007265Ras protein signal transductionIDAbiological_process
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0005622intracellularIEAcellular_component
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0009887organ morphogenesisTASbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0015684ferrous iron transportIEAbiological_process
GO:0015031protein transportIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0043410positive regulation of MAPK cascadeIDAbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIMPbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0006184GTP catabolic processIEAbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0007265Ras protein signal transductionIEAbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0032855positive regulation of Rac GTPase activityIDAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0043406positive regulation of MAP kinase activityIDAbiological_process
GO:0015093ferrous iron transmembrane transporter activityIEAmolecular_function
GO:0006897endocytosisIEAbiological_process
GO:0000139Golgi membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0035022positive regulation of Rac protein signal transducIEAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0046579positive regulation of Ras protein signal transducIEAbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0006935chemotaxisTASbiological_process