Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DOK2_HUMAN
Description:docking protein 2, 56kDa [Source:HGNC Symbol;Acc:2991]
Location:chr8 p21.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y345RPDHIyDEPEGSRCHPRD
T189GPEPGtQLYDWIRSPhosphoSitePlus
Y402QPGTEyDNVVLPhosphoSitePlus
S332DPLYDsIEETLPhosphoSitePlus
Y12KQGFLyLQQQQPHPhosphoSitePlus
S309DAVARsLGKNFPhosphoSitePlus
Y357AALSLyDSPQEPhosphoSitePlus
Y299GQEGEyAVPFDSRCHPRD; SysPTM
Y299GQEGEyAVPFDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S269LPRPDsPYSRPPhosphoSitePlus
S277SRPHDsLPPPSPhosphoSitePlus
S122QRKELsGPEGKPhosphoSitePlus
Y299GQEGEyAVPFDLYNHPRD; SysPTM
Y345RPDHIyDEPEGHCKHPRD
S140ENELYsSAVTVPhosphoSitePlus
Y170HLRGSyTLRAGIRSPhosphoSitePlus
Y271RPDSPySRPHDLYNHPRD
Y345RPDHIyDEPEGPhosphoSitePlus; HPRD; phosphoELM
S141NELYSsAVTVGPhosphoSitePlus
Y345RPDHIyDEPEGLYNHPRD
Y271RPDSPySRPHDPhosphoSitePlus; HPRD; phosphoELM
Y139EENELySSAVTPhosphoSitePlus; HPRD; phosphoELM
Y271RPDSPySRPHDSRCHPRD
S129PEGKQsRPCMEPhosphoSitePlus
Y271RPDSPySRPHDHCKHPRD
T144YSSAVtVGPHKPhosphoSitePlus
Y330LADPLyDSIEEPhosphoSitePlus
Y192PGTQLyDWPYRIRSPhosphoSitePlus
S282SLPPPsPTTPVPhosphoSitePlus
T336DSIEEtLPPRPPhosphoSitePlus
Y299GQEGEyAVPFDHCKHPRD; SysPTM

Dephosphorylation site
DOK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000276420V384FCOSMICOvarian Cancer21720365

Differential expressed protein
DOK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DOK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HCK_HUMANDOK2_HUMANkinase -> substrateHPRD
SRC_HUMANDOK2_HUMANkinase -> substrateHPRD
LYN_HUMANDOK2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
DOK2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005543phospholipid bindingIEAmolecular_function
GO:0005057receptor signaling protein activityIEAmolecular_function
GO:0007265Ras protein signal transductionIEAbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005068transmembrane receptor protein tyrosine kinase adaIEAmolecular_function
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005158insulin receptor bindingIEAmolecular_function
GO:0050900leukocyte migrationTASbiological_process


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