Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GRB2_HUMAN
Description:growth factor receptor-bound protein 2 [Source:HGNC Symbol;Acc:4566]
Location:chr17 q25.1
Node attribute:PPI(target); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y7EAIAKyDFKATSH3_1PhosphoSitePlus
Y160PQQPTyVQALFSRCHPRD; RegPhos; SysPTM
T159VPQQPtYVQALPhosphoSitePlus
Y119PQQPTyVQALFSRCHPRD
Y52FIPKNyIEMKPPhosphoSitePlus
Y209MFPRNyVTPVNEGFRphosphoELM; RegPhos; SysPTM
T211PRNYVtPVNRNPhosphoSitePlus; SysPTM
Y168MFPRNyVTPVNEGFRHPRD
Y209MFPRNyVTPVNPhosphoSitePlus; HPRD; RegPhos; SysPTM
T170PRNYVtPVNRHPRD
Y160PQQPTyVQALFPhosphoSitePlus; RegPhos; SysPTM
T211PRNYVtPVNRHPRD; phosphoELM; SysPTM
Y37CDQNWyKAELNSH3_1PhosphoSitePlus

Dephosphorylation site
GRB2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376345F9LCOSMICOvarian Cancer21720365
ENSP00000339007E130DCOSMICOvarian Cancer21720365
ENSP00000376347F95VBIOMARTBreast Cancer21930507, 21930502
ENSP00000339007F95VBIOMARTBreast Cancer21930507, 21930502
ENSP00000376345F95VBIOMARTBreast Cancer21930507, 21930502
ENSP00000339007F9LCOSMICOvarian Cancer21720365
ENSP00000376347E130DCOSMICOvarian Cancer21720365
ENSP00000376347F9LCOSMICOvarian Cancer21720365
ENSP00000376345E130DCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000376347Non-small cell lung carcinomaMetastasiscell lineDown17537172
ENSP00000376347LeukemiaNormal vs. Cancercell lineDown0.3317022645
ENSP00000376347LeukemiaNormal vs. Cancercell lineUp4.417022645
ENSP00000376347Lung CancerTreatment (none vs. FK228 treatment)cell lineUp18549279
ENSP00000376347Breast CancerNormal vs. CancertissueUp216470630
ENSP00000376347hepatitis B virusNormal vs. Cancercell lineUp6.119187611
ENSP00000376347Hepatocellular CarcinomaMetastasiscell lineDown0.5719016532
ENSP00000376347Breast CancerNormal vs. Cancercell lineUp3.220052998
ENSP00000376347Breast CancerNormal vs. Cancercell lineUp1.620052998
ENSP00000376347Breast CancerMetastasiscell lineDown0.5120052998
ENSP00000376347Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueUp1.616807943

Hyperphosphorylation site
GRB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SRC_HUMANGRB2_HUMANkinase -> substrateHPRD; RegPhos
EGFR_HUMANGRB2_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANGRB2_HUMANkinase -> substrateRegPhos
GRB2_HUMANSOS1_HUMANotherKEGG
EGFR_HUMANGRB2_HUMANotherKEGG
CD28_HUMANGRB2_HUMANotherKEGG
FAK1_HUMANGRB2_HUMANotherKEGG
LAT_HUMANGRB2_HUMANotherKEGG
SHC2_HUMANGRB2_HUMANotherKEGG
IRS1_HUMANGRB2_HUMANotherKEGG
GRB2_HUMANGAB1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway
hsa05215Prostate cancer
hsa04540Gap junction
hsa04912GnRH signaling pathway
hsa05200Pathways in cancer
hsa05213Endometrial cancer
hsa04650Natural killer cell mediated cytotoxicity
hsa05160Hepatitis C
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04062Chemokine signaling pathway
hsa05223Non-small cell lung cancer
hsa05203Viral carcinogenesis
hsa04722Neurotrophin signaling pathway
hsa05214Glioma
hsa05220Chronic myeloid leukemia
hsa04630Jak-STAT signaling pathway
hsa05221Acute myeloid leukemia
hsa05034Alcoholism
hsa04012ErbB signaling pathway
hsa04010MAPK signaling pathway
hsa05211Renal cell carcinoma
hsa04320Dorso-ventral axis formation
hsa04664Fc epsilon RI signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005070SH3/SH2 adaptor activityTASmolecular_function
GO:0005070SH3/SH2 adaptor activityIEAmolecular_function
GO:0051219phosphoprotein bindingIEAmolecular_function
GO:0005168neurotrophin TRKA receptor bindingIPImolecular_function
GO:0007265Ras protein signal transductionTASbiological_process
GO:2000379positive regulation of reactive oxygen species metIMPbiological_process
GO:0043560insulin receptor substrate bindingIPImolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007568agingIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0031295T cell costimulationTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0046875ephrin receptor bindingIPImolecular_function
GO:0019901protein kinase bindingIPImolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0031623receptor internalizationIMPbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0043234protein complexIEAcellular_component
GO:0001784phosphotyrosine bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0008286insulin receptor signaling pathwayIPIbiological_process
GO:0012506vesicle membraneIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0030154cell differentiationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0071479cellular response to ionizing radiationIMPbiological_process
GO:0048646anatomical structure formation involved in morphogIEAbiological_process
GO:0008180signalosomeIDAcellular_component
GO:0030838positive regulation of actin filament polymerizatiIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030168platelet activationTASbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0070436Grb2-EGFR complexIDAcellular_component
GO:0005154epidermal growth factor receptor bindingIPImolecular_function
GO:0005634nucleusIDAcellular_component
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0017124SH3 domain bindingIDAmolecular_function
GO:0043408regulation of MAPK cascadeIEAbiological_process
GO:0042059negative regulation of epidermal growth factor recTASbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0008180signalosomeIEAcellular_component
GO:0051291protein heterooligomerizationIEAbiological_process
GO:0060670branching involved in labyrinthine layer morphogenIEAbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0007596blood coagulationTASbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0043560insulin receptor substrate bindingIEAmolecular_function
GO:0005768endosomeIDAcellular_component
GO:0007267cell-cell signalingTASbiological_process
GO:0042770signal transduction in response to DNA damageIMPbiological_process
GO:0019903protein phosphatase bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0019048virus-host interactionIEAbiological_process


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