| UniProt/SwissProt ID: | RGS16_HUMAN |
| Description: | regulator of G-protein signaling 16 [Source:HGNC Symbol;Acc:9997] |
| Location: | chr1 q25.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y168 | MEKDSyPRFLK | RGS | PhosphoSitePlus |
| S195 | TLSSCsLDEPS | HPRD; RegPhos | |
| Y168 | MEKDSyPRFLK | EGFR | HPRD; phosphoELM; RegPhos |
| Y177 | LKSPAyRDLAA | EGFR | HPRD; phosphoELM; RegPhos |
| Y177 | LKSPAyRDLAA | RGS | PhosphoSitePlus |
| Y168 | MEKDSyPRFLK | SRC | HPRD; phosphoELM; RegPhos |
| Y177 | LKSPAyRDLAA | Src | RegPhos |
| Y168 | MEKDSyPRFLK | CSK | HPRD; RegPhos |
| Y168 | MEKDSyPRFLK | Src | RegPhos |
| Y177 | LKSPAyRDLAA | SRC | phosphoELM |
| Y177 | LKSPAyRDLAA | Lyn | phosphoELM; RegPhos |
| Y168 | MEKDSyPRFLK | LYN | HPRD; RegPhos |
| Y177 | LKSPAyRDLAA | RegPhos | |
| Y177 | LKSPAyRDLAA | Src_group | RegPhos |
| Dephosphorylation site |
| RGS16_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000356529 | *203L | COSMIC | Hepatocellular Carcinoma | 21822264 |
| Differential expressed protein |
| RGS16_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RGS16_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| EGFR_HUMAN | RGS16_HUMAN | kinase -> substrate | RegPhos |
| SRC_HUMAN | RGS16_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | RGS16_HUMAN | kinase -> substrate | RegPhos |
| CSK_HUMAN | RGS16_HUMAN | kinase -> substrate | HPRD; RegPhos |
| LYN_HUMAN | RGS16_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| RGS16_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | IBA | cellular_component |
| GO:0043547 | positive regulation of GTPase activity | IBA | biological_process |
| GO:0038032 | termination of G-protein coupled receptor signalin | IEA | biological_process |
| GO:0005096 | GTPase activator activity | IBA | molecular_function |
| GO:0008277 | regulation of G-protein coupled receptor protein s | TAS | biological_process |
| GO:0005737 | cytoplasm | IBA | cellular_component |
| GO:0005516 | calmodulin binding | TAS | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007601 | visual perception | TAS | biological_process |