Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SHC1_HUMAN
Description:SHC (Src homology 2 domain containing) transforming protein 1 [Source:HGNC Symbol;Acc:10840]
Location:chr1 q21.3
Node attribute:kinase; effector; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y350PDHQYyNDFPGSrcRegPhos
Y240PDHQYyNDFPGSYKHPRD
Y349PPDHQyYNDFPSrcRegPhos
Y350PDHQYyNDFPGFLT3RegPhos
S54LPGDDsPTTLCPhosphoSitePlus; phosphoELM; RegPhos
Y427FDDPSyVNVQNINSRHPRD; RegPhos
Y350PDHQYyNDFPGSRCHPRD; RegPhos
Y427FDDPSyVNVQNPhosphoSitePlus; phosphoELM; RegPhos
S36PEELPsPSASSPhosphoSitePlus; phosphoELM; RegPhos
Y427FDDPSyVNVQNLCKHPRD; RegPhos
S494FHGKLsRREAESH2PhosphoSitePlus
Y427FDDPSyVNVQNFLT4phosphoELM; RegPhos
Y427FDDPSyVNVQNFLT3RegPhos
Y239PPDHQyYNDFPZAP70HPRD
Y350PDHQYyNDFPGSykRegPhos
Y239PPDHQyYNDFPSRCHPRD
Y349PPDHQyYNDFPZAP70HPRD; phosphoELM; RegPhos
S335AGFDGsAWDEEPhosphoSitePlus
Y427FDDPSyVNVQNZAP70HPRD; phosphoELM; RegPhos
T386APNAQtPSHLGPhosphoSitePlus; phosphoELM; RegPhos
S115DMNKLsGGGGRPhosphoSitePlus
S29WTRHGsFVNKPPRKCAHPRD
Y427FDDPSyVNVQNFYNHPRD; RegPhos
Y349PPDHQyYNDFPFLT3RegPhos
Y427FDDPSyVNVQNFynRegPhos
Y427FDDPSyVNVQNPDGFR_groupRegPhos
Y349PPDHQyYNDFPSYKHPRD; phosphoELM; RegPhos
Y240PDHQYyNDFPGFLT3HPRD
Y240PDHQYyNDFPGSRCHPRD
Y520TTPGQyVLTGLSH2PhosphoSitePlus
Y318FDDPSyVNVQNFLT3HPRD
Y427FDDPSyVNVQNInsRRegPhos
Y350PDHQYyNDFPGFLT4phosphoELM; RegPhos
Y318FDDPSyVNVQNFYNHPRD
T145FVNKPtRGWLHHPRD
Y350PDHQYyNDFPGZAP70HPRD; phosphoELM; RegPhos
S426LFDDPsYVNVQPhosphoSitePlus; HPRD; phosphoELM
Y350PDHQYyNDFPGPhosphoSitePlus; phosphoELM; RegPhos
Y239PPDHQyYNDFPSYKHPRD
Y318FDDPSyVNVQNINSRHPRD
Y350PDHQYyNDFPGSYKHPRD; phosphoELM; RegPhos
Y240PDHQYyNDFPGZAP70HPRD
Y349PPDHQyYNDFPSykRegPhos
S139WTRHGsFVNKPPRKCAHPRD
S139WTRHGsFVNKPPKCaRegPhos
Y349PPDHQyYNDFPFLT4phosphoELM; RegPhos
Y427FDDPSyVNVQNSYKphosphoELM
T35FVNKPtRGWLHHPRD
Y239PPDHQyYNDFPFLT3HPRD
Y349PPDHQyYNDFPPhosphoSitePlus; phosphoELM; RegPhos
S317LFDDPsYVNVQHPRD
S139WTRHGsFVNKPPhosphoSitePlus; phosphoELM; RegPhos
Y349PPDHQyYNDFPSRCHPRD; RegPhos
Y318FDDPSyVNVQNLCKHPRD
Y427FDDPSyVNVQNLckRegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y349EEPPDHQyYNDFPGKPTPN2HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000401303P417ACOSMICMelanoma21499247
ENSP00000357438P307ACOSMICMelanoma21499247
ENSP00000401303A87VCOSMICOvarian Cancer21720365
ENSP00000357435*474GCOSMICOvarian Cancer21720365
ENSP00000357438F202SCOSMICLung Cancer18948947

Differential expressed protein
SHC1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SHC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG13_HUMANSHC1_HUMANGprotein -> effectorgpDB
GBG3_HUMANSHC1_HUMANGprotein -> effectorgpDB
GBG5_HUMANSHC1_HUMANGprotein -> effectorgpDB
GBG1_HUMANSHC1_HUMANGprotein -> effectorgpDB
GBB2_HUMANSHC1_HUMANGprotein -> effectorgpDB
GBG8_HUMANSHC1_HUMANGprotein -> effectorgpDB
GBG10_HUMANSHC1_HUMANGprotein -> effectorgpDB
GBG12_HUMANSHC1_HUMANGprotein -> effectorgpDB
GBB5_HUMANSHC1_HUMANGprotein -> effectorgpDB
GBB3_HUMANSHC1_HUMANGprotein -> effectorgpDB
GBB1_HUMANSHC1_HUMANGprotein -> effectorgpDB
GBG2_HUMANSHC1_HUMANGprotein -> effectorgpDB
GBG11_HUMANSHC1_HUMANGprotein -> effectorgpDB
PGFRB_HUMANSHC1_HUMANkinase -> substrateRegPhos
LCK_HUMANSHC1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
INSR_HUMANSHC1_HUMANkinase -> substrateHPRD; RegPhos
KSYK_HUMANSHC1_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
SRC_HUMANSHC1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANSHC1_HUMANkinase -> substrateRegPhos
ZAP70_HUMANSHC1_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
FYN_HUMANSHC1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
FLT3_HUMANSHC1_HUMANkinase -> substrateRegPhos
SHC1_HUMANZAP70_HUMANkinase -> substrateHPRD
VGFR3_HUMANSHC1_HUMANkinase -> substrateRegPhos
KPCA_HUMANSHC1_HUMANkinase -> substrateHPRD
JAK1_HUMANSHC1_HUMANkinase -> substrateNetPath
PTN2_HUMANSHC1_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04012ErbB signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04910Insulin signaling pathway
hsa05214Glioma
hsa05220Chronic myeloid leukemia
hsa05100Bacterial invasion of epithelial cells
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa05034Alcoholism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004713protein tyrosine kinase activityTASmolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0008284positive regulation of cell proliferationNASbiological_process
GO:0005759mitochondrial matrixIEAcellular_component
GO:0046875ephrin receptor bindingIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0040008regulation of growthIEAbiological_process
GO:0007176regulation of epidermal growth factor-activated reTASbiological_process
GO:0016337cell-cell adhesionIEAbiological_process
GO:0030971receptor tyrosine kinase bindingIEAmolecular_function
GO:0001525angiogenesisIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0030968endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0070435Shc-EGFR complexISScellular_component
GO:0005543phospholipid bindingTASmolecular_function
GO:0005829cytosolTAScellular_component
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0005158insulin receptor bindingIPImolecular_function
GO:0005159insulin-like growth factor receptor bindingIPImolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0005068transmembrane receptor protein tyrosine kinase adaTASmolecular_function
GO:0005168neurotrophin TRKA receptor bindingIPImolecular_function
GO:0045740positive regulation of DNA replicationISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007507heart developmentIEAbiological_process
GO:0031532actin cytoskeleton reorganizationIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0005154epidermal growth factor receptor bindingISSmolecular_function
GO:0000187activation of MAPK activityIEAbiological_process
GO:0008286insulin receptor signaling pathwayISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006987activation of signaling protein activity involved TASbiological_process
GO:0000165MAPK cascadeIDAbiological_process


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