Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KCNB1_HUMAN
Description:potassium voltage-gated channel, Shab-related subfamily, member 1 [Source:HGNC Symbol;Acc:6231]
Location:chr20 q13.13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S656SFFIEsPKSSMRegPhos
Y128GIDEIyLESCCK_tetraPhosphoSitePlus
S15SRSTSsLPPEPPhosphoSitePlus
S12KHGSRsTSSLPRegPhos
T93HPGAFtSILNFK_tetraPhosphoSitePlus
S26MEIVRsKACSRPhosphoSitePlus
S800NHFESsPLPTSPhosphoSitePlus
T359KDEDDtKFKSIIon_transPhosphoSitePlus
S499TLSETsSSKSFKv2channelPhosphoSitePlus
S805SPLPTsPKFLRPhosphoSitePlus
S723VLSPEsSIYTTPhosphoSitePlus
Y128GIDEIyLESCCSRCHPRD; RegPhos
Y99SILNFyRTGRLK_tetraPhosphoSitePlus
T374WWATItMTTVGIon_transPhosphoSitePlus
S500LSETSsSKSFEKv2channelPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y128YWGIDEIyLESCCQAPTPREHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000360806T280ICOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000360806Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.3915169874

Hyperphosphorylation site
KCNB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SRC_HUMANKCNB1_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANKCNB1_HUMANkinase -> substrateRegPhos
PTPRE_HUMANKCNB1_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04742Taste transduction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0047485protein N-terminus bindingIEAmolecular_function
GO:0043025neuronal cell bodyIEAcellular_component
GO:0051259protein oligomerizationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005216ion channel activityIEAmolecular_function
GO:0015271outward rectifier potassium channel activityIEAmolecular_function
GO:0007268synaptic transmissionTASbiological_process
GO:0032809neuronal cell body membraneIEAcellular_component
GO:0045211postsynaptic membraneIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0030425dendriteIEAcellular_component
GO:0006813potassium ion transportIEAbiological_process
GO:0005251delayed rectifier potassium channel activityIEAmolecular_function
GO:0055085transmembrane transportIEAbiological_process
GO:0006112energy reserve metabolic processTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0008076voltage-gated potassium channel complexIEAcellular_component
GO:0050796regulation of insulin secretionTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0051260protein homooligomerizationIEAbiological_process
GO:0005251delayed rectifier potassium channel activityIBAmolecular_function
GO:0032590dendrite membraneIEAcellular_component
GO:0005249voltage-gated potassium channel activityIEAmolecular_function
GO:0006811ion transportIEAbiological_process


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