Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ERBB3_HUMAN
Description:v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [Source:HGNC Symbol;Acc:3431]
Location:chr12 q13.2
Node attribute:PPI(source); substrate; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y868DKQLLySEAKTPkinase_TyrPhosphoSitePlus
Y1260TPDEDyEYMNRPhosphoSitePlus; HPRD
Y1199DEEYEyMNRRRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S686LERGEsIEPLDPhosphoSitePlus; HPRD; SysPTM
Y1289ASEQGyEEMRAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y1197DEDEEyEYMNRPhosphoSitePlus; HPRD
Y1327AFDNPdYWHSRHPRD
Y1276GPGGDyAAMGAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y1307APHVHyARLKTPhosphoSitePlus
Y680RAMRRyLERGEPhosphoSitePlus
Y1132RGDSAyHSQRHPhosphoSitePlus
S1315LKTLRsLEATDPhosphoSitePlus
S1331PDYWHsRLFPKPhosphoSitePlus
T640VLIGKtHLTMAPhosphoSitePlus
Y1328FDNPDyWHSRLPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S869KQLLYsEAKTPPkinase_TyrPhosphoSitePlus
T1319RSLEAtDSAFDPhosphoSitePlus
Y1054SPSSGyMPMNQPhosphoSitePlus; HPRD
S1285GACPAsEQGYEPhosphoSitePlus
S844NVLLKsPSQVQPkinase_TyrPhosphoSitePlus
Y1262DEDYEyMNRQRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y1222LEELGyEYMDVPhosphoSitePlus; HPRD
Y1159EDVNGyVMPDTPhosphoSitePlus
T1164YVMPDtHLKGTPhosphoSitePlus
S846LLKSPsQVQVAPkinase_TyrPhosphoSitePlus
T873YSEAKtPIKWMCDK5HPRD; RegPhos
S1123RSRSRsPRPRGCDK5HPRD; RegPhos
S1147PVTPLsPPGLEPhosphoSitePlus

Dephosphorylation site
ERBB3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000267101D1194ECOSMICOvarian Cancer21720365
ENSP00000267101Y464CBIOMARTBreast Cancer21930507, 21930502
ENSP00000267101V104MGreenman2007, HPIOvarian Cancer17344846, 18428421
ENSP00000267101V438ICOSMICOvarian Cancer21720365
ENSP00000267101Q281HCOSMICBreast Cancer20668451
ENSP00000267101D297YBIOMARTBreast Cancer21930507, 21930502
ENSP00000267101G69RDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000267101E928GCOSMICBreast Cancer20668451
ENSP00000267101M91ICOSMICHead and Neck Cancer21798893
ENSP00000267101S1049GCOSMICMelanoma21499247
ENSP00000267101Q298*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000267101T389KCOSMICBreast Cancer20668451
ENSP00000267101V104LBIOMARTBreast Cancer21930507, 21930502
ENSP00000267101G284RDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000415753V104LBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000408340Breast CancerNormal vs. CancertissueUp1.416470630
ENSP00000408340Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y1289CPASEQGyEEMRAFQovarian cancer20227043PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
NRG2_HUMANERBB3_HUMANligand -> receptorHPMR
CDK5_HUMANERBB3_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANERBB3_HUMANkinase -> substrateRegPhos
ERBB3_HUMANPI3R5_HUMANotherKEGG
NRG2_HUMANERBB3_HUMANotherKEGG
NRG1_HUMANERBB3_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04144Endocytosis
hsa04020Calcium signaling pathway
hsa04012ErbB signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007162negative regulation of cell adhesionIDAbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaTASbiological_process
GO:0021545cranial nerve developmentIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0051402neuron apoptotic processIMPbiological_process
GO:0043235receptor complexISScellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0007422peripheral nervous system developmentISSbiological_process
GO:0030296protein tyrosine kinase activator activityIDAmolecular_function
GO:0007422peripheral nervous system developmentIEAbiological_process
GO:0014037Schwann cell differentiationIEAbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigISSbiological_process
GO:0004888transmembrane signaling receptor activityISSmolecular_function
GO:0042803protein homodimerization activityNASmolecular_function
GO:0007165signal transductionIDAbiological_process
GO:0014065phosphatidylinositol 3-kinase cascadeIDAbiological_process
GO:0046982protein heterodimerization activityIDAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0061098positive regulation of protein tyrosine kinase actIDAbiological_process
GO:0042127regulation of cell proliferationIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0007507heart developmentISSbiological_process
GO:0019838growth factor bindingIPImolecular_function
GO:0005615extracellular spaceIDAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0051048negative regulation of secretionIDAbiological_process
GO:0004716receptor signaling protein tyrosine kinase activitIEAmolecular_function
GO:0009968negative regulation of signal transductionIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0042060wound healingNASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0016323basolateral plasma membraneIDAcellular_component
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actIEAmolecular_function
GO:0016324apical plasma membraneIEAcellular_component
GO:0003197endocardial cushion developmentIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0016328lateral plasma membraneIEAcellular_component


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