Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SRS10_HUMAN
Description:serine/arginine-rich splicing factor 10 [Source:HGNC Symbol;Acc:16713]
Location:chr1 p36.11
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y136SRSFDyNYRRSHPRD
S259WTSPKsSGH__PhosphoSitePlus
S249RSRSKsRSRSWPhosphoSitePlus; HPRD; phosphoELM
S160RSRSHsDNDRPHPRD
S171KHRNRsFSRSKPhosphoSitePlus
S260TSPKSsGH___PhosphoSitePlus
S253KSRSRsWTSPKPhosphoSitePlus; HPRD
Y138SFDYNyRRSYSHPRD
S108NVYSSsRYDDYPhosphoSitePlus; HPRD; phosphoELM
S175RSFSRsKSNSRPhosphoSitePlus
S107RNVYSsSRYDDHPRD
S119DRYRRsRSRSYPhosphoSitePlus; HPRD
Y4__MSRyLRPPNPhosphoSitePlus
S160RSRSHsDNDRFPhosphoSitePlus; HPRD; phosphoELM
S156GRPRRsRSHSDPhosphoSitePlus; HPRD; phosphoELM
S121YRRSRsRSYERPhosphoSitePlus; HPRD
S201RSRSAsHTKTRPhosphoSitePlus
Y110YSSSRyDDYDRPhosphoSitePlus; HPRD; phosphoELM
S259WTSPKsSHPRD
S235KEPPRsKSQSRPhosphoSitePlus; HPRD; phosphoELM
S141YNYRRsYSPRNHPRD
Y105EGRNVySSSRYHPRD
S173RNRSFsRSKSNPhosphoSitePlus
S251RSKSRsRSWTSPhosphoSitePlus; HPRD
Y113SRYDDyDRYRRPhosphoSitePlus
T255RSRSWtSPKSSPhosphoSitePlus; HPRD
S133RSRSRsFDYNYPhosphoSitePlus; HPRD; phosphoELM
S158PRRSRsHSDNDPhosphoSitePlus; HPRD; phosphoELM
S106GRNVYsSSRYDPhosphoSitePlus; HPRD; phosphoELM
S256SRSWTsPKSSGPhosphoSitePlus
S256SRSWTsPKSSHPRD
S129YERRRsRSRSFPhosphoSitePlus; HPRD; phosphoELM
S123RSRSRsYERRRPhosphoSitePlus; HPRD
Y40PIVDVyVPLDFRRM_1PhosphoSitePlus
S131RRRSRsRSFDYPhosphoSitePlus; HPRD; phosphoELM
S143YRRSYsPRNSRHPRD

Dephosphorylation site
SRS10_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363576E82QBIOMARTBreast Cancer21930507, 21930502
ENSP00000344149E82QBIOMARTBreast Cancer21930507, 21930502
ENSP00000342913E82QBIOMARTBreast Cancer21930507, 21930502
ENSP00000420195E82QBIOMARTBreast Cancer21930507, 21930502
ENSP00000363576*174RCOSMICSkin Cancer21984974

Differential expressed protein
SRS10_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SRS10_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PK3C3_HUMANSRS10_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANSRS10_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANSRS10_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANSRS10_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SRS10_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0005654nucleoplasmIDAcellular_component
GO:0000398mRNA splicing, via spliceosomeIDAbiological_process
GO:0006406mRNA export from nucleusNASbiological_process
GO:0006355regulation of transcription, DNA-dependentNASbiological_process
GO:0051082unfolded protein bindingNASmolecular_function
GO:0050733RS domain bindingNASmolecular_function
GO:0000166nucleotide bindingIEAmolecular_function
GO:0048025negative regulation of mRNA splicing, via spliceosIDAbiological_process
GO:0005634nucleusICcellular_component
GO:0003723RNA bindingNASmolecular_function
GO:0005737cytoplasmNAScellular_component
GO:0016482cytoplasmic transportIDAbiological_process
GO:0000375RNA splicing, via transesterification reactionsIDAbiological_process
GO:0016607nuclear speckIEAcellular_component
GO:0000244assembly of spliceosomal tri-snRNPNASbiological_process
GO:0006376mRNA splice site selectionIDAbiological_process
GO:0005515protein bindingIPImolecular_function


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