| UniProt/SwissProt ID: | MEF2D_HUMAN |
| Description: | myocyte enhancer factor 2D [Source:HGNC Symbol;Acc:6997] |
| Location: | chr1 q22 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y117 | LLEDKyRRASE | HJURP_C | PhosphoSitePlus |
| S444 | KSEPVsPSRER | CDK5 | RegPhos |
| S227 | GNGYVsARASP | PhosphoSitePlus | |
| Y117 | LLEDKyRRASE | HPRD | |
| S106 | PDGEDsLEQSP | HJURP_C | PhosphoSitePlus |
| S180 | DPRLLsPQQPA | MAPK7 | HPRD |
| S231 | VSARAsPGLLP | PhosphoSitePlus; HPRD; phosphoELM | |
| T517 | RMRLDtWT | HPRD | |
| S110 | DSLEQsPLLED | HJURP_C | PhosphoSitePlus |
| S98 | FNGCDsPEPDG | HJURP_C | PhosphoSitePlus |
| S180 | DPRLLsPQQPA | PhosphoSitePlus; phosphoELM; RegPhos | |
| S180 | DPRLLsPQQPA | Erk5 | RegPhos |
| S98 | FNGCDsPEPDG | HPRD; phosphoELM; RegPhos | |
| S201 | PQRPAsAGAML | PhosphoSitePlus | |
| S242 | VANGNsLNKVI | PhosphoSitePlus | |
| S110 | DSLEQsPLLED | HPRD; phosphoELM; RegPhos | |
| S121 | KYRRAsEELDG | HJURP_C | PhosphoSitePlus |
| S219 | NGACPsPVGNG | PhosphoSitePlus | |
| S192 | QRNSVsPGLPQ | PhosphoSitePlus; HPRD | |
| S251 | VIPAKsPPPPT | PhosphoSitePlus; HPRD; phosphoELM | |
| S121 | KYRRAsEELDG | HPRD; phosphoELM | |
| S446 | EPVSPsRERSP | Pex14_N | PhosphoSitePlus |
| S444 | KSEPVsPSRER | Pex14_N | PhosphoSitePlus |
| S212 | GGDLNsANGAC | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| T256 | SPPPPtHSTQL | PhosphoSitePlus | |
| S106 | PDGEDsLEQSP | HPRD; phosphoELM; RegPhos | |
| T517 | RMRLDtWTLK_ | PhosphoSitePlus | |
| Dephosphorylation site |
| MEF2D_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000271555 | T80S | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| MEF2D_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MEF2D_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK5_HUMAN | MEF2D_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | MEF2D_HUMAN | kinase -> substrate | RegPhos |
| MK07_HUMAN | MEF2D_HUMAN | kinase -> substrate | HPRD |
| MEF2D_HUMAN | PRVA_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| MEF2D_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006366 | transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0000977 | RNA polymerase II regulatory region sequence-speci | IDA | molecular_function |
| GO:0033613 | activating transcription factor binding | IPI | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0002062 | chondrocyte differentiation | IEA | biological_process |
| GO:0007512 | adult heart development | IEP | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0000981 | sequence-specific DNA binding RNA polymerase II tr | IDA | molecular_function |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0007399 | nervous system development | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0001958 | endochondral ossification | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0007517 | muscle organ development | TAS | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | NAS | molecular_function |
| GO:0042826 | histone deacetylase binding | IPI | molecular_function |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0046983 | protein dimerization activity | IEA | molecular_function |
| GO:0045944 | positive regulation of transcription from RNA poly | IDA | biological_process |
| GO:0001649 | osteoblast differentiation | IEA | biological_process |