Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MEF2D_HUMAN
Description:myocyte enhancer factor 2D [Source:HGNC Symbol;Acc:6997]
Location:chr1 q22
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y117LLEDKyRRASEHJURP_CPhosphoSitePlus
S444KSEPVsPSRERCDK5RegPhos
S227GNGYVsARASPPhosphoSitePlus
Y117LLEDKyRRASEHPRD
S106PDGEDsLEQSPHJURP_CPhosphoSitePlus
S180DPRLLsPQQPAMAPK7HPRD
S231VSARAsPGLLPPhosphoSitePlus; HPRD; phosphoELM
T517RMRLDtWTHPRD
S110DSLEQsPLLEDHJURP_CPhosphoSitePlus
S98FNGCDsPEPDGHJURP_CPhosphoSitePlus
S180DPRLLsPQQPAPhosphoSitePlus; phosphoELM; RegPhos
S180DPRLLsPQQPAErk5RegPhos
S98FNGCDsPEPDGHPRD; phosphoELM; RegPhos
S201PQRPAsAGAMLPhosphoSitePlus
S242VANGNsLNKVIPhosphoSitePlus
S110DSLEQsPLLEDHPRD; phosphoELM; RegPhos
S121KYRRAsEELDGHJURP_CPhosphoSitePlus
S219NGACPsPVGNGPhosphoSitePlus
S192QRNSVsPGLPQPhosphoSitePlus; HPRD
S251VIPAKsPPPPTPhosphoSitePlus; HPRD; phosphoELM
S121KYRRAsEELDGHPRD; phosphoELM
S446EPVSPsRERSPPex14_NPhosphoSitePlus
S444KSEPVsPSRERPex14_NPhosphoSitePlus
S212GGDLNsANGACPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T256SPPPPtHSTQLPhosphoSitePlus
S106PDGEDsLEQSPHPRD; phosphoELM; RegPhos
T517RMRLDtWTLK_PhosphoSitePlus

Dephosphorylation site
MEF2D_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000271555T80SCOSMICOvarian Cancer21720365

Differential expressed protein
MEF2D_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MEF2D_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK5_HUMANMEF2D_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANMEF2D_HUMANkinase -> substrateRegPhos
MK07_HUMANMEF2D_HUMANkinase -> substrateHPRD
MEF2D_HUMANPRVA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
MEF2D_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006366transcription from RNA polymerase II promoterIDAbiological_process
GO:0000977RNA polymerase II regulatory region sequence-speciIDAmolecular_function
GO:0033613activating transcription factor bindingIPImolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0002062chondrocyte differentiationIEAbiological_process
GO:0007512adult heart developmentIEPbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0000981sequence-specific DNA binding RNA polymerase II trIDAmolecular_function
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0007399nervous system developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0001958endochondral ossificationIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0007517muscle organ developmentTASbiological_process
GO:0003700sequence-specific DNA binding transcription factorNASmolecular_function
GO:0042826histone deacetylase bindingIPImolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0001649osteoblast differentiationIEAbiological_process


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