| UniProt/SwissProt ID: | SMYD2_HUMAN |
| Description: | SET and MYND domain containing 2 [Source:HGNC Symbol;Acc:20982] |
| Location: | chr1 q32.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y377 | KHYPLySLNVA | TPR_12 | PhosphoSitePlus |
| S35 | GDLLFsCPAYA | SET | PhosphoSitePlus |
| T44 | YAYVLtVNERG | SET | PhosphoSitePlus |
| Dephosphorylation site |
| SMYD2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000355924 | *434Y | COSMIC | Ovarian Cancer | 20826764 | ENSP00000355924 | E144K | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| SMYD2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SMYD2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FAK1_HUMAN | SMYD2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK5_HUMAN | SMYD2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | SMYD2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SMYD2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0002039 | p53 binding | IPI | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0046975 | histone methyltransferase activity (H3-K36 specifi | IEA | molecular_function |
| GO:0005737 | cytoplasm | ISS | cellular_component |
| GO:0000122 | negative regulation of transcription from RNA poly | IMP | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0000993 | RNA polymerase II core binding | IEA | molecular_function |
| GO:0008285 | negative regulation of cell proliferation | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0016279 | protein-lysine N-methyltransferase activity | IDA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0043516 | regulation of DNA damage response, signal transduc | IMP | biological_process |
| GO:0018026 | peptidyl-lysine monomethylation | IDA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0018027 | peptidyl-lysine dimethylation | IEA | biological_process |
| GO:0010452 | histone H3-K36 methylation | IEA | biological_process |