Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HES1_HUMAN
Description:hairy and enhancer of split 1, (Drosophila) [Source:HGNC Symbol;Acc:5192]
Location:chr3 q29
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S37SEHRKsSKPIMPRKCAHPRD
S38EHRKSsKPIMEPRKCAHPRD
S37SEHRKsSKPIMPKCaRegPhos
S38EHRKSsKPIMEPKCaRegPhos
S10IMEKNsSSPVAHPRD
S37SEHRKsSKPIMPKC_groupphosphoELM; RegPhos
S32KPKTAsEHRKSPhosphoSitePlus
S38EHRKSsKPIMEHLHPhosphoSitePlus
S38EHRKSsKPIMEPKC_groupphosphoELM; RegPhos
T59LSQLKtLILDAHLHPhosphoSitePlus
S55INESLsQLKTLHLHPhosphoSitePlus
S37SEHRKsSKPIMHLHPhosphoSitePlus
T24ASVNTtPDKPKPhosphoSitePlus; HPRD

Dephosphorylation site
HES1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000232424A271VCOSMICOvarian Cancer21720365
ENSP00000232424A271VTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
HES1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HES1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK5_HUMANHES1_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANHES1_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANHES1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANHES1_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANHES1_HUMANkinase -> substrateHPRD
RBPJL_HUMANHES1_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04330Notch signaling pathway
hsa04950Maturity onset diabetes of the young
hsa03460Fanconi anemia pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042491auditory receptor cell differentiationIEAbiological_process
GO:0006461protein complex assemblyIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0021557oculomotor nerve developmentIEAbiological_process
GO:0021558trochlear nerve developmentIEAbiological_process
GO:2000981negative regulation of inner ear receptor cell difIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0097084vascular smooth muscle cell developmentISSbiological_process
GO:2000227negative regulation of pancreatic A cell differentIEAbiological_process
GO:0048715negative regulation of oligodendrocyte differentiaIEAbiological_process
GO:0003266regulation of secondary heart field cardioblast prIEAbiological_process
GO:0003281ventricular septum developmentIEAbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0021984adenohypophysis developmentIEAbiological_process
GO:0048667cell morphogenesis involved in neuron differentiatIEAbiological_process
GO:0006461protein complex assemblyISSbiological_process
GO:0003266regulation of secondary heart field cardioblast prISSbiological_process
GO:0045977positive regulation of mitotic cell cycle, embryonISSbiological_process
GO:0007219Notch signaling pathwayIDAbiological_process
GO:0045608negative regulation of auditory receptor cell diffIEAbiological_process
GO:0097084vascular smooth muscle cell developmentIEAbiological_process
GO:0021555midbrain-hindbrain boundary morphogenesisIEAbiological_process
GO:0048505regulation of timing of cell differentiationIEAbiological_process
GO:0060412ventricular septum morphogenesisISSbiological_process
GO:0043565sequence-specific DNA bindingISSmolecular_function
GO:0060253negative regulation of glial cell proliferationIEAbiological_process
GO:0007262STAT protein import into nucleusIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0048538thymus developmentIEAbiological_process
GO:0048711positive regulation of astrocyte differentiationISSbiological_process
GO:0030513positive regulation of BMP signaling pathwayIEAbiological_process
GO:0016477cell migrationIEAbiological_process
GO:0048538thymus developmentISSbiological_process
GO:0072141renal interstitial cell developmentIEAbiological_process
GO:0003151outflow tract morphogenesisISSbiological_process
GO:0021537telencephalon developmentIEAbiological_process
GO:0072049comma-shaped body morphogenesisIEAbiological_process
GO:0050767regulation of neurogenesisIEAbiological_process
GO:0061309cardiac neural crest cell development involved in IEAbiological_process
GO:0045596negative regulation of cell differentiationIEAbiological_process
GO:0042517positive regulation of tyrosine phosphorylation ofISSbiological_process
GO:0060716labyrinthine layer blood vessel developmentIEAbiological_process
GO:0042826histone deacetylase bindingIPImolecular_function
GO:0071820N-box bindingISSmolecular_function
GO:2000978negative regulation of forebrain neuron differentiISSbiological_process
GO:0000981sequence-specific DNA binding RNA polymerase II trIEAmolecular_function
GO:0045977positive regulation of mitotic cell cycle, embryonIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0097150neuronal stem cell maintenanceIEAbiological_process
GO:0035910ascending aorta morphogenesisISSbiological_process
GO:0060675ureteric bud morphogenesisIEAbiological_process
GO:0045747positive regulation of Notch signaling pathwayIEAbiological_process
GO:0060037pharyngeal system developmentISSbiological_process
GO:0007399nervous system developmentTASbiological_process
GO:0061009common bile duct developmentIEAbiological_process
GO:0021983pituitary gland developmentIEAbiological_process
GO:0048711positive regulation of astrocyte differentiationIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0031016pancreas developmentIEAbiological_process
GO:0043388positive regulation of DNA bindingISSbiological_process
GO:0003143embryonic heart tube morphogenesisIEAbiological_process
GO:0046427positive regulation of JAK-STAT cascadeISSbiological_process
GO:0006366transcription from RNA polymerase II promoterIEAbiological_process
GO:0061106negative regulation of stomach neuroendocrine cellIEAbiological_process
GO:0035019somatic stem cell maintenanceIEAbiological_process
GO:0042517positive regulation of tyrosine phosphorylation ofIEAbiological_process
GO:0035909aorta morphogenesisIEAbiological_process
GO:0060164regulation of timing of neuron differentiationIEAbiological_process
GO:0042803protein homodimerization activityISSmolecular_function
GO:0071820N-box bindingIEAmolecular_function
GO:0035910ascending aorta morphogenesisIEAbiological_process
GO:0042668auditory receptor cell fate determinationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0048715negative regulation of oligodendrocyte differentiaISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0090102cochlea developmentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0060253negative regulation of glial cell proliferationISSbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0021575hindbrain morphogenesisIEAbiological_process
GO:0072050S-shaped body morphogenesisIEAbiological_process
GO:0060037pharyngeal system developmentIEAbiological_process
GO:0061309cardiac neural crest cell development involved in ISSbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0021861forebrain radial glial cell differentiationISSbiological_process
GO:0048844artery morphogenesisIEAbiological_process
GO:0001078RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0045165cell fate commitmentIEAbiological_process
GO:0072012glomerulus vasculature developmentIEAbiological_process
GO:0003143embryonic heart tube morphogenesisISSbiological_process
GO:0046331lateral inhibitionIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0007262STAT protein import into nucleusISSbiological_process
GO:0072282metanephric nephron tubule morphogenesisIEAbiological_process
GO:0042102positive regulation of T cell proliferationIEAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0003151outflow tract morphogenesisIEAbiological_process
GO:0045665negative regulation of neuron differentiationIEAbiological_process
GO:0008134transcription factor bindingNASmolecular_function
GO:0007155cell adhesionIEAbiological_process
GO:0007389pattern specification processIEAbiological_process
GO:2000974negative regulation of pro-B cell differentiationIMPbiological_process
GO:0048469cell maturationIEAbiological_process
GO:0043388positive regulation of DNA bindingIEAbiological_process
GO:0046427positive regulation of JAK-STAT cascadeIEAbiological_process
GO:0001889liver developmentIEAbiological_process
GO:0060412ventricular septum morphogenesisIEAbiological_process
GO:0007224smoothened signaling pathwayIEAbiological_process
GO:2000737negative regulation of stem cell differentiationIMPbiological_process
GO:0003281ventricular septum developmentISSbiological_process
GO:0045598regulation of fat cell differentiationIEAbiological_process
GO:0008284positive regulation of cell proliferationISSbiological_process
GO:0005634nucleusISScellular_component
GO:0030901midbrain developmentIEAbiological_process
GO:0097150neuronal stem cell maintenanceIEPbiological_process
GO:0031018endocrine pancreas developmentTASbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0021915neural tube developmentIEAbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0001078RNA polymerase II core promoter proximal region seISSmolecular_function
GO:0048844artery morphogenesisISSbiological_process