Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FYN_HUMAN
Description:FYN oncogene related to SRC, FGR, YES [Source:HGNC Symbol;Acc:4037]
Location:chr6 q21
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y91LFVALyDYEARSH3_1; YcaOPhosphoSitePlus
S257RLTDLsVKTKDPhosphoSitePlus; HPRD; SysPTM
Y28NQSSGyRYGTDPhosphoSitePlus
S21EERDGsLNQSSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y440PEAALyGRFTIPkinase_TyrPhosphoSitePlus
Y28NQSSGyRYGTDFynphosphoELM; RegPhos
Y185TTKGAySLSIRHPRD; RegPhos
S26SLNQSsGYRYGPhosphoSitePlus
Y531ATEPQyQPGECskphosphoELM; SysPTM
Y531ATEPQyQPGENPhosphoSitePlus; RegPhos; SysPTM
T217GYYITtRAQFESH2PhosphoSitePlus
Y531ATEPQyQPGECSKHPRD; SysPTM
Y531ATEPQyQPGENCskRegPhos; SysPTM
Y420IEDNEyTARQGphosphoELM; SysPTM
T300KVAIKtLKPGTPkinase_TyrPhosphoSitePlus
Y39PTPQHyPSFGVFYNHPRD; RegPhos
Y420IEDNEyTARQGautocatalysisRegPhos; SysPTM
Y39PTPQHyPSFGVFynphosphoELM; RegPhos
Y531ATEPQyQPGENCSKRegPhos; SysPTM
Y420IEDNEyTARQGFynphosphoELM; RegPhos; SysPTM
Y214DNGGYyITTRASH2PhosphoSitePlus
Y417IEDNEyTARQGFYNHPRD
Y420IEDNEyTARQGFYNHPRD; RegPhos; SysPTM
T294TWNGNtKVAIKPkinase_TyrPhosphoSitePlus
S25GSLNQsSGYRYPhosphoSitePlus; HPRD; SysPTM
Y28NQSSGyRYGTDPDGFR_betaphosphoELM
T522LEDYFtATEPQHPRD
T470LEDYFtATEPQHPRD
Y28NQSSGyRYGTDPDGFRbRegPhos
Y440PEAALyGRFTIphosphoELM
S178FLIREsETTKGSH2PhosphoSitePlus
S307KPGTMsPESFLPkinase_TyrPhosphoSitePlus
Y213LDNGGyYITTRSH2PhosphoSitePlus
T509PEERPtFEYLQHPRD
Y185TTKGAySLSIRSH2PhosphoSitePlus
T12KDKEAtKLTEEPKC_groupRegPhos
Y39PTPQHyPSFGVPhosphoSitePlus
T181RESETtKGAYSSH2PhosphoSitePlus
T421EDNEYtARQGAPkinase_TyrPhosphoSitePlus
T12KDKEAtKLTEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y420IEDNEyTARQGPkinase_TyrPhosphoSitePlus; SysPTM
Y214DNGGYyITTRAHPRD; phosphoELM; RegPhos
T457PEERPtFEYLQHPRD
T525LEDYFtATEPQPhosphoSitePlus; HPRD
Y365IEDNEyTARQGFYNHPRD
Y476ATEPQyQPGECSKHPRD
Y528ATEPQyQPGECSKHPRD
Y28NQSSGyRYGTDPDGFRBHPRD
Y30SSGYRyGTDPTFynphosphoELM; RegPhos
Y30SSGYRyGTDPTPhosphoSitePlus
Y213LDNGGyYITTRHPRD; phosphoELM
Y30SSGYRyGTDPTFYNHPRD; RegPhos
T527DYFTAtEPQYQPhosphoSitePlus
S188GAYSLsIRDWDSH2PhosphoSitePlus
T289EVWMGtWNGNTPkinase_TyrPhosphoSitePlus
S186TKGAYsLSIRDSH2PhosphoSitePlus
Y339SEEPIyIVTEYPkinase_TyrPhosphoSitePlus
T512PEERPtFEYLQHPRD

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y365RLIEDNEyTARQGAKPTPN5HPRD
Y420RLIEDNEyTARQGAKPTPN18HPRD
Y528FTATEPQyQPGENLPTPRCHPRD
Y528FTATEPQyQPGENLPTPRAHPRD
Y420RLIEDNEyTARQGAKPTPN5HPRD
Y417RLIEDNEyTARQGAKPTPN5HPRD
Y476FTATEPQyQPGENLPTPRCHPRD
Y476FTATEPQyQPGENLPTPRAHPRD
Y531FTATEPQyQPGENLPTPRAHPRD
Y531FTATEPQyQPGENLPTPRCHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000357656W290*Greenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000357656G410RGreenman2007Skin Cancer17344846, 18428421
ENSP00000357656V243LGreenman2007, HPILung Cancer17344846, 18428421
ENSP00000357671G255VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000357656W290*Greenman2007Neoplasms by Histologic Type16618716, 17344846, 18428421

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000357667Uterine CancerNormal vs. Cancercell lineUp2515838902

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y420Pkinase_TyrRLIEDNEyTARQGAKcancer, squamous cell carcinoma19934324PhosphoSitePlus
Y420Pkinase_TyrRLIEDNEyTARQGAKbreast cancer20855525PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
FYN_HUMANTXK_HUMANkinase -> substrateHPRD; RegPhos; NetPath
FYN_HUMANCD3Z_HUMANkinase -> substrateKEGG; NetPath; Robert H Newman (2013)
KPCA_HUMANFYN_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANACK1_HUMANkinase -> substrateHPRD; RegPhos
FYN_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANVAV_HUMANkinase -> substrateNetPath
FYN_HUMANSKAP1_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
FYN_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANCNN1_HUMANkinase -> substrateHPRD
FYN_HUMANMK07_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANTGFI1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
FYN_HUMANWASP_HUMANkinase -> substrateNetPath
FYN_HUMANLCP2_HUMANkinase -> substrateNetPath
FYN_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANGAB2_HUMANkinase -> substrateKEGG
FYN_HUMANCNN3_HUMANkinase -> substrateHPRD; RegPhos
FYN_HUMANP85A_HUMANkinase -> substrateNetPath
FYN_HUMANCDK5_HUMANkinase -> substrateHPRD; RegPhos
FYN_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANPTPRF_HUMANkinase -> substrateHPRD
FYN_HUMANITCH_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANKSYK_HUMANkinase -> substrateNetPath
FYN_HUMANSLAF1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
FYN_HUMANRHG33_HUMANkinase -> substrateHPRD; RegPhos
FYN_HUMANPHAG1_HUMANkinase -> substrateRegPhos
FYN_HUMANCD79A_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
FYN_HUMANPLAK_HUMANkinase -> substrateRegPhos
FYN_HUMANSIT1_HUMANkinase -> substrateNetPath
FYN_HUMANTM1L1_HUMANkinase -> substrateHPRD; RegPhos
FYN_HUMANCBL_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
FYN_HUMANMAP2_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANTUT4_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANSHC1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
FYN_HUMANNMDE2_HUMANkinase -> substrateRegPhos
FYN_HUMANTRAT1_HUMANkinase -> substrateNetPath
FYN_HUMANSRA1_HUMANkinase -> substrateRobert H Newman (2013)
PGFRB_HUMANFYN_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
FYN_HUMANUB2L3_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANFYN_HUMANkinase -> substrateRegPhos
FYN_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANFYN_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANPLCG2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANFYN_HUMANkinase -> substrateRegPhos
FYN_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANCTNB1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
FYN_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANT22D3_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANCD3E_HUMANkinase -> substrateKEGG
FYN_HUMANBFAR_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANCTLA4_HUMANkinase -> substrateHPRD; RegPhos; NetPath
FYN_HUMANCD79B_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
FYN_HUMANMAG_HUMANkinase -> substrateHPRD
FYN_HUMANSYUA_HUMANkinase -> substrateHPRD; RegPhos
FYN_HUMANGRB10_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
FYN_HUMANKIT_HUMANkinase -> substrateNetPath
FYN_HUMANSHC2_HUMANkinase -> substrateKEGG
FYN_HUMANCD5_HUMANkinase -> substrateRegPhos
FYN_HUMANCLM7_HUMANkinase -> substrateRegPhos
FYN_HUMANFYB_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
FYN_HUMANFCG2A_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
FYN_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANCAV1_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANFYN_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
FYN_HUMANPPAC_HUMANkinase -> substrateRegPhos
FYN_HUMANNMT1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
FYN_HUMANITPR1_HUMANkinase -> substrateHPRD; RegPhos; NetPath; Robert H Newman (2013)
PTPRC_HUMANFYN_HUMANphosphatase -> substrateHPRD; KEGG
PTN18_HUMANFYN_HUMANphosphatase -> substrateHPRD
PTN5_HUMANFYN_HUMANphosphatase -> substrateHPRD
PTPRA_HUMANFYN_HUMANphosphatase -> substrateHPRD
CAV1_HUMANFYN_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04725Cholinergic synapse
hsa04360Axon guidance
hsa04520Adherens junction
hsa05130Pathogenic Escherichia coli infection
hsa04380Osteoclast differentiation
hsa05162Measles
hsa05020Prion diseases
hsa04664Fc epsilon RI signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04510Focal adhesion
hsa04660T cell receptor signaling pathway
hsa05416Viral myocarditis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0007411axon guidanceTASbiological_process
GO:0001948glycoprotein bindingIEAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0042610CD8 receptor bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0042493response to drugIEAbiological_process
GO:0046875ephrin receptor bindingIPImolecular_function
GO:0045471response to ethanolIEAbiological_process
GO:0006816calcium ion transportNASbiological_process
GO:0050852T cell receptor signaling pathwayIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0050690regulation of defense response to virus by virusTASbiological_process
GO:0043548phosphatidylinositol 3-kinase bindingIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0007612learningTASbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0042177negative regulation of protein catabolic processIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0007243intracellular protein kinase cascadeTASbiological_process
GO:0015631tubulin bindingIEAmolecular_function
GO:0042608T cell receptor bindingIEAmolecular_function
GO:0071375cellular response to peptide hormone stimulusIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0050798activated T cell proliferationIEAbiological_process
GO:0050966detection of mechanical stimulus involved in sensoIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0048813dendrite morphogenesisIEAbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0050900leukocyte migrationTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0001764neuron migrationIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0051428peptide hormone receptor bindingIEAmolecular_function
GO:0016032viral reproductionTASbiological_process
GO:0007631feeding behaviorTASbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0005768endosomeIDAcellular_component
GO:0004715non-membrane spanning protein tyrosine kinase actiNASmolecular_function
GO:0042802identical protein bindingIPImolecular_function
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0006468protein phosphorylationNASbiological_process
GO:0044325ion channel bindingIEAmolecular_function
GO:2001240negative regulation of extrinsic apoptotic signaliIEAbiological_process
GO:0008360regulation of cell shapeIEAbiological_process
GO:0042609CD4 receptor bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0010976positive regulation of neuron projection developmeIEAbiological_process
GO:0014069postsynaptic densityIEAcellular_component