| UniProt/SwissProt ID: | DCX_HUMAN |
| Description: | doublecortin [Source:HGNC Symbol;Acc:2714] |
| Location: | chrX q23 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T336 | QSPIStPTSPG | CDK5 | HPRD |
| S339 | KTSAKsPGPMR | phosphoELM; RegPhos | |
| S307 | AQDDFsLDENE | CK2_group | RegPhos |
| T326 | SSQLStPKSKQ | CDK5 | HPRD |
| T370 | PKASPtPQKTS | CDK5 | HPRD |
| S320 | DANGTsSSQLS | HPRD | |
| Y145 | RNGDRyFKGIV | PhosphoSitePlus | |
| T303 | AIKLEtGVVKK | DCX | PhosphoSitePlus |
| T412 | QSPIStPTSPG | CDK5 | HPRD |
| S109 | MNGLPsPTHSA | CDK5 | HPRD |
| T331 | PKASPtPQKTS | CDK5 | RegPhos |
| T402 | SSQLStPKSKQ | CDK5 | HPRD |
| S408 | PKSKQsPISTP | CDK5 | HPRD |
| S89 | TLQALsNEKKA | phosphoELM; RegPhos | |
| S415 | ISTPTsPGSLR | PhosphoSitePlus | |
| S28 | MNGLPsPTHSA | CDK5 | HPRD |
| S348 | MRRSKsPADSA | CK2_group | RegPhos |
| S157 | SRKIGsMDELE | CK2_group | RegPhos |
| Y186 | GVRYIyTIDGS | DCX | PhosphoSitePlus |
| S357 | SANGTsSSQLS | RegPhos | |
| S152 | YTIDGsRKIGS | PKC_group | RegPhos |
| S70 | MNGLPsPTHSA | CDK5 | RegPhos |
| S376 | ISTPTsPGSLR | CDK5 | RegPhos |
| S359 | NGTSSsQLSTP | RegPhos | |
| S346 | GPMRRsKSPAD | RegPhos | |
| S378 | KTSAKsPGPMR | PhosphoSitePlus | |
| S348 | MRRSKsPADSA | CDK5 | RegPhos |
| S132 | ADLTRsLSDNI | CK2_group | RegPhos |
| T111 | GLPSPtHSAHC | PhosphoSitePlus | |
| T363 | SSQLStPKSKQ | CDK5 | RegPhos |
| T363 | SSQLStPKSKQ | MAPK_group | RegPhos |
| S411 | KQSPIsTPTSP | PhosphoSitePlus; HPRD | |
| S287 | KKTAHsFEQVL | DCX | PhosphoSitePlus |
| T321 | SSQLStPKSKQ | CDK5 | HPRD |
| S405 | LSTPKsKQSPI | PhosphoSitePlus | |
| S109 | MNGLPsPTHSA | PhosphoSitePlus | |
| S334 | ISTPTsPGSLR | CDK5 | HPRD |
| S369 | PKSKQsPISTP | CDK5 | RegPhos |
| S332 | PKSKQsPISTP | CDK5 | HPRD |
| S315 | SANGTsSSQLS | HPRD | |
| S391 | LYLPLsLDDSD | CK2_group | RegPhos |
| S297 | KTSAKsPGPMR | CDK5 | HPRD |
| S397 | LDDSDsLGDSM | CK2_group | RegPhos |
| S335 | KQSPIsTPTSP | HPRD | |
| T373 | QSPIStPTSPG | MAPK_group | RegPhos |
| S306 | MRRSKsPADSA | CDK5 | HPRD |
| T289 | PKASPtPQKTS | CDK5 | HPRD |
| S368 | AGPKAsPTPQK | PhosphoSitePlus | |
| S306 | MRRSKsPADSG | CDK5 | HPRD |
| S339 | KTSAKsPGPMR | CDK5 | RegPhos |
| S379 | PTSPGsLRKHK | PKC_group | RegPhos |
| S415 | ISTPTsPGSLR | CDK5 | HPRD |
| S336 | TPQKTsAKSPG | PKC_group | RegPhos |
| Y184 | PQGVRyIYTID | DCX | PhosphoSitePlus |
| Y112 | FKGIVyAVSSD | ABL | RegPhos |
| S376 | ISTPTsPGSLR | MAPK_group | RegPhos |
| S329 | AGPKAsPTPQK | CDK5 | RegPhos |
| S408 | PKSKQsPISTP | PhosphoSitePlus | |
| S330 | KQSPIsTPTSP | HPRD | |
| Y112 | FKGIVyAVSSD | phosphoELM; RegPhos | |
| S128 | TLQALsNEKKA | PhosphoSitePlus | |
| S287 | AGPKAsPTPQK | CDK5 | HPRD |
| S369 | PKSKQsPISTP | MAPK_group | RegPhos |
| T373 | QSPIStPTSPG | CDK5 | RegPhos |
| S372 | KQSPIsTPTSP | phosphoELM; RegPhos | |
| S339 | ISTPTsPGSLR | CDK5 | HPRD |
| T363 | SSQLStPKSKQ | PKC_group | RegPhos |
| S378 | KTSAKsPGPMR | CDK5 | HPRD |
| S396 | SANGTsSSQLS | PhosphoSitePlus; HPRD | |
| T284 | LLNKKtAHSFE | DCX | PhosphoSitePlus |
| S327 | PKSKQsPISTP | CDK5 | HPRD |
| S116 | VYAVSsDRFRS | PKC_group | RegPhos |
| S368 | AGPKAsPTPQK | CDK5 | HPRD |
| S387 | MRRSKsPADSA | CDK5 | HPRD |
| S155 | VYAVSsDRFRS | DCX | PhosphoSitePlus |
| T56 | DERDKtSRNMR | PKC_group | RegPhos |
| T331 | QSPIStPTSPG | CDK5 | HPRD |
| S401 | SSSQLsTPKSK | PhosphoSitePlus | |
| Dephosphorylation site |
| DCX_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000337697 | T111N | COSMIC | Lung Cancer | ENSP00000337697 | S396Y | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000337697 | P409L | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000337697 | N393D | COSMIC | Skin Cancer | 21984974 | ENSP00000337697 | D256N | COSMIC | Melanoma | ENSP00000337697 | R339C | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| DCX_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DCX_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK5_HUMAN | DCX_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | DCX_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| DCX_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005874 | microtubule | IEA | cellular_component |
| GO:0021952 | central nervous system projection neuron axonogene | IEA | biological_process |
| GO:0005856 | cytoskeleton | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0043005 | neuron projection | IDA | cellular_component |
| GO:0001764 | neuron migration | IEA | biological_process |
| GO:0048675 | axon extension | IEA | biological_process |
| GO:0007417 | central nervous system development | TAS | biological_process |
| GO:0008017 | microtubule binding | IDA | molecular_function |
| GO:0048813 | dendrite morphogenesis | IEA | biological_process |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0007399 | nervous system development | TAS | biological_process |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0007420 | brain development | IEA | biological_process |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0005875 | microtubule associated complex | TAS | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |