| UniProt/SwissProt ID: | CIP4_HUMAN |
| Description: | thyroid hormone receptor interactor 10 [Source:HGNC Symbol;Acc:12304] |
| Location: | chr19 p13.3 |
| Node attribute: | substrate; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S426 | SNRGDsLSRHA | HPRD | |
| S335 | RPPPLsPLGGP | PhosphoSitePlus; phosphoELM | |
| S288 | EFEDFsQPMNR | PhosphoSitePlus | |
| S343 | GGPVPsALPNG | phosphoELM | |
| S304 | SLGTPsDGRPE | PhosphoSitePlus; HPRD; phosphoELM | |
| S428 | RGDSLsRHARP | HPRD | |
| Y471 | QDTPIyTEFDE | HPRD | |
| S482 | SNRGDsLSRHA | PhosphoSitePlus; phosphoELM | |
| S298 | RAPSDsSLGTP | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y190 | ESKNEyAAQLQ | PhosphoSitePlus | |
| S296 | MNRAPsDSSLG | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S299 | APSDSsLGTPS | PhosphoSitePlus; HPRD; phosphoELM | |
| T579 | KGDGWtRVRRK | SH3_1 | PhosphoSitePlus |
| S351 | PNGPPsPRSGR | PhosphoSitePlus; phosphoELM; SysPTM | |
| Y590 | EGGEGyVPTSY | SH3_1 | PhosphoSitePlus |
| T302 | DSSLGtPSDGR | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| CIP4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000320493 | D260N | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000320117 | Gastric Cancer | Treatment (none vs. drug-resistant) | cell line | Up | 1.3 | 20625496 |
| Hyperphosphorylation site |
| CIP4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FAK2_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PDPK1_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M3K7_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK2_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TGFR2_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMX_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK18_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCZ_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK5_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PTK6_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| LCK_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RET_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGR_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCT_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGFR2_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| EPHA3_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KSYK_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK09_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M3K19_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK10_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PXK_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1E_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC2_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6A2_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NRBP2_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK07_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GSK3B_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CIP4_HUMAN | GTR4_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04910 | Insulin signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030036 | actin cytoskeleton organization | NAS | biological_process |
| GO:0008289 | lipid binding | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006897 | endocytosis | IEA | biological_process |
| GO:0007264 | small GTPase mediated signal transduction | TAS | biological_process |
| GO:0005737 | cytoplasm | NAS | cellular_component |
| GO:0042995 | cell projection | IEA | cellular_component |
| GO:0051056 | regulation of small GTPase mediated signal transdu | TAS | biological_process |
| GO:0005856 | cytoskeleton | IEA | cellular_component |
| GO:0005938 | cell cortex | IEA | cellular_component |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0001891 | phagocytic cup | IEA | cellular_component |
| GO:0007154 | cell communication | NAS | biological_process |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0005764 | lysosome | IEA | cellular_component |
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