Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CIP4_HUMAN
Description:thyroid hormone receptor interactor 10 [Source:HGNC Symbol;Acc:12304]
Location:chr19 p13.3
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S426SNRGDsLSRHAHPRD
S335RPPPLsPLGGPPhosphoSitePlus; phosphoELM
S288EFEDFsQPMNRPhosphoSitePlus
S343GGPVPsALPNGphosphoELM
S304SLGTPsDGRPEPhosphoSitePlus; HPRD; phosphoELM
S428RGDSLsRHARPHPRD
Y471QDTPIyTEFDEHPRD
S482SNRGDsLSRHAPhosphoSitePlus; phosphoELM
S298RAPSDsSLGTPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y190ESKNEyAAQLQPhosphoSitePlus
S296MNRAPsDSSLGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S299APSDSsLGTPSPhosphoSitePlus; HPRD; phosphoELM
T579KGDGWtRVRRKSH3_1PhosphoSitePlus
S351PNGPPsPRSGRPhosphoSitePlus; phosphoELM; SysPTM
Y590EGGEGyVPTSYSH3_1PhosphoSitePlus
T302DSSLGtPSDGRPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
CIP4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000320493D260NTCGA, COSMICOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000320117Gastric CancerTreatment (none vs. drug-resistant)cell lineUp1.320625496

Hyperphosphorylation site
CIP4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FAK2_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
BMX_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
CDK18_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
RET_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
KPCT_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
M3K19_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
NEK10_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
PXK_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
KKCC2_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
GRK5_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
NRBP2_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
CIP4_HUMANGTR4_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030036actin cytoskeleton organizationNASbiological_process
GO:0008289lipid bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0006897endocytosisIEAbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0005737cytoplasmNAScellular_component
GO:0042995cell projectionIEAcellular_component
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0005856cytoskeletonIEAcellular_component
GO:0005938cell cortexIEAcellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0005794Golgi apparatusIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0001891phagocytic cupIEAcellular_component
GO:0007154cell communicationNASbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0005764lysosomeIEAcellular_component